Browsing by Author "Mandl, Kenneth"
Now showing items 1-20 of 47
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Adverse drug events in the outpatient setting: an 11-year national analysis
Bourgeois, Florence Tanya; Shannon, Michael W.; Valim, Clarissa; Mandl, Kenneth David (Wiley-Blackwell, 2010)Purpose: Adverse drug events (ADEs) are a common complication of medical care resulting in high morbidity and medical expenditure. Population level estimates of outpatient ADEs are limited. Our objective was to provide ... -
Air Travel and the Spread of Influenza: Authors' Reply
Brownstein, John Samuel; Mandl, Kenneth David; Wolfe, Cecily J (Public Library of Science, 2006) -
App Store for EHRs and Patients Both
Franckle, Travers; Haas, Daniel; Mandl, Kenneth D. (American Medical Informatics Association, 2013)The Substitutable Medical Applications, Reusable Technologies (SMART) Platforms project ( www.smartplatforms.org ) seeks to develop an iPhone-like health information technology platform with substitutable apps constructed ... -
Are Meaningful Use Stage 2 certified EHRs ready for interoperability? Findings from the SMART C-CDA Collaborative
D'Amore, John D; Mandel, Joshua C; Kreda, David A; Swain, Ashley; Koromia, George A; Sundareswaran, Sumesh; Alschuler, Liora; Dolin, Robert H; Mandl, Kenneth D; Kohane, Isaac S; Ramoni, Rachel B (BMJ Publishing Group, 2014)Background and objective Upgrades to electronic health record (EHR) systems scheduled to be introduced in the USA in 2014 will advance document interoperability between care providers. Specifically, the second stage of the ... -
Automated real time constant-specificity surveillance for disease outbreaks
Wieland, Shannon C; Brownstein, John Samuel; Berger, Bonnie; Mandl, Kenneth David (BioMed Central, 2007)Background: For real time surveillance, detection of abnormal disease patterns is based on a difference between patterns observed, and those predicted by models of historical data. The usefulness of outbreak detection ... -
A Biosurveillance-driven Home Score to Guide Strep Pharyngitis Treatment
Fine, Andrew; Nizet, Victor; Mandl, Kenneth (University of Illinois at Chicago Library, 2013)Objective: 1. To derive and validate an accurate clinical prediction model (“home score”) to estimate a patient’s risk of group A streptococcal (GAS) pharyngitis before a health care visit based only on history and real-time ... -
Breaking the News or Fueling the Epidemic? Temporal Association between News Media Report Volume and Opioid-Related Mortality
Dasgupta, Nabarun; Mandl, Kenneth David; Brownstein, John Samuel (Public Library of Science, 2009)Background: Historical studies of news media have suggested an association between reporting and increased drug abuse. Period effects for substance use have been documented for different classes of legal and illicit ... -
C3-PRO: Connecting ResearchKit to the Health System Using i2b2 and FHIR
Pfiffner, Pascal B.; Pinyol, Isaac; Natter, Marc D.; Mandl, Kenneth D. (Public Library of Science, 2016)A renewed interest by consumer information technology giants in the healthcare domain is focused on transforming smartphones into personal health data storage devices. With the introduction of the open source ResearchKit, ... -
ClinicalTrials.gov as a Data Source for Semi-Automated Point-Of-Care Trial Eligibility Screening
Pfiffner, Pascal B.; Oh, JiWon; Miller, Timothy A.; Mandl, Kenneth D. (Public Library of Science, 2014)Background: Implementing semi-automated processes to efficiently match patients to clinical trials at the point of care requires both detailed patient data and authoritative information about open studies. Objective: To ... -
Comparative Effectiveness Research: An Empirical Study of Trials Registered in ClinicalTrials.gov
Bourgeois, Florence Tanya; Murthy, Srinivas; Mandl, Kenneth David (Public Library of Science, 2012)Background: The $1.1 billion investment in comparative effectiveness research will reshape the evidence-base supporting decisions about treatment effectiveness, safety, and cost. Defining the current prevalence and ... -
Comparison of Drug Utilization Patterns in Observational Data: Antiepileptic Drugs in Pediatric Patients
Bourgeois, Florence Tanya; Olson, Karen Lea; Poduri, Annapurna; Mandl, Kenneth David (Springer Nature, 2015)Purpose: Physicians require information on the comparative benefits and harms of medications for optimal treatment decisions. However, this type of data is limited, especially for pediatric patients. Objective: Our aim ... -
