Browsing by Author "Blumberg, Richard"

Now showing items 1-15 of 15

    • CEACAM1 dampens antitumor immunity by down-regulating NKG2D ligand expression on tumor cells 

      Chen, Zhangguo; Chen, Lanfen; Olszak, Torsten; Zeissig, Sebastian; Kuo, Timothy T.; Mandelboim, Ofer; Beauchemin, Nicole; Lanier, Lewis L.; Baker, Kristi Dorothy; Huang, Yu-Hwa; Blumberg, Richard Steven (The Rockefeller University Press, 2011)
      Although carcinoembryonic antigen (CEA)–related cell adhesion molecule 1 (CEACAM1) has been viewed as a tumor suppressor, increasing clinical evidence shows that high levels of CEACAM1 expression on tumors correlates ...

    • Dendritic cell-bound IgE functions to restrain allergic inflammation at mucosal sites 

      Platzer, Barbara; Baker, Kristi; Vera, Miguel Pinilla; Singer, Kathleen; Panduro, Marisella; Lexmond, Willem S.; Turner, Devin; Vargas, Sara O.; Kinet, Jean-Pierre; Maurer, Dieter; Baron, Rebecca M.; Blumberg, Richard S.; Fiebiger, Edda (2014)
      Antigen-mediated crosslinking of Immunoglobulin E (IgE) bound to mast cells/basophils via FcεRI, the high affinity IgE Fc-receptor, is a well-known trigger of allergy. In humans, but not mice, dendritic cells (DCs) also ...

    • Eosinophilic esophagitis: published evidences for disease subtypes, indications for patient subpopulations, and how to translate patient observations to murine experimental models 

      Mudde, Anne C. A.; Lexmond, Willem S.; Blumberg, Richard S.; Nurko, Samuel; Fiebiger, Edda (BioMed Central, 2016)
      Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder of the esophagus and commonly classified as a Th2-type allergy. Major advances in our understanding of the EoE pathophysiology have recently been made, but ...

    • ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells 

      Niederreiter, Lukas; Fritz, Teresa M.J.; Adolph, Timon E.; Krismer, Anna-Maria; Offner, Felix A.; Tschurtschenthaler, Markus; Flak, Magdalena B.; Hosomi, Shuhei; Tomczak, Michal F.; Kaneider, Nicole C.; Sarcevic, Edina; Kempster, Sarah L.; Raine, Tim; Esser, Daniela; Rosenstiel, Philip; Kohno, Kenji; Iwawaki, Takao; Tilg, Herbert; Blumberg, Richard S.; Kaser, Arthur (The Rockefeller University Press, 2013)
      Unresolved endoplasmic reticulum (ER) stress in the epithelium can provoke intestinal inflammation. Hypomorphic variants of ER stress response mediators, such as X-box–binding protein 1 (XBP1), confer genetic risk for ...

    • Inducible colitis-associated glycome capable of stimulating the proliferation of memory CD4+ T cells 

      Nishida, Atsushi; Nagahama, Kiyotaka; Imaeda, Hirotsugu; Ogawa, Atsuhiro; Lau, Cindy W.; Kobayashi, Taku; Hisamatsu, Tadakazu; Preffer, Frederic I.; Mizoguchi, Emiko; Ikeuchi, Hiroki; Hibi, Toshifumi; Fukuda, Minoru; Andoh, Akira; Blumberg, Richard S.; Mizoguchi, Atsushi (The Rockefeller University Press, 2012)
      Immune responses are modified by a diverse and abundant repertoire of carbohydrate structures on the cell surface, which is known as the glycome. In this study, we propose that a unique glycome that can be identified through ...

    • Neonatal Fc Receptor Expression in Dendritic Cells Mediates Protective Immunity against Colorectal Cancer 

      Baker, Kristi; Rath, Timo; Flak, Magdalena Barbara; Arthur, Janelle C.; Chen, Zhangguo; Glickman, Jonathan Neil; Zlobec, Inti; Karamitopoulou, Eva; Stachler, Matthew Daniel; Odze, Robert D.; Lencer, Wayne Isaac; Jobin, Christian; Blumberg, Richard Steven (Elsevier BV, 2013)
      Cancers arising in mucosal tissues account for a disproportionately large fraction of malignancies. Immunoglobulin G (IgG) and the neonatal Fc receptor for IgG (FcRn) have an important function in the mucosal immune system ...

    • Neonatal Fc Receptor: From Immunity to Therapeutics 

      Kuo, Timothy Ting-Chang; Baker, Kristi Dorothy; Yoshida, Masaru; Qiao, Shuo-Wang; Aveson, Victoria G.; Lencer, Wayne Isaac; Blumberg, Richard Steven (Springer US, 2010)
      The neonatal Fc receptor (FcRn), also known as the Brambell receptor and encoded by Fcgrt, is a MHC class I like molecule that functions to protect IgG and albumin from catabolism, mediates transport of IgG across epithelial ...

