Now showing items 1-12 of 12

    • Comparative Acute Efficacy and Tolerability of OROS and Immediate Release Formulations of Methylphenidate in the Treatment of Adults with Attention-Deficit/Hyperactivity Disorder 

      Biederman, Joseph; Mick, Eric Owen; Surman, Craig B.H.; Doyle, Robert L.; Hammerness, Paul Graves; Michel, Evan; Martin, Jessica; Spencer, Thomas J. (BioMed Central, 2007)
      Background: The main aim of this study was to compare the safety and efficacy of IR MPH administered three times daily to those of once daily OROS-MPH. Methods: Subjects were outpatient adults satisfying full diagnostic ...
    • Discriminant and Concurrent Validity of a Simplified DSM-Based Structured Diagnostic Instrument for the Assessment of Autism Spectrum Disorders in Youth and Young Adults 

      Petty, Carter R; Galdo, Maribel; Kotarski, Meghan; Caruso, Janet; Meller, Benjamin; Joshi, Gagan; Fried, Ronna; Wozniak, Janet Rose; Micco, Jamie Ann; Henin, Aude I.; Doyle, Robert L.; Faraone, Stephen V.; Biederman, Joseph (BioMed Central, 2011)
      Background: To evaluate the concurrent and discriminant validity of a brief DSM-based structured diagnostic interview for referred individuals with autism spectrum disorders (ASDs). Methods: To test concurrent validity, ...
    • Dopamine Transporter 3'UTR VNTR Genotype is a Marker of Performance on Executive Function Tasks in Children with ADHD 

      Karama, Sherif; Grizenko, Natalie; Sonuga-Barke, Edmund; Mbekou, Valentin; Polotskaia, Anna; Ter-Stepanian, Marina; De Guzman, Rosherrie; Bellingham, Johanne; Sengupta, Sarojini; Joober, Ridha; Doyle, Alysa Emily; Biederman, Joseph (BioMed Central, 2008)
      Background: Attention-Deficit/Hyperactivity Disorder (ADHD) is a heterogeneous disorder from both clinical and pathogenic viewpoints. Executive function deficits are considered among the most important pathogenic pathways ...
    • Efficacy of Atomoxetine in Adult Attention-Deficit/Hyperactivity Disorder: A Drug-placebo Response Curve Analysis 

      Faraone, Stephen V.; Biederman, Joseph; Spencer, Thomas J.; Michelson, David; Adler, Lenard; Reimherr, Fred; Glatt, Stephen J (BioMed Central, 2005)
      Background: The objective of this study was to evaluate the efficacy of atomoxetine, a new and highly selective inhibitor of the norepinephrine transporter, in reducing symptoms of attention-deficit/hyperactivity disorder ...
    • Evidence for Genetic Association of RORB with Bipolar Disorder 

      McGrath, Casey L; Glatt, Stephen J; Sklar, Pamela B.; Le-Niculescu, Helen; Niculescu, Alexander B; Kuczenski, Ronald; Doyle, Alysa Emily; Biederman, Joseph; Mick, Eric Owen; Faraone, Stephen V.; Tsuang, Ming T. (BioMed Central, 2009)
      Background: Bipolar disorder, particularly in children, is characterized by rapid cycling and switching, making circadian clock genes plausible molecular underpinnings for bipolar disorder. We previously reported work ...
    • Family-based association study of the BDNF, COMT and serotonin transporter genes and DSM-IV bipolar-I disorder in children 

      Mick, Eric Owen; Wozniak, Janet Rose; Wilens, Timothy Edwin; Biederman, Joseph; Faraone, Stephen V. (BioMed Central, 2009)
      Background: Over the past decade pediatric bipolar disorder has gained recognition as a potentially more severe and heritable form of the disorder. In this report we test for association with genes coding brain-derived ...
    • Functional and structural brain correlates of risk for major depression in children with familial depression 

      Chai, Xiaoqian J.; Hirshfeld-Becker, Dina; Biederman, Joseph; Uchida, Mai; Doehrmann, Oliver; Leonard, Julia A.; Salvatore, John; Kenworthy, Tara; Brown, Ariel; Kagan, Elana; de los Angeles, Carlo; Whitfield-Gabrieli, Susan; Gabrieli, John D.E. (Elsevier, 2015)
      Despite growing evidence for atypical amygdala function and structure in major depression, it remains uncertain as to whether these brain differences reflect the clinical state of depression or neurobiological traits that ...
    • Genome-Wide Analysis of Copy Number Variants in Attention Deficit Hyperactivity Disorder: The Role of Rare Variants and Duplications at 15q13.3 

