Now showing items 1-3 of 3

    • Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant 

      Kamberov, Yana George; Wang, Sijia; Tan, Jingze; Gerbault, Pascale; Wark, Abigail; Tan, Longzhi; Yang, Yajun; Li, Shilin; Tang, Kun; Chen, Hua; Powell, Adam; Itan, Yuval; Fuller, Dorian; Lohmueller, Jason; Mao, Junhao; Schachar, Asa; Paymer, Madeline; Hostetter, Elizabeth; Byrne, Elizabeth; Burnett, Melissa; McMahon, Andrew P.; Thomas, Mark G.; Lieberman, Daniel E.; Jin, Li; Tabin, Clifford James; Morgan, Bruce Allan; Sabeti, Pardis Christine (Elsevier BV, 2013)
      An adaptive variant of the human Ectodysplasin receptor, EDARV370A, is one of the strongest candidates of recent positive selection from genome-wide scans. We have modeled EDAR370A in mice and characterized its phenotype ...
    • Olfactory sensory neurons transiently express multiple olfactory receptors during development 

      Tan, Longzhi; Li, Qian; Xie, X Sunney (John Wiley and Sons Inc., 2015)
      Abstract In mammals, each olfactory sensory neuron randomly expresses one, and only one, olfactory receptor (OR)—a phenomenon called the “one‐neuron‐one‐receptor” rule. Although extensively studied, this rule was never ...
    • Rare event of histone demethylation can initiate singular gene expression of olfactory receptors 

      Tan, Longzhi; Zong, Chenghang; Xie, Xiaoliang Sunney (Proceedings of the National Academy of Sciences, 2013)
      In mammals, the sense of odors relies on the peculiar expression pattern of olfactory receptors (ORs). Each single neuron chooses one, and only one, from all ∼1,400 OR genes that are present in a mouse genome. In neurobiology, ...