Browsing by Author "Levy, Jonathan"
Now showing items 1-18 of 18
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The Air Quality Impacts of Road Closures Associated with the 2004 Democratic National Convention in Boston
Levy, Jonathan Ian; Baxter, Lisa K; Clougherty, Jane E (BioMed Central, 2006)Background: The Democratic National Convention (DNC) in Boston, Massachusetts in 2004 provided an opportunity to evaluate the impacts of a localized and short-term but potentially significant change in traffic patterns on ... -
Between-Airport Heterogeneity in Air Toxics Emissions Associated with Individual Cancer Risk Thresholds and Population Risks
Zhou, Ying; Levy, Jonathan Ian (BioMed Central, 2009)Background: Airports represent a complex source type of increasing importance contributing to air toxics risks. Comprehensive atmospheric dispersion models are beyond the scope of many applications, so it would be valuable ... -
Continuous Evolution of Base Editors With Expanded Target Compatibility and Improved Activity
Zheng, Christine; Wilson, Christopher; Thuronyi, Benjamin; Koblan, Luke; Levy, Jonathan; Yeh, Wei-Hsi; Newby, Gregory; Bhaumik, Mantu; Shubina-Oleinik, Olga; Holt, Jeffrey; Liu, David (Springer Science and Business Media LLC, 2019-07-22)Base editors use DNA-modifying enzymes targeted with a catalytically impaired CRISPR protein to precisely install point mutations. Here, we develop phage-assisted continuous evolution of base editors (BE–PACE) to improve ... -
Does Living Near a Superfund Site Contribute to Higher Polychlorinated Biphenyl (PCB) Exposure?
Tolbert, Paige E.; Choi, Anna L; Choi, Anna Lai; Levy, Jonathan Ian; Dockery, Douglas W.; Ryan, Louise Marie; Altshul, Larisa; Korrick, Susan Abigail (National Institute of Environmental Health Sciences, 2006)We assessed determinants of cord serum polychlorinated biphenyl (PCB) levels among 720 infants born between 1993 and 1998 to mothers living near a PCB-contaminated Superfund site in Massachusetts, measuring the sum of 51 ... -
The Effects of Indoor Environmental Exposures on Pediatric Asthma: A Discrete Event Simulation Model
Fabian, Maria Patricia; Stout, Natasha K; Adamkiewicz, Gary; Geggel, Amelia; Ren, Cizao; Sandel, Megan; Levy, Jonathan Ian (BioMed Central, 2012)Background: In the United States, asthma is the most common chronic disease of childhood across all socioeconomic classes and is the most frequent cause of hospitalization among children. Asthma exacerbations have been ... -
Evaluation of the Public Health Impacts of Traffic Congestion: A Health Risk Assessment
Levy, Jonathan Ian; Buonocore, Jonathan James; von Stackelberg, Katherine Ellen (BioMed Central, 2010)Background: Traffic congestion is a significant issue in urban areas in the United States and around the world. Previous analyses have estimated the economic costs of congestion, related to fuel and time wasted, but few ... -
Factors Influencing the Spatial Extent of Mobile Source Air Pollution Impacts: A Meta-Analysis
Zhou, Ying; Levy, Jonathan Ian (BioMed Central, 2007)Background: There has been growing interest among exposure assessors, epidemiologists, and policymakers in the concept of "hot spots", or more broadly, the "spatial extent" of impacts from traffic-related air pollutants. ... -
A Health Impact Assessment of Proposed Public Transit Service Cuts and Fare Increases in Boston, Massachusetts
James, Peter; Ito, Katherine; Buonocore, Jonathan James; Levy, Jonathan Ian; Arcaya, Mariana C (MDPI, 2014-06-13)Transportation decisions have health consequences that are often not incorporated into policy-making processes. Health Impact Assessment (HIA) is a process that can be used to evaluate health effects of transportation ... -
Health, Wealth, and Air Pollution: Advancing Theory and Methods
O'Neill, Marie S; Jerrett, Michael; Cohen, Aaron J; Gouveia, Nelson; Wilkinson, Paul; Fletcher, Tony; Cifuentes, Luis; Kawachi, Ichiro; Levy, Jonathan Ian; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2003)The effects of both ambient air pollution and socioeconomic position (SEP) on health are well documented. A limited number of recent studies suggest that SEP may itself play a role in the epidemiology of disease and death ... -
