Now showing items 1-6 of 6

    • Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion 

      Bruinsma, Bote G.; Avruch, James H.; Weeder, Pepijn D.; Sridharan, Gautham V.; Uygun, Basak E.; Karimian, Negin G.; Porte, Robert J.; Markmann, James F.; Yeh, Heidi; Uygun, Korkut (MyJove Corporation, 2015)
      There is currently a severe shortage of liver grafts available for transplantation. Novel organ preservation techniques are needed to expand the pool of donor livers. Machine perfusion of donor liver grafts is an alternative ...
    • Metabolic profiling during ex vivo machine perfusion of the human liver 

      Bruinsma, Bote G.; Sridharan, Gautham V.; Weeder, Pepijn D.; Avruch, James H.; Saeidi, Nima; Özer, Sinan; Geerts, Sharon; Porte, Robert J.; Heger, Michal; van Gulik, Thomas M.; Martins, Paulo N.; Markmann, James F.; Yeh, Heidi; Uygun, Korkut (Nature Publishing Group, 2016)
      As donor organ shortages persist, functional machine perfusion is under investigation to improve preservation of the donor liver. The transplantation of donation after circulatory death (DCD) livers is limited by poor ...
    • Successful Supercooled Liver Storage for 4 Days 

      Berendsen, Tim A.; Bruinsma, Bote G.; Puts, Catheleyne F.; Saeidi, Nima; Usta, O. Berk; Uygun, Basak E.; Izamis, Maria-Louisa; Toner, Mehmet; Yarmush, Martin L.; Uygun, Korkut (2014)
      The realization of long–term human organ preservation will have groundbreaking effects on the current practice of transplantation. Herein we present a novel technique based on sub–zero non–freezing tissue preservation and ...
    • Supercooling as a Viable Non-Freezing Cell Preservation Method of Rat Hepatocytes 

      Usta, O. Berk; Kim, Yeonhee; Ozer, Sinan; Bruinsma, Bote G.; Lee, Jungwoo; Demir, Esin; Berendsen, Tim A.; Puts, Catheleyne F.; Izamis, Maria-Louisa; Uygun, Korkut; Uygun, Basak E.; Yarmush, Martin L. (Public Library of Science, 2013)
      Supercooling preservation holds the potential to drastically extend the preservation time of organs, tissues and engineered tissue products, and fragile cell types that do not lend themselves well to cryopreservation or ...
    • Tissue heterogeneity in structure and conductivity contribute to cell survival during irreversible electroporation ablation by “electric field sinks” 

      Golberg, Alexander; Bruinsma, Bote G.; Uygun, Basak E.; Yarmush, Martin L. (Nature Publishing Group, 2015)
      Irreversible electroporation (IRE) is an emerging, minimally invasive technique for solid tumors ablation, under clinical investigation for cancer therapy. IRE affects only the cell membrane, killing cells while preserving ...
    • Warm Ischemic Injury Is Reflected in the Release of Injury Markers during Cold Preservation of the Human Liver 

      Bruinsma, Bote G.; Wu, Wilson; Ozer, Sinan; Farmer, Adam; Markmann, James F.; Yeh, Heidi; Uygun, Korkut (Public Library of Science, 2015)
      Background: Liver transplantation plays a pivotal role in the treatment of patients with end-stage liver disease. Despite excellent outcomes, the field is strained by a severe shortage of viable liver grafts. To meet high ...