Now showing items 1-4 of 4

    • \(A\beta\) alters the connectivity of olfactory neurons in the absence of amyloid plaques in vivo 

      Cao, Luxiang; Schrank, Benjamin R.; Rodriguez, Steven; Benz, Eric G.; Moulia, Thomas W.; Rickenbacher, Gregory T.; Gomez, Alexis C.; Levites, Yona; Edwards, Sarah R.; Golde, Todd E.; Hyman, Bradley Theodore; Barnea, Gilad; Albers, Mark W (Nature Publishing Group, 2012)
      The amyloid beta peptide aggregates into amyloid plaques at presymptomatic stages of Alzheimer's disease, but the temporal relationship between plaque formation and neuronal dysfunction is poorly understood. Here we ...
    • Genome-Encoded Cytoplasmic Double-Stranded RNAs, Found in C9ORF72 ALS-FTD Brain, Propagate Neuronal Loss 

      Rodriguez, Steve; Sahin, Asli; Schrank, Benjamin R.; Al Lawati, Hawra; Costantino, Isabel; Benz, Eric; Fard, Darian; Albers, Alefiya; Cao, Luxiang; Gomez, Alexis; Evans, Kyle; Ratti, Elena; Cudkowicz, Merit; Frosch, Matthew; Talkowski, Michael; Sorger, Peter; Hyman, Bradley; Albers, Mark (Science Press / AAAS, 2021-07-07)
      Triggers of innate immune signaling in the CNS of amyotrophic lateral sclerosis and frontotemporal degeneration (ALS/FTD) patients remain elusive. We report the presence of cytoplasmic double-stranded RNA (cdsRNA), an ...
    • Loss of the V-ATPase B1 Subunit Isoform Expressed in Non-Neuronal Cells of the Mouse Olfactory Epithelium Impairs Olfactory Function 

      Paunescu, Teodor Gabriel; Rodriguez, Steven; Benz, Eric; McKee, Mary; Tyszkowski, Robert; Albers, Mark W.; Brown, Dennis (Public Library of Science, 2012)
      The vacuolar proton-pumping ATPase (V-ATPase) is the main mediator of intracellular organelle acidification and also regulates transmembrane proton (H+) secretion, which is necessary for an array of physiological functions ...
    • The Precision of Axon Targeting of Mouse Olfactory Sensory Neurons Requires the BACE1 Protease 

      Cao, Luxiang; Rickenbacher, Gregory T.; Rodriguez, Steven; Moulia, Thomas W.; Albers, Mark W. (Nature Publishing Group, 2012)
      The \(\beta\)-site amyloid precursor protein cleaving enzyme 1 (BACE1) is necessary to generate the A\(\beta\) peptide, which is implicated in Alzheimer's disease pathology. Studies show that the expression of BACE1 and ...