Incorporating Concepts of Inequality and Inequity into Health Benefits Analysis
Levy, Jonathan Ian; Chemerynski, Susan M; Tuchmann, Jessica L (BioMed Central, 2006)Background: Although environmental policy decisions are often based in part on both risk assessment information and environmental justice concerns, formalized approaches for addressing inequality or inequity when estimating ... -
Land use regression modeling of intra-urban residential variability in multiple traffic-related air pollutants
Clougherty, Jane E; Wright, Rosalind Jo; Baxter, Lisa K; Levy, Jonathan Ian (BioMed Central, 2008)Background: There is a growing body of literature linking GIS-based measures of traffic density to asthma and other respiratory outcomes. However, no consensus exists on which traffic indicators best capture variability ... -
Lung Function, Asthma Symptoms, and Quality of Life for Children in Public Housing in Boston: A Case-Series Analysis
Levy, Jonathan Ian; Welker-Hood, LK; Clougherty, Jane E; Dodson, Robin Elizabeth; Steinbach, Suzanne; Hynes, HP (BioMed Central, 2004)Background: Children in urban public housing are at high risk for asthma, given elevated environmental and social exposures and suboptimal medical care. For a multifactorial disease like asthma, design of intervention ... -
Modeling Environmental Tobacco Smoke (ETS) Infiltration in Low-Income Multifamily Housing before and after Building Energy Retrofits
Fabian, Maria Patricia; Lee, Sharon Kitman; Underhill, Lindsay Jean; Vermeer, Kimberly; Adamkiewicz, Gary; Levy, Jonathan Ian (MDPI, 2016)Secondhand exposure to environmental tobacco smoke (ETS) in multifamily housing remains a health concern despite strong recommendations to implement non-smoking policies. Multiple studies have documented exposure to ETS ... -
Modeling Joint Exposures and Health Outcomes for Cumulative Risk Assessment: The Case of Radon and Smoking
Chahine, Teresa; Schultz, Bradley D.; Zartarian, Valerie G.; Xue, Jianping; Subramanian, S.V. Venkata; Levy, Jonathan Ian (MDPI AG, 2011)Community-based cumulative risk assessment requires characterization of exposures to multiple chemical and non-chemical stressors, with consideration of how the non-chemical stressors may influence risks from chemical ... -
Modeling Spatial Patterns of Traffic-Related Air Pollutants in Complex Urban Terrain
Zwack, Leonard M.; Paciorek, Christopher Joseph; Spengler, John D.; Levy, Jonathan Ian (National Institute of Environmental Health Sciences, 2011)Background: The relationship between traffic emissions and mobile-source air pollutant concentrations is highly variable over space and time and therefore difficult to model accurately, especially in urban settings with ... -
Risk-based Prioritization among Air Pollution Control Strategies in the Yangtze River Delta, China
Zhou, Ying; Fu, Joshua S.; Zhuang, Guoshun; Levy, Jonathan Ian (National Institute of Environmental Health Sciences, 2010)Background: The Yangtze River Delta (YRD) in China is a densely populated region with recent dramatic increases in energy consumption and atmospheric emissions. Objectives: We studied how different emission sectors influence ... -
Synergistic effects of traffic-related air pollution and exposure to violence on urban asthma etiology
Clougherty, Jane E.; Levy, Jonathan Ian; Kubzansky, Laura Diane; Ryan, P. Barry; Suglia, Shakira Franco; Canner, Marina Jacobson; Wright, Rosalind Jo (National Institute of Environmental Health Sciences, 2007)Background: Disproportionate life stress and consequent physiologic alteration (i.e., immune dysregulation) has been proposed as a major pathway linking socioeconomic position, environmental exposures, and health disparities. ... -
Using Physiologically-Based Pharmacokinetic Models to Incorporate Chemical and Non-Chemical Stressors into Cumulative Risk Assessment: A Case Study of Pesticide Exposures
Wason, Susan Chemerynski; Smith, Thomas J.; Perry, Melissa J.; Levy, Jonathan Ian (MDPI, 2012)Cumulative risk assessment has been proposed as an approach to evaluate the health risks associated with simultaneous exposure to multiple chemical and non-chemical stressors. Physiologically based pharmacokinetic/pharmacodynamic ...