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    • Large-scale identification of genetic design strategies using local search 

      Lun, Desmond S; Rockwell, Graham; Guido, Nicholas; Baym, Michael Hartmann; Kelner, Jonathan A; Berger, Bonnie; Galagan, James E; Church, George McDonald (Nature Publishing Group, 2009)
      In the past decade, computational methods have been shown to be well suited to unraveling the complex web of metabolic reactions in biological systems. Methods based on flux–balance analysis (FBA) and bi-level optimization ...