Now showing items 1-9 of 9

    • Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma 

      Shao, Huilin; Chung, Jaehoon; Lee, Kyungheon; Balaj, Leonora; Min, Changwook; Carter, Bob S.; Hochberg, Fred H.; Breakefield, Xandra O.; Lee, Hakho; Weissleder, Ralph (Nature Pub. Group, 2015)
      Real-time monitoring of drug efficacy in glioblastoma multiforme (GBM) is a major clinical problem as serial re-biopsy of primary tumours is often not a clinical option. MGMT (O6-methylguanine DNA methyltransferase) and ...
    • Highly sensitive detection of protein biomarkers via nuclear magnetic resonance biosensor with magnetically engineered nanoferrite particles 

      Jeun, Minhong; Park, Sungwook; Lee, Hakho; Lee, Kwan Hyi (Dove Medical Press, 2016)
      Magnetic-based biosensors are attractive for on-site detection of biomarkers due to the low magnetic susceptibility of biological samples. Here, we report a highly sensitive magnetic-based biosensing system that is composed ...
    • Holographic Assessment of Lymphoma Tissue (HALT) for Global Oncology Field Applications 

      Pathania, Divya; Im, Hyungsoon; Kilcoyne, Aoife; Sohani, Aliyah R.; Fexon, Lioubov; Pivovarov, Misha; Abramson, Jeremy S.; Randall, Thomas C.; Chabner, Bruce A.; Weissleder, Ralph; Lee, Hakho; Castro, Cesar M. (Ivyspring International Publisher, 2016)
      Low-cost, rapid and accurate detection technologies are key requisites to cope with the growing global cancer challenges. The need is particularly pronounced in resource-limited settings where treatment opportunities are ...
    • Magnetic Nanoparticles and MicroNMR for Diagnostic Applications 

      Shao, Huilin; Min, Changwook; Issadore, David Aaron; Liong, Monty; Yoon, Tae-Jong; Weissleder, Ralph; Lee, Hakho (Ivyspring International Publisher, 2012)
      Sensitive and quantitative measurements of clinically relevant protein biomarkers, pathogens and cells in biological samples would be invaluable for disease diagnosis, monitoring of malignancy, and for evaluating therapy ...
    • A magneto-DNA nanoparticle system for the rapid and sensitive diagnosis of enteric fever 

      Park, Ki Soo; Chung, Hyun Jung; Khanam, Farhana; Lee, Hakho; Rashu, Rasheduzzaman; Bhuiyan, Md. Taufiqur; Berger, Amanda; Harris, Jason B.; Calderwood, Stephen B.; Ryan, Edward T.; Qadri, Firdausi; Weissleder, Ralph; Charles, Richelle C. (Nature Publishing Group, 2016)
      There is currently no widely available optimal assay for diagnosing patients with enteric fever. Here we present a novel assay designed to detect amplified Salmonella nucleic acid (mRNA) using magneto-DNA probes and a ...
    • Monocyte Subset Dynamics in Human Atherosclerosis Can Be Profiled with Magnetic Nano-Sensors 

      Wildgruber, Moritz; Chudnovskiy, Aleksey; Yoon, Tae-Jong; Etzrodt, Martin; Lee, Hakho; Pittet, Mikael J.; Nahrendorf, Matthias; Croce, Kevin James; Libby, Peter; Weissleder, Ralph; Swirski, Filip K. (Public Library of Science, 2009)
      Monocytes are circulating macrophage and dendritic cell precursors that populate healthy and diseased tissue. In humans, monocytes consist of at least two subsets whose proportions in the blood fluctuate in response to ...
    • Nanoparticle Detection of Urinary Markers for Point-of-Care Diagnosis of Kidney Injury 

      Chung, Hyun Jung; Pellegrini, Kathryn L.; Chung, Jaehoon; Wanigasuriya, Kamani; Jayawardene, Innocent; Lee, Kyungheon; Lee, Hakho; Vaidya, Vishal S.; Weissleder, Ralph (Public Library of Science, 2015)
      The high incidence of acute and chronic kidney injury due to various environmental factors such as heavy metals or chemicals has been a major problem in developing countries. However, the diagnosis of kidney injury in these ...
    • On Chip Analysis of CNS Lymphoma in Cerebrospinal Fluid 

      Turetsky, Anna; Lee, Kyungheon; Song, Jun; Giedt, Randy J.; Kim, Eunha; Kovach, Alexandra E.; Hochberg, Ephraim P.; Castro, Cesar M.; Lee, Hakho; Weissleder, Ralph (Ivyspring International Publisher, 2015)
      Molecular profiling of central nervous system lymphomas in cerebrospinal fluid (CSF) samples can be challenging due to the paucicellular and limited nature of the samples. Presented herein is a microfluidic platform for ...
    • Sparsity-Based Pixel Super Resolution for Lens-Free Digital In-line Holography 

      Song, Jun; Leon Swisher, Christine; Im, Hyungsoon; Jeong, Sangmoo; Pathania, Divya; Iwamoto, Yoshiko; Pivovarov, Misha; Weissleder, Ralph; Lee, Hakho (Nature Publishing Group, 2016)
      Lens-free digital in-line holography (LDIH) is a promising technology for portable, wide field-of-view imaging. Its resolution, however, is limited by the inherent pixel size of an imaging device. Here we present a new ...