Browsing by Author "Alsop, David"
Now showing items 1-20 of 73
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A 3T MR Imaging Investigation of the Topography of Whole Spinal Cord Atrophy in Multiple Sclerosis
Klein, Joshua Peter; Arora, A.; Neema, M; Healy, Brian Curran; Tauhid, Shahamat Syed; Goldberg-Zimring, D.; Chavarro-Nieto, C.; Stankiewicz, James; Cohen, Adam Brian; Buckle, G. J.; Houtchens, Maria K.; Ceccarelli, A.; Dell, E.; Guttmann, Charles R.G.; Alsop, David C.; Hackney, David Brian; Bakshi, Rohit (American Society of Neuroradiology (ASNR), 2011)Background and Purpose: Spinal cord atrophy is a common feature of MS. However, it is unknown which cord levels are most susceptible to atrophy. We performed whole cord imaging to identify the levels most susceptible to ... -
3 T MRI relaxometry detects T2 prolongation in the cerebral normal-appearing white matter in multiple sclerosis
Neema, Mohit; Goldberg-Zimring, Daniel; Guss, Zachary D.; Healy, Brian; Guttmann, Charles; Houtchens, Maria; Weiner, Howard; Horsfield, Mark A.; Hackney, David; Alsop, David; Bakshi, Rohit (Elsevier BV, 2009-07-01)MRI at 3 T has increased sensitivity in detecting overt multiple sclerosis (MS) brain lesions; a growing body of data suggests clinically relevant damage occurs in the normal-appearing white matter (NAWM). We tested a novel ... -
Aging, brain disease, and reserve: Implications for delirium
Jones, Richard Norman; Fong, Tamara G; Metzger, Eran Daniel; Tulebaev, Samir Raisovich; Yang, Frances Margaret; Alsop, David C.; Marcantonio, Edward Ralph; Cupples, L; Gottlieb, Gary L.; Inouye, Sharon (2010)Cognitive and brain reserve are well studied in the context of age-associated cognitive impairment and dementia. However, there is a paucity of research that examines the role of cognitive or brain reserve in delirium. ... -
Aging, Brain Disease, and Reserve: Implications for Delirium
Jones, Richard; Fong, Tamara; Metzger, Eran; Tulebaev, Samir; Yang, Frances; Alsop, David; Marcantonio, Edward; Cupples, L Adrienne; Gottlieb, Gary; Inouye, Sharon (Elsevier BV, 2010-02)Cognitive and brain reserve are well studied in the context of age-associated cognitive impairment and dementia. However, there is a paucity of research that examines the role of cognitive or brain reserve in delirium. ... -
Alzheimer's-Related Cortical Atrophy Is Associated With Postoperative Delirium Severity in Persons Without Dementia
Racine, Annie M.; Fong, Tamara; Travison, Thomas; Jones, Richard N.; Gou, Yun; Vasunilashorn, Sarinnapha; Marcantonio, Edward; Alsop, David; Inouye, Sharon; Dickerson, Bradford (Elsevier BV, 2017-11)Patients with dementia due to Alzheimer’s disease (AD) have increased risk of developing delirium. This study investigated the relationship between a magnetic resonance imaging (MRI)-derived biomarker associated with ... -
Amide Proton Transfer Imaging With Improved Robustness to Magnetic Field Inhomogeneity and Magnetization Transfer Asymmetry Using Saturation With Frequency Alternating RF Irradiation
Scheidegger, Rachel; Vinogradov, Elena; Alsop, David (Wiley, 2011-11)Amide proton transfer (APT) imaging has shown promise as an indicator of tissue pH and as a marker for brain tumors. Sources of error in APT measurements include direct water saturation, and magnetization transfer (MT) ... -
Anti-S1P Antibody as a Novel Therapeutic Strategy for VEGFR TKI-Resistant Renal Cancer
Zhang, Liang; Wang, Xiaoen; Bullock, Andrea; Callea, Marcella; Shah, H.; Song, Jiaxi; Moreno, K.; Visentin, B.; Deutschman, D.; Alsop, David; Atkins, M. B.; Mier, James; Signoretti, Sabina; Bhasin, Manoj; Sabbadini, R. A.; Bhatt, Rupal (American Association for Cancer Research (AACR), 2015-04-15)Purpose VEGFR2 tyrosine kinase inhibition (TKI) is a valuable treatment approach for patients with metastatic RCC. However, resistance to treatment is inevitable. Identification of novel targets could lead to better ... -
Arterial Spin Labeling Blood Flow MRI: Its Role in the Early Characterization of Alzheimer's Disease
Alsop, David; Dai, Weiying; Grossman, Murray; Detre, John A. (IOS Press, 2010-05-26)Arterial spin labeling (ASL) enables the noninvasive, quantitative imaging of cerebral blood flow using standard magnetic resonance imaging (MRI) equipment. Because it requires no contrast injection, ASL can add resting ... -
