Browsing by Author "Coen, Donald"
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Binding Parameters and Thermodynamics of the Interaction of the Human Cytomegalovirus DNA Polymerase Accessory Protein, UL44, with DNA: Implications for the Processivity Mechanism
Loregian, Arianna; Sinigalia, Elisa; Mercorelli, Beatrice; Palù, Giorgio; Coen, Donald Mark (Oxford University Press, 2007)The mechanisms of processivity factors of herpesvirus DNA polymerases remain poorly understood. The proposed processivity factor for human cytomegalovirus DNA polymerase is a DNA-binding protein, UL44. Previous findings, ... -
A Herpesviral Lytic Protein Regulates the Structure of Latent Viral Chromatin
Raja, Priya; Lee, Jennifer S.; Pan, Dongli; Pesola, Jean M.; Coen, Donald M.; Knipe, David M. (American Society for Microbiology, 2016)ABSTRACT Latent infections by viruses usually involve minimizing viral protein expression so that the host immune system cannot recognize the infected cell through the viral peptides presented on its cell surface. Herpes ... -
HIV Integrase Inhibitors Block Replication of Alpha-, Beta-, and Gammaherpesviruses
Yan, Zhipeng; Bryant, Kevin F.; Gregory, Sean M.; Angelova, Magdalena; Dreyfus, David H.; Zhao, Xue Zhi; Coen, Donald M.; Burke, Terrence R.; Knipe, David M. (American Society of Microbiology, 2014)ABSTRACT The catalytic site of the HIV integrase is contained within an RNase H-like fold, and numerous drugs have been developed that bind to this site and inhibit its activity. Herpes simplex virus (HSV) encodes two ... -
Importance of the Pre-\(NH_2\)-Terminal Domain of HSV-1 DNA Polymerase for Viral Replication
Terrell, Shariya Louise (2013-03-15)The catalytic subunit of the herpes simplex virus 1 DNA polymerase (HSV-1 Pol) has been extensively studied; however, its full complement of functional domains has yet to be characterized. The previously uncharacterized ... -
Kinetics of Facultative Heterochromatin and Polycomb Group Protein Association with the Herpes Simplex Viral Genome during Establishment of Latent Infection
Cliffe, Anna R.; Coen, Donald Mark; Knipe, David Mahan (American Society of Microbiology, 2013)ABSTRACT The herpes simplex virus (HSV) genome is associated with heterochromatic histone modifications, including trimethylation of the lysine 27 residue of histone H3 (H3K27me3), during latent infection of neurons. Here ... -
Persistent Expression of Chemokine and Chemokine Receptor RNAs at Primary and Latent Sites of Herpes Simplex Virus 1 Infection
Cook, W. James; Kramer, Martha Frances; Walker, Russell M; Burwell, Timothy J; Holman, Holly A; Coen, Donald Mark; Knipe, David Mahan (BioMed Central, 2004)Inflammatory cytokines and infiltrating T cells are readily detected in herpes simplex virus (HSV) infected mouse cornea and trigeminal ganglia (TG) during the acute phase of infection, and certain cytokines continue to ... -
A Role for Nuclear F-Actin Induction in Human Cytomegalovirus Nuclear Egress
Wilkie, Adrian R.; Lawler, Jessica L.; Coen, Donald M. (American Society for Microbiology, 2016)ABSTRACT Herpesviruses, which include important pathogens, remodel the host cell nucleus to facilitate infection. This remodeling includes the formation of structures called replication compartments (RCs) in which herpesviruses ... -
Viral Mimicry of Cdc2/cyclin-dependent Kinase 1 Mediates Disruption of Nuclear Lamina during Human Cytomegalovirus Nuclear Egress
Hamirally, Sofia; Kamil, Jeremy P.; Ndassa-Colday, Yasmine M.; Lin, Alison J.; Jahng, Wan Jin; Baek, Moon-Chang; Noton, Sarah; Silva, Laurie A.; Simpson-Holley, Martha; Knipe, David Mahan; Golan, David Eric; Marto, Jarrod; Coen, Donald Mark (Public Library of Science, 2009)The nuclear lamina is a major obstacle encountered by herpesvirus nucleocapsids in their passage from the nucleus to the cytoplasm (nuclear egress). We found that the human cytomegalovirus (HCMV)-encoded protein kinase ...