Now showing items 1-3 of 3

    • Cholinergic Deficiency Hypothesis in Delirium: A Synthesis of Current Evidence 

      Hshieh, Tammy Ting; Fong, Tamara G; Marcantonio, Edward Ralph; Inouye, Sharon (Oxford University Press (OUP), 2008)
      Deficits in cholinergic function have been postulated to cause delirium and cognitive decline. This review examines current understanding of the cholinergic deficiency hypothesis in delirium by synthesizing evidence on ...
    • Cognitive and Brain Reserve and the Risk of Postoperative Delirium in Older Patients: Analysis of Data From a Prospective Observational Study 

      Saczynski, Jane; Inouye, Sharon; Kosar, Cyrus; Tommet, Doug; Marcantonio, Edward; Fong, Tamara; Hshieh, Tammy; Vasunilashorn, Sarinnapha; Metzger, Eran; Schmitt, Eva; Alsop, David; Jones, Richard N (Elsevier BV, 2014-11-01)
      Background Cognitive and brain reserve theories suggest that aspects of neural architecture or cognitive processes modify the impact of neuropathological processes on cognitive outcomes. While frequently studied in the ...
    • Head Circumference as a Useful Surrogate for Intracranial Volume in Older Adults 

      Hshieh, Tammy; Fox, Meaghan L.; Kosar, Cyrus M.; Cavallari, Michele; Guttmann, Charles; Alsop, David; Marcantonio, Edward; Schmitt, Eva M.; Jones, Richard N.; Inouye, Sharon (Cambridge University Press (CUP), 2016-01)
      Background Intracranial volume (ICV) has been proposed as a measure of maximum lifetime brain size. Accurate ICV measures require neuroimaging which is not always feasible for epidemiologic investigations. We examined ...