Browsing by Author "Song, Yan"
Now showing items 1-6 of 6
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Development and Preclinical Validation of a Novel Covalent Ubiquitin Receptor Rpn13 Degrader in Multiple Myeloma
Song, Yan; Wu, Lei; Ray, Arghya; Li, Deyao; Du, Ting; Qi, Jun; Chauhan, Dharminder; Park, Paul; Picaud, Sarah; Wimalasena, Virangika; Filippakopoulos, Panagis; Anderson, Kenneth (Springer Science and Business Media LLC, 2019-04-08)Proteasome inhibition is an effective treatment for multiple myeloma (MM); however, targeting different components of the ubiquitin–proteasome system (UPS) remains elusive. Our RNA-interference studies identified ... -
Identification and Validation of Ecto-5' Nucleotidase as an Immunotherapeutic Target in Multiple Myeloma
Ray, Arghya; Song, Yan; Du, Ting; Buon, Leutz; Tai, Yu-Tzu; Chauhan, Dharminder; Anderson, Kenneth (Springer Science and Business Media LLC, 2022-04-01)Interaction of plasmacytoid dendritic cells (pDCs) with multiple myeloma (MM) cells, T- or NK-effector cells in the bone marrow (BM) microenvironment induces tumor cell growth, as well as inhibits innate and adaptive immune ... -
A Novel Hypoxia-Selective Epigenetic Agent RRx-001 Triggers Apoptosis and Overcomes Drug Resistance in Multiple Myeloma Cells
Das, Deepika Sharma; Ray, Arghya; Das, Abhishek; Song, Yan; Oronsky, Bryan; Richardson, Paul; Scicinski, Jan; Chauhan, Dharminder; Anderson, Kenneth C. (2016)The hypoxic bone-marrow (BM) microenvironment confers growth/survival and drug-resistance in multiple myeloma (MM) cells. Novel therapies targeting the MM cell in its hypoxic-BM milieu may overcome drug resistance. Recent ... -
Preclinical Validation of Alpha-Enolase (ENO1) As a Novel Immunometabolic Target in Multiple Myeloma
Ray, Arghya; Song, Yan; Chauhan, Dharminder; Anderson, Kenneth (Springer, 2020-02-05)Bone marrow plasmacytoid dendritic cells (pDCs) in patients with multiple myeloma (MM) promote tumor growth, survival, drug resistance, and immune suppression. Understanding the molecular signaling crosstalk among the tumor ... -
Proteomic Analysis Identifies Mechanism(s) of Overcoming Bortezomib-Resistance via Targeting Ubiquitin Receptor Rpn13
Du, Ting; Song, Yan; Ray, Arghya; Chauhan, Dharminder; Anderson, Kenneth (American Society of Hematology, 2018-05-18)Our prior study showed that inhibition of 19S proteasome-associated ubiquitin receptor Rpn13 can overcome bortezomib-resistance in MM cells. Here, we performed proteomic analysis of Rpn13 inhibitor (RA190)-treated MM cells ... -
Targeting Tryptophan Catabolic Kynurenine Pathway Enhances Antitumor Immunity and Cytotoxicity in Multiple Myeloma
Ray, Arghya; Song, Yan; Du, Ting; Tai, Yu-Tzu; Chauhan, Dharminder; Anderson, Kenneth (Springer Science and Business Media LLC, 2019-08-28)