Conflict of Interest Disclosure in Biomedical Research: A Review of Current Practices, Biases, and the Role of Public Registries in Improving Transparency
Dunn, Adam G.; Coiera, Enrico; Mandl, Kenneth David; Bourgeois, Florence Tanya (Springer Nature, 2016)Conflicts of interest held by researchers remain a focus of attention in clinical research. Biases related to these relationships have the potential to directly impact the quality of healthcare by influencing decision-making, ... -
Development of a Scalable Pharmacogenomic Clinical Decision Support Service
Fusaro, Vincent A.; Brownstein, Catherine; Wolf, Wendy; Clinton, Catherine; Savage, Sarah; Mandl, Kenneth D.; Margulies, David; Manzi, Shannon (American Medical Informatics Association, 2013)Advances in sequencing technology are making genomic data more accessible within the healthcare environment. Published pharmacogenetic guidelines attempt to provide a clinical context for specific genomic variants; however, ... -
The Drug Data to Knowledge Pipeline: Large-Scale Claims Data Classification for Pharmacologic Insight
Homer, Mark L.; Palmer, Nathan P.; Bodenreider, Olivier; Cami, Aurel; Chadwick, Laura; Mandl, Kenneth D. (American Medical Informatics Association, 2016)In biomedical informatics, assigning drug codes to categories is a common step in the analysis pipeline. Unfortunately, incomplete mappings are the norm rather than the exception with coverage values less than 85% not ... -
Early Detection of Poor Adherers to Statins: Applying Individualized Surveillance to Pay for Performance
Zimolzak, Andrew J.; Spettell, Claire M.; Fernandes, Joaquim; Fusaro, Vincent A.; Palmer, Nathan P.; Saria, Suchi; Kohane, Isaac S.; Jonikas, Magdalena A.; Mandl, Kenneth D. (Public Library of Science, 2013)Background: Medication nonadherence costs $300 billion annually in the US. Medicare Advantage plans have a financial incentive to increase medication adherence among members because the Centers for Medicare and Medicaid ... -
Effects of a Law against Early Postpartum Discharge on Newborn Follow-up, Adverse Events, and HMO Expenditures
Madden, Jeanne Marie; Soumerai, Stephen Bertram; Lieu, Tracy; Mandl, Kenneth David; Zhang, Fang; Ross-Degnan, Dennis (New England Journal of Medicine (NEJM/MMS), 2002)BACKGROUND Concern about harm to newborns from early postpartum discharges led to laws establishing minimum hospital stays in the mid-1990s. We evaluated the effects of an early-discharge protocol (a hospital stay of one ... -
The Effects of Industry Sponsorship on Comparator Selection in Trial Registrations for Neuropsychiatric Conditions in Children
Dunn, Adam G.; Mandl, Kenneth D.; Coiera, Enrico; Bourgeois, Florence T. (Public Library of Science, 2013)Pediatric populations continue to be understudied in clinical drug trials despite the increasing use of pharmacotherapy in children, particularly with psychotropic drugs. Most pertinent to the clinical selection of drug ... -
Electronic Patient-Physician Communication: Problems and Promise
Mandl, Kenneth David; Kohane, Isaac Samuel; Brandt, Allan M. (American College of Physicians, 1998)A critical mass of Internet users will soon enable wide diffusion of electronic communication within medical practice. E-mail between physicians and patients offers important opportunities for better communication. Linking ... -
Empirical Evidence for the Effect of Airline Travel on Inter-Regional Influenza Spread in the United States
Wolfe, Cecily J; Galvani, Alison; Brownstein, John Samuel; Mandl, Kenneth David (Public Library of Science, 2006)Background: The influence of air travel on influenza spread has been the subject of numerous investigations using simulation, but very little empirical evidence has been provided. Understanding the role of airline travel ... -
Evaluation of Influenza Prevention in the Workplace Using a Personally Controlled Health Record: Randomized Controlled Trial
Bourgeois, Florence Tanya; Simons, William; Olson, Karen Lea; Brownstein, John Samuel; Mandl, Kenneth David (JMIR Publications Inc., 2008)Background: Personally controlled health records (PCHRs) are accessible over the Internet and allow individuals to maintain and manage a secure copy of their medical data. These records provide a new opportunity to provide ...