Browsing by Author "McDonald, Merry-Lynn N"

Now showing items 1-4 of 4

    • Clinical, physiologic, and radiographic factors contributing to development of hypoxemia in moderate to severe COPD: a cohort study 

      Wells, J. Michael; Estepar, Raul San Jose; McDonald, Merry-Lynn N.; Bhatt, Surya P.; Diaz, Alejandro A.; Bailey, William C.; Jacobson, Francine L.; Dransfield, Mark T.; Washko, George R.; Make, Barry J.; Casaburi, Richard; van Beek, Edwin J. R.; Hoffman, Eric A.; Sciurba, Frank C.; Crapo, James D.; Silverman, Edwin K.; Hersh, Craig P. (BioMed Central, 2016)
      Background: Hypoxemia is a major complication of COPD and is a strong predictor of mortality. We previously identified independent risk factors for the presence of resting hypoxemia in the COPDGene cohort. However, little ...

    • A comparative analysis of family-based and population-based association tests using whole genome sequence data 

      Zhou, Jin J; Yip, Wai-Ki; Cho, Michael H; Qiao, Dandi; McDonald, Merry-Lynn N; Laird, Nan M (BioMed Central, 2014)
      The revolution in next-generation sequencing has made obtaining both common and rare high-quality sequence variants across the entire genome feasible. Because researchers are now faced with the analytical challenges of ...

    • A Genome-wide analysis of the response to inhaled beta2-agonists in Chronic Obstructive Pulmonary Disease 

      Hardin, Megan; Cho, Michael H.; McDonald, Merry-Lynn; Wan, Emily; Lomas, David A.; Coxson, Harvey O.; MacNee, William; Vestbo, Jørgen; Yates, Julie C.; Agusti, Alvar; Calverley, Peter MA; Celli, Bartolome; Crim, Courtney; Rennard, Stephen; Wouters, Emiel; Bakke, Per; Bhatt, Surya P; Kim, Victor; Ramsdell, Joe; Regan, Elizabeth A.; Make, Barry J.; Hokanson, John E.; Crapo, James D.; Beaty, Terri H.; Hersh, Craig P. (2015)
      Short-acting β2-agonist bronchodilators are the most common medications used in treating chronic obstructive pulmonary disease (COPD). Genetic variants determining bronchodilator responsiveness (BDR) in COPD have not been ...

    • A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry 

      Lutz, Sharon M.; Cho, Michael H.; Young, Kendra; Hersh, Craig P.; Castaldi, Peter J.; McDonald, Merry-Lynn; Regan, Elizabeth; Mattheisen, Manuel; DeMeo, Dawn L.; Parker, Margaret; Foreman, Marilyn; Make, Barry J.; Jensen, Robert L.; Casaburi, Richard; Lomas, David A.; Bhatt, Surya P.; Bakke, Per; Gulsvik, Amund; Crapo, James D.; Beaty, Terri H.; Laird, Nan M.; Lange, Christoph; Hokanson, John E.; Silverman, Edwin K. (BioMed Central, 2015)
      Background: Pulmonary function decline is a major contributor to morbidity and mortality among smokers. Post bronchodilator FEV1 and FEV1/FVC ratio are considered the standard assessment of airflow obstruction. We performed ...