Now showing items 1-4 of 4

    • Absorption of Manganese and Iron in a Mouse Model of Hemochromatosis 

      Kim, Jonghan; Buckett, Peter D.; Wessling-Resnick, Marianne (Public Library of Science, 2013)
      Hereditary hemochromatosis, an iron overload disease associated with excessive intestinal iron absorption, is commonly caused by loss of HFE gene function. Both iron and manganese absorption are regulated by iron status, ...
    • Ferristatin II Promotes Degradation of Transferrin Receptor-1 In Vitro and In Vivo 

      Byrne, Shaina L.; Buckett, Peter D.; Kim, Jonghan; Luo, Flora; Sanford, Jack; Chen, Juxing; Enns, Caroline; Wessling-Resnick, Marianne (Public Library of Science, 2013)
      Previous studies have shown that the small molecule iron transport inhibitor ferristatin (NSC30611) acts by down-regulating transferrin receptor-1 (TfR1) via receptor degradation. In this investigation, we show that another ...
    • Ingestion of Mn and Pb by rats during and after pregnancy alters iron metabolism and behavior in offspring 

      Molina, Ramon M.; Phattanarudee, Siripan; Kim, Jonghan; Thompson, Khristy J.; Wessling-Resnick, Marianne; Maher, Timothy Richard; Brain, Joseph David (Elsevier BV, 2011)
      Manganese (Mn) and lead (Pb) exposures during developmental period can impair development by direct neurotoxicity or through interaction with iron metabolism. Therefore, we examined the effects of maternal ingestion of Mn ...
    • Iron-Responsive Olfactory Uptake of Manganese Improves Motor Function Deficits Associated with Iron Deficiency 

      Kim, Jonghan; Li, Yuan; Buckett, Peter D.; Böhlke, Mark; Thompson, Khristy J.; Takahashi, Masaya; Maher, Timothy J.; Wessling-Resnick, Marianne (Public Library of Science, 2012)
      Iron-responsive manganese uptake is increased in iron-deficient rats, suggesting that toxicity related to manganese exposure could be modified by iron status. To explore possible interactions, the distribution of ...