Browsing by Author "Jo, Hakryul"
Now showing items 1-7 of 7
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Cancer Cell-Derived Clusterin Modulates the Phosphatidylinositol 3'-Kinase-Akt Pathway through Attenuation of Insulin-Like Growth Factor 1 during Serum Deprivation
Jo, Hakryul; Jia, Yonghui; Subramanian, Kulandayan K.; Hattori, Hidenori; Luo, Hongbo (American Society for Microbiology, 2008)Cancer cells in their respective microenvironments must endure various growth-constraining stresses. Under these conditions, the cancer cell-derived factors are thought to modulate the signaling pathways between cell growth ... -
Deactivation of Akt by a Small Molecule Inhibitor Targeting Pleckstrin Homology Domain and Facilitating Akt Ubiquitination
Jo, Hakryul; Lo, Pang-Kuo; Li, Yitang; Loison, Fabien; Green, Sarah; Wang, Jake; Silberstein, Leslie E.; Ye, Keqiang; Chen, Hexin; Luo, Hongbo (Proceedings of the National Academy of Sciences, 2011)The phosphatidylinositol-3,4,5-triphosphate (PIP3) binding function of pleckstrin homology (PH) domain is essential for the activation of oncogenic Akt/PKB kinase. Following the PIP3-mediated activation at the membrane, ... -
Exploiting Effectors of Rac GTPase
Jo, Hakryul; Luo, Hongbo (Elsevier BV, 2012) -
Microtubule Dynamics Regulates Akt Signaling via Dynactin p150
Jo, Hakryul; Loison, Fabien; Luo, Hongbo (Elsevier BV, 2014)Following activation at the plasma membrane, Akt is subsequently deactivated in the cytoplasm. Although activation and deactivation of Akt must sometimes be separated in order to elicit and control cellular responses, the ... -
Natural Product Celastrol Destabilizes Tubulin Heterodimer and Facilitates Mitotic Cell Death Triggered by Microtubule-Targeting Anti-Cancer Drugs
Jo, Hakryul; Loison, Fabien Xavier; Hattori, Hidenori; Silberstein, Leslie E.; Yu, Hongtao; Luo, Hongbo (Public Library of Science, 2010)Background: Microtubule drugs are effective anti-cancer agents, primarily due to their ability to induce mitotic arrest and subsequent cell death. However, some cancer cells are intrinsically resistant or acquire a resistance. ... -
Small Molecule-Induced Cytosolic Activation of Protein Kinase Akt Rescues Ischemia-Elicited Neuronal Death
Jo, Hakryul; Mondal, Subhanjan; Tan, Dewar J.; Nagata, Eiichiro; Takizawa, Shunya; Sharma, Alok Kumar; Hou, Qingming; Shanmugasundaram, Kumaran; Prasad, Amit; Tung, Joe K.; Tejeda, Alexander O.; Man, Hengye; Rigby, Alan C.; Luo, Hongbo (Proceedings of the National Academy of Sciences, 2012)Elevating Akt activation is an obvious clinical strategy to prevent progressive neuronal death in neurological diseases. However, this endeavor has been hindered because of the lack of specific Akt activators. Here, from ... -
Small-Molecule Screen Identifies Reactive Oxygen Species as Key Regulators of Neutrophil Chemotaxis
Hattori, Hidenori; Subramanian, Kulandayan K.; Sakai, Jiro; Jia, Yonghui; Li, Yitang; Porter, Timothy F.; Loison, Fabien; Sarraj, Bara; Kasorn, Anongnard; Jo, Hakryul; Blanchard, Catlyn; Zirkle, Dorothy; McDonald, Douglas Ray; Pai, Sung-Yun; Serhan, Charles Nicholas; Luo, Hongbo (Proceedings of the National Academy of Sciences, 2010)Neutrophil chemotaxis plays an essential role in innate immunity, but the underlying cellular mechanism is still not fully characterized. Here, using a small-molecule functional screening, we identified NADPH oxidase–dependent ...