Now showing items 1-5 of 5

    • Decreased Cerebrovascular Brain-Derived Neurotrophic Factor–Mediated Neuroprotection in the Diabetic Brain 

      Navaratna, Deepti; Guo, Shu-Zhen; Hayakawa, Kazhuhide; Wang, Xiaoying; Gerhardinger, Chiara; Lo, Eng H. (American Diabetes Association, 2011)
      Objective: Diabetes is an independent risk factor for stroke. However, the underlying mechanism of how diabetes confers that this risk is not fully understood. We hypothesize that secretion of neurotrophic factors by the ...
    • IL-1\(\beta\) Is Upregulated in the Diabetic Retina and Retinal Vessels: Cell-Specific Effect of High Glucose and IL-1\(\beta\) Autostimulation 

      Liu, Yang; Biarnés Costa, Montserrat; Gerhardinger, Chiara (Public Library of Science, 2012)
      Many molecular and cellular abnormalities detected in the diabetic retina support a role for IL-1\(\beta\)-driven neuroinflammation in the pathogenesis of diabetic retinopathy. IL-1\(\beta\) is well known for its role in ...
    • In vivo Ebola virus infection leads to a strong innate response in circulating immune cells 

      Caballero, Ignacio S.; Honko, Anna N.; Gire, Stephen K.; Winnicki, Sarah M.; Melé, Marta; Gerhardinger, Chiara; Lin, Aaron E.; Rinn, John L.; Sabeti, Pardis C.; Hensley, Lisa E.; Connor, John H. (BioMed Central, 2016)
      Background: Ebola virus is the causative agent of a severe syndrome in humans with a fatality rate that can approach 90 %. During infection, the host immune response is thought to become dysregulated, but the mechanisms ...
    • Multiple knockout mouse models reveal lincRNAs are required for life and brain development 

      Sauvageau, Martin; Goff, Loyal A; Lodato, Simona; Bonev, Boyan; Groff, Abigail F; Gerhardinger, Chiara; Sanchez-Gomez, Diana B; Hacisuleyman, Ezgi; Li, Eric; Spence, Matthew; Liapis, Stephen C; Mallard, William; Morse, Michael; Swerdel, Mavis R; D’Ecclessis, Michael F; Moore, Jennifer C; Lai, Venus; Gong, Guochun; Yancopoulos, George D; Frendewey, David; Kellis, Manolis; Hart, Ronald P; Valenzuela, David M; Arlotta, Paola; Rinn, John L (eLife Sciences Publications, Ltd, 2013)
      Many studies are uncovering functional roles for long noncoding RNAs (lncRNAs), yet few have been tested for in vivo relevance through genetic ablation in animal models. To investigate the functional relevance of lncRNAs ...
    • The Transforming Growth Factor-β Pathway is a Common Target of Drugs that Prevent Experimental Diabetic Retinopathy 

      Gerhardinger, Chiara; Dagher, Zeina; Sebastiani, Paola; Park, Yong Seek; Lorenzi, Mara (American Diabetes Association, 2009)
      OBJECTIVE-- Prevention of diabetic retinopathy would benefit from availability of drugs that preempt the effects of hyperglycemia on retinal vessels. We aimed to identify candidate drug targets by investigating the molecular ...