    • Neonatal Fc receptors for IgG drive CD8+ T cell-mediated anti-cancer immunosurveillance at tolerogenic mucosal sites 

      Baker, Kristi; Rath, Timo; Pyzik, Michal; Blumberg, Richard S (Landes Bioscience, 2014)
      Mucosal boundaries, which are immunologically tolerogenic, and is further enhanced by undergo malignant transformation at high rates. We have identified the expression of neonatal Fc receptor for IgG (FcRn) by dendritic ...

    • Paneth cells as a site of origin for intestinal inflammation 

      Adolph, Timon E.; Tomczak, Michal F.; Niederreiter, Lukas; Ko, Hyun-Jeong; Böck, Janne; Martinez-Naves, Eduardo; Glickman, Jonathan N.; Tschurtschenthaler, Markus; Hartwig, John; Hosomi, Shuhei; Flak, Magdalena B.; Cusick, Jennifer L.; Kohno, Kenji; Iwawaki, Takao; Billmann-Born, Susanne; Raine, Tim; Bharti, Richta; Lucius, Ralph; Kweon, Mi-Na; Marciniak, Stefan J.; Choi, Augustine; Hagen, Susan J.; Schreiber, Stefan; Rosenstiel, Philip; Kaser, Arthur; Blumberg, Richard S. (2013)
      Autophagy related 16-like 1 (ATG16L1) as a genetic risk factor has exposed the critical role of autophagy in Crohn’s disease (CD)1. Homozygosity for the highly prevalent ATG16L1 risk allele, or murine hypomorphic (HM) ...

    • Recombinant factor VIII Fc (rFVIIIFc) fusion protein reduces immunogenicity and induces tolerance in hemophilia A mice 

      Krishnamoorthy, Sriram; Liu, Tongyao; Drager, Douglas; Patarroyo-White, Susannah; Chhabra, Ekta Seth; Peters, Robert; Josephson, Neil; Lillicrap, David; Blumberg, Richard S.; Pierce, Glenn F.; Jiang, Haiyan (2016)
      Anti-factor VIII (FVIII) antibodies is a major complication of FVIII replacement therapy for hemophilia A. We investigated the immune response to recombinant human factor VIII Fc (rFVIIIFc) in comparison to BDD-rFVIII and ...

    • The Recycling and Transcytotic Pathways for IgG Transport by FcRn are Distinct and Display an Inherent Polarity 

      Tzaban, Salit; Massol, Ramiro; Yen, Elizabeth Hechavarria; Hamman, Wendy; Frank, Scott Randy; Lapierre, Lynne A.; Hansen, Steen Henning; Goldenring, James R.; Blumberg, Richard Steven; Lencer, Wayne Isaac (Rockefeller University Press, 2009)
      The Fc receptor FcRn traffics immunoglobulin G (IgG) in both directions across polarized epithelial cells that line mucosal surfaces, contributing to host defense. We show that FcRn traffics IgG from either apical or ...

    • Regulation of Immune Responses by the Neonatal Fc Receptor and Its Therapeutic Implications 

      Rath, Timo; Baker, Kristi; Pyzik, Michal; Blumberg, Richard S. (Frontiers Media S.A., 2015)
      As a single receptor, the neonatal Fc receptor (FcRn) is critically involved in regulating albumin and IgG serum concentrations by protecting these two ligands from degradation. In addition to these essential homeostatic ...

    • The Role of FcRn in Antigen Presentation 

      Baker, Kristi; Rath, Timo; Pyzik, Michal; Blumberg, Richard S. (Frontiers Media S.A., 2014)
      Immunoglobulins are unique molecules capable of simultaneously recognizing a diverse array of antigens and themselves being recognized by a broad array of receptors. The abundance specifically of the IgG subclass and the ...

    • Serological Markers for Inflammatory Bowel Disease in AIDS Patients with Evidence of Microbial Translocation 

      Kamat, Anupa U; Ancuta, Petronela; Blumberg, Richard Steven; Gabuzda, Dana Helga (Public Library of Science, 2010)
      Background: Breakdown of the gut mucosal barrier during chronic HIV infection allows translocation of bacterial products such as lipopolysaccharides (LPS) from the gut into the circulation. Microbial translocation also ...

    • Transepithelial Transport of Fc-Targeted Nanoparticles by the Neonatal Fc Receptor for Oral Delivery 

      Pridgen, E. M.; Alexis, F.; Kuo, T; Levy-Nissenbaum, E.; Karnik, R.; Blumberg, Richard Steven; Langer, Robert S.; Farokhzad, Omid Cameron (American Association for the Advancement of Science (AAAS), 2013)
      Nanoparticles are poised to have a tremendous impact on the treatment of many diseases, but their broad application is limited because currently they can only be administered by parenteral methods. Oral administration of ...