Browsing by Author "Kostic, Aleksandar"

Now showing items 1-5 of 5

    • Deep Sequencing and Functional Analyses Identify a Role of Fusobacterium Species in Colorectal Tumorigenesis 

      Kostic, Aleksandar David (2013-09-30)
      The tumor microenvironment is a complex community consisting of neoplastic cells, surrounding stromal cells, a broad array of immune cells, and a microbiota. By sheer numbers, the microbiota has its greatest manifestation ...

    • Dysbiosis, inflammation, and response to treatment: a longitudinal study of pediatric subjects with newly diagnosed inflammatory bowel disease 

      Shaw, Kelly A.; Bertha, Madeline; Hofmekler, Tatyana; Chopra, Pankaj; Vatanen, Tommi; Srivatsa, Abhiram; Prince, Jarod; Kumar, Archana; Sauer, Cary; Zwick, Michael E.; Satten, Glen A.; Kostic, Aleksandar D.; Mulle, Jennifer G.; Xavier, Ramnik J.; Kugathasan, Subra (BioMed Central, 2016)
      Background: Gut microbiome dysbiosis has been demonstrated in subjects with newly diagnosed and chronic inflammatory bowel disease (IBD). In this study we sought to explore longitudinal changes in dysbiosis and ascertain ...

    • Exploring host-microbiota interactions in animal models and humans 

      Kostic, Aleksandar David; Howitt, Michael; Garrett, Wendy S. (Cold Spring Harbor Laboratory Press, 2013)
      The animal and bacterial kingdoms have coevolved and coadapted in response to environmental selective pressures over hundreds of millions of years. The meta'omics revolution in both sequencing and its analytic pipelines ...

    • Genomic analysis identifies association of Fusobacterium with colorectal carcinoma 

      Kostic, Aleksandar David; Gevers, D.; Pedamallu, Chandra Sekhar; Michaud, Monia; Duke, F.; Earl, A. M.; Ojesina, Akinyemi Ifedapo; Jung, J.; Bass, Adam Joel; Tabernero, J.; Baselga, J.; Liu, C.; Shivdasani, Ramesh Arjun; Ogino, Shuji; Birren, B. W.; Huttenhower, Curtis; Garrett, Wendy S.; Meyerson, Matthew Langer (Cold Spring Harbor Laboratory Press, 2011)
      The tumor microenvironment of colorectal carcinoma is a complex community of genomically altered cancer cells, nonneoplastic cells, and a diverse collection of microorganisms. Each of these components may contribute to ...

    • Human Genome-Wide RNAi Screen Identifies an Essential Role for Inositol Pyrophosphates in Type-I Interferon Response 

      Pulloor, Niyas Kudukkil; Nair, Sajith; Kostic, Aleksandar D.; Bist, Pradeep; Weaver, Jeremy D.; Riley, Andrew M.; Tyagi, Richa; Uchil, Pradeep D.; York, John D.; Snyder, Solomon H.; García-Sastre, Adolfo; Potter, Barry V. L.; Lin, Rongtuan; Shears, Stephen B.; Xavier, Ramnik J.; Krishnan, Manoj N. (Public Library of Science, 2014)
      The pattern recognition receptor RIG-I is critical for Type-I interferon production. However, the global regulation of RIG-I signaling is only partially understood. Using a human genome-wide RNAi-screen, we identified 226 ...