Browsing by Author "Hallett, Penelope"
Now showing items 1-3 of 3
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Implanted Reuptake-deficient or Wild-type Dopaminergic Neurons Improve ON L-dopa Dyskinesias Without OFF-dyskinesias in a Rat Model of Parkinson's Disease
Vinuela, Angel; Hallett, Penelope Jane; Reske-Nielsen, C.; Patterson, M.; Sotnikova, T. D.; Caron, M. G.; Gainetdinov, R. R.; Isacson, Ole Stefan (Oxford University Press, 2008)OFF-L-dopa dyskinesias have been a surprising side-effect of intrastriatal foetal ventral mesencephalic transplantation in patients with Parkinson's disease. It has been proposed that excessive and unregulated dopaminergic ... -
A Nurr1 Agonist Causes Neuroprotection in a Parkinson’s Disease Lesion Model Primed with the Toll-Like Receptor 3 dsRNA Inflammatory Stimulant Poly(I:C)
Smith, Gaynor A.; Rocha, Emily M.; Rooney, Thomas; Barneoud, Pascal; McLean, Jesse R.; Beagan, Jonathan; Osborn, Teresia; Coimbra, Madeleine; Luo, Yongyi; Hallett, Penelope J.; Isacson, Ole (Public Library of Science, 2015)Dopaminergic neurons in the substantia nigra pars compacta (SNpc) are characterized by the expression of genes required for dopamine synthesis, handling and reuptake and the expression of these genes is largely controlled ... -
Progressive decline of glucocerebrosidase in aging and Parkinson's disease
Rocha, Emily M; Smith, Gaynor A; Park, Eric; Cao, Hongmei; Brown, Eilish; Hallett, Penelope; Isacson, Ole (BlackWell Publishing Ltd, 2015)The principal risk factor for developing most adult onset neurodegenerative diseases is aging, with incidence rising significantly after age 50. Despite research efforts, the causes of Parkinson's disease (PD) remain ...