Browsing by Author "Stiles, Charles"

Now showing items 1-4 of 4

    • A Genome-Wide In Situ Hybridization Map of RNA-Binding Proteins reveals Anatomically Restricted Expression in the Developing Mouse Brain 

      McKee, Adrienne E.; Minet, Emmanuel; Stern, Charlene; Riahi, Shervin; Stiles, Charles Dean; Silver, Pamela A. (BioMed Central, 2005)
      Background: In eukaryotic cells, RNA-binding proteins (RBPs) contribute to gene expression by regulating the form, abundance, and stability of both coding and non-coding RNA. In the vertebrate brain, RBPs account for many ...

    • Identification of Molecular Compartments and Genetic Circuitry in the Developing Mammalian Kidney 

      Duah, Mary; Staser, Karl; Valerius, Michael Todd; Hansard, Jennifer K.; Guo, Jin-jin; McMahon, Jill Ann; Vaughan, Joseph E.; Faria, Diane; Georgas, Kylie; Rumballe, Bree; Ren, Qun; Krautzberger, A. Michaela; Junker, Jan P.; Thiagarajan, Rathi D.; Machanick, Philip; Gray, Paul A.; van Oudenaarden, Alexander; Rowitch, David H.; Stiles, Charles Dean; Ma, Qiufu; Grimmond, Sean M.; Bailey, Timothy L.; Little, Melissa H.; McMahon, Andrew P.; Yu, Jing (Company of Biologists, 2012)
      Lengthy developmental programs generate cell diversity within an organotypic framework, enabling the later physiological actions of each organ system. Cell identity, cell diversity and cell function are determined by cell ...

    • Molecular imaging of drug transit through the blood-brain barrier with MALDI mass spectrometry imaging 

      Liu, Xiaohui; Ide, Jennifer L.; Norton, Isaiah; Marchionni, Mark A.; Ebling, Maritza C.; Wang, Lan Y.; Davis, Erin; Sauvageot, Claire M.; Kesari, Santosh; Kellersberger, Katherine A.; Easterling, Michael L.; Santagata, Sandro; Stuart, Darrin D.; Alberta, John; Agar, Jeffrey N.; Stiles, Charles D.; Agar, Nathalie Y. R. (Nature Publishing Group, 2013)
      Drug transit through the blood-brain barrier (BBB) is essential for therapeutic responses in malignant glioma. Conventional methods for assessment of BBB penetrance require synthesis of isotopically labeled drug derivatives. ...

    • Profiling Critical Cancer Gene Mutations in Clinical Tumor Samples 

      Campbell, Catarina D.; Kehoe, Sarah M.; Hatton, Charles; Niu, Lili; Yao, Keluo; Hanna, Megan; Mondal, Chandrani; Luongo, Lauren; Baker, Alissa C.; Philips, Juliet; Goff, Deborah J.; Rubin, Mark A.; Corso, Gianni; Roviello, Franco; MacConaill, Laura Eleanor; Bass, Adam Joel; Davis, Matthew J; Emery, Caroline Margaret; Fiorentino, Michelangelo; Polyak, Kornelia; Chan, Jennifer Ang; Wang, Yufang; Fletcher, Jonathan A.; Santagata, Sandro; Shivdasani, Ramesh Arjun; Kieran, Mark W.; Ligon, Keith Lloyd; Stiles, Charles Dean; Hahn, William C.; Meyerson, Matthew Langer; Garraway, Levi Alexander; Jones, Chris (Public Library of Science, 2009)
      Background: Detection of critical cancer gene mutations in clinical tumor specimens may predict patient outcomes and inform treatment options; however, high-throughput mutation profiling remains underdeveloped as a diagnostic ...