      Williams, Nigel M.; Franke, Barbara; Mick, Eric; Anney, Richard J.L.; Freitag, Christine M.; Gill, Michael; Thapar, Anita; O'Donovan, Michael C.; Owen, Michael J.; Holmans, Peter; Kent, Lindsey; Middleton, Frank; Zhang-James, Yanli; Liu, Lu; Meyer, Jobst; Nguyen, Thuy Trang; Romanos, Jasmin; Romanos, Marcel; Seitz, Christiane; Renner, Tobias J.; Walitza, Susanne; Warnke, Andreas; Palmason, Haukur; Buitelaar, Jan; Rommelse, Nanda; Vasquez, Alejandro Arias; Hawi, Ziarih; Langley, Kate; Sergeant, Joseph; Steinhausen, Hans-Christoph; Roeyers, Herbert; Biederman, Joseph; Zaharieva, Irina; Hakonarson, Hakon; Elia, Josephine; Lionel, Anath C.; Crosbie, Jennifer; Marshall, Christian R.; Schachar, Russell; Scherer, Stephen W.; Todorov, Alexandre; Smalley, Susan L.; Loo, Sandra; Nelson, Stanley; Shtir, Corina; Asherson, Philip; Reif, Andreas; Lesch, Klaus-Peter; Faraone, Stephen V. (American Psychiatric Publishing, 2013)
      Objective: Attention deficit hyperactivity disorder (ADHD) is a common, highly heritable psychiatric disorder. Because of its multifactorial etiology, however, identifying the genes involved has been difficult. The authors ...
    • High Loading of Polygenic Risk for ADHD in Children With Comorbid Aggression 

      Hamshere, Marian L.; Langley, Kate; Martin, Joanna; Agha, Sharifah Shameem; Stergiakouli, Evangelia; Anney, Richard J.L.; Buitelaar, Jan; Faraone, Stephen V.; Lesch, Klaus-Peter; Neale, Benjamin M.; Franke, Barbara; Sonuga-Barke, Edmund; Asherson, Philip; Merwood, Andrew; Kuntsi, Jonna; Medland, Sarah E.; Ripke, Stephan; Steinhausen, Hans-Christoph; Freitag, Christine; Reif, Andreas; Renner, Tobias J.; Romanos, Marcel; Romanos, Jasmin; Warnke, Andreas; Meyer, Jobst; Palmason, Haukur; Vasquez, Alejandro Arias; Lambregts-Rommelse, Nanda; Roeyers, Herbert; Biederman, Joseph; Doyle, Alysa E.; Hakonarson, Hakon; Rothenberger, Aribert; Banaschewski, Tobias; Oades, Robert D.; McGough, James J.; Kent, Lindsey; Williams, Nigel; Owen, Michael J.; Holmans, Peter; O’Donovan, Michael C.; Thapar, Anita (American Psychiatric Association, 2014)
      Objective: Although attention deficit hyperactivity disorder (ADHD) is highly heritable, genome-wide association studies (GWAS) have not yet identified any common genetic variants that contribute to risk. There is evidence ...
    • A Laboratory Driving Simulation for Assessment of Driving Behavior in Adults with ADHD: A Controlled Study 

      Monuteaux, Michael C; Reimer, Bryan; Coughlin, Joseph F; Aleardi, Megan; Dougherty, Meghan; Schoenfeld, Steven; Biederman, Joseph; Fried, Ronna; Surman, Craig B.H.; Spencer, Thomas J.; Faraone, Stephen V. (BioMed Central, 2007)
      Background: It is now estimated that attention deficit-hyperactivity disorder (ADHD) afflicts at least 4% of adults in the United States and is associated with high levels of morbidity and functional impairment. One key ...
    • Longitudinal Course of Deficient Emotional Self-Regulation CBCL Profile in Youth with ADHD: Prospective Controlled Study 

      Biederman, Joseph; Spencer, Thomas J.; Petty, Carter; Hyder, Laran L; O’Connor, Katherine B; Surman, Craig B.H.; Faraone, Stephen V. (Dove Medical Press, 2012)
      Background: While symptoms of deficient emotional self-regulation (DESR) have been long associated with attention-deficit/hyperactivity disorder (ADHD), there has been limited investigation of this aspect of the clinical ...
    • Postural sway and regional cerebellar volume in adults with attention-deficit/hyperactivity disorder 

      Hove, Michael J.; Zeffiro, Thomas A.; Biederman, Joseph; Li, Zhi; Schmahmann, Jeremy; Valera, Eve M. (Elsevier, 2015)
      Objective: Motor abnormalities, including impaired balance and increased postural sway, are commonly reported in children with ADHD, but have yet to be investigated in adults with ADHD. Furthermore, although these abnormalities ...