Now showing items 1-3 of 3

    • Amino Acid Changes in the HIV-1 gp41 Membrane Proximal Region Control Virus Neutralization Sensitivity 

      Bradley, Todd; Trama, Ashley; Tumba, Nancy; Gray, Elin; Lu, Xiaozhi; Madani, Navid; Jahanbakhsh, Fatemeh; Eaton, Amanda; Xia, Shi-Mao; Parks, Robert; Lloyd, Krissey E.; Sutherland, Laura L.; Scearce, Richard M.; Bowman, Cindy M.; Barnett, Susan; Abdool-Karim, Salim S.; Boyd, Scott D.; Melillo, Bruno; Smith, Amos B.; Sodroski, Joseph; Kepler, Thomas B.; Alam, S.Munir; Gao, Feng; Bonsignori, Mattia; Liao, Hua-Xin; Moody, M. Anthony; Montefiori, David; Santra, Sampa; Morris, Lynn; Haynes, Barton F. (Elsevier, 2016)
      Most HIV-1 vaccines elicit neutralizing antibodies that are active against highly sensitive (tier-1) viruses or rare cases of vaccine-matched neutralization-resistant (tier-2) viruses, but no vaccine has induced antibodies ...
    • Structure-Based Design, Synthesis and Validation of CD4-Mimetic Small Molecule Inhibitors of HIV-1 Entry: Conversion of a Viral Entry Agonist to an Antagonist 

      Courter, Joel R.; Madani, Navid; Sodroski, Joseph; Schön, Arne; Freire, Ernesto; Kwong, Peter D.; Hendrickson, Wayne A.; Chaiken, Irwin M.; LaLonde, Judith M.; Smith, Amos B. (American Chemical Society, 2014)
      Conspectus This Account provides an overview of a multidisciplinary consortium focused on structure-based strategies to devise small molecule antagonists of HIV-1 entry into human T-cells, which if successful would hold ...
    • Thermal Stability of the Human Immunodeficiency Virus Type 1 (HIV-1) Receptors, CD4 and CXCR4, Reconstituted in Proteoliposomes 

      Zhukovsky, Mikhail A.; Basmaciogullari, Stéphane; Schwartz, Olivier; Pacheco, Beatriz; Wang, Jiping; Madani, Navid; Haim, Hillel; Sodroski, Joseph Gerard (Public Library of Science, 2010)
      Background: The entry of human immunodeficiency virus (HIV-1) into host cells involves the interaction of the viral exterior envelope glycoprotein, gp120, and receptors on the target cell. The HIV-1 receptors are CD4 and ...