Arterial Spin-Label Imaging in Patients with Normal Bolus Perfusion-weighted MR Imaging Findings: Pilot Identification of the Borderzone Sign
Zaharchuk, Greg; Bammer, Roland; Straka, Matus; Shankaranarayan, Ajit; Alsop, David; Fischbein, Nancy J.; Atlas, Scott W.; Moseley, Michael E. (Radiological Society of North America (RSNA), 2009-09)Purpose To determine whether perfusion abnormalities are depicted on arterial spin-labeling (ASL) images obtained in patients with normal bolus perfusion-weighted (PW) magnetic resonance (MR) imaging findings. Materials ... -
Arterial Spin-labeling MR Imaging of Renal Masses: Correlation with Histopathologic Findings
Lanzman, Rotem S.; Robson, Phil M.; Sun, Maryellen R.; Patel, Amish D.; Mentore, Kimiknu; Wagner, Andrew; Genega, Elizabeth M.; Rofsky, Neil M.; Alsop, David; Pedrosa, Ivan (Radiological Society of North America (RSNA), 2012-12)Purpose: To assess the value of arterial spin-labeling (ASL) perfusion magnetic resonance (MR) imaging in the characterization of solid renal masses by using histopathologic findings as the standard of reference. Materials ... -
Assessment of functional development in normal infant brain using arterial spin labeled perfusion MRI
Wang, Ze; Fernández-Seara, María; Alsop, David; Liu, Wen-Ching; Flax, Judy F.; Benasich, April A.; Detre, John A. (Elsevier BV, 2008-02)Arterial spin labeled (ASL) perfusion MRI provides a noninvasive approach for longitudinal imaging of regional brain function in infants. In the present study, continuous ASL (CASL) perfusion MRI was carried out in normally ... -
Association Between Hospital Readmission and Acute and Sustained Delays in Functional Recovery During 18 Months After Elective Surgery: The Successful Aging after Elective Surgery Study
Pisani, Margaret A.; Albuquerque, Asha; Marcantonio, Edward; Jones, Richard N.; Gou, Ray Yun; Fong, Tamara; Schmitt, Eva M.; Tommet, Douglas; Isaza Aizpurua, Ilean I.; Alsop, David; Inouye, Sharon; Travison, Thomas (Wiley, 2017-01)Objectives: To examine the effect of hospital readmission on functional recovery after elective surgery in older adults. Design: Prospective cohort of individuals aged 70 and older undergoing elective surgery, enrolled ... -
Association cortex hypoperfusion in mild dementia with Lewy bodies: a potential indicator of cholinergic dysfunction?
Fong, Tamara G; Inouye, Sharon; Dai, Weiying; Press, Daniel; Alsop, David C. (Springer Science + Business Media, 2010)Dementia with Lewy bodies (DLB) is often associated with occipital hypometabolism or hypoperfusion, as well as deficits in cholinergic neurotransmission. In this study, 11 mild DLB, 16 mild AD and 16 age-matched controls ... -
Association of Blood Pressure Elevation and Nocturnal Dipping With Brain Atrophy, Perfusion and Functional Measures in Stroke and Nonstroke Individuals
Hajjar, Ihab; Zhao, Peng; Alsop, David; Abduljalil, Amir; Selim, Magdy; Novak, Peter; Novak, Vera (Oxford University Press (OUP), 2010-01)Background Although blood pressure elevation and lower nocturnal dipping both increase vascular risk, it is not known if either or both are also associated with brain atrophy, cerebral perfusion, and functional ... -
Atorvastatin Therapy is Associated with Greater and Faster Cerebral Hemodynamic Response
Xu, Guofan; Fitzgerald, Michele E.; Wen, Zhifei; Fain, Sean B.; Alsop, David; Carroll, Timothy; Ries, Michele L.; Rowley, Howard A.; Sager, Mark A.; Asthana, Sanjay; Johnson, Sterling C.; Carlsson, Cynthia M. (Springer Science and Business Media LLC, 2008-06)Hypercholesterolemia in midlife increases the risk of subsequent cognitive decline, neurovascular disease, and Alzheimer’s disease (AD), and statin use is associated with reduced prevalence of these outcomes. While statins ... -
Attentional modulation of emotional stimulus processing: An fMRI study using emotional expectancy
Bermpohl, Felix; Pascual-Leone, Alvaro; Amedi, Amir; Merabet, Lotfi B; Fregni, Felipe; Gaab, Nadine; Alsop, David C.; Schlaug, Gottfried; Northoff, Georg (Wiley-Blackwell, 2006)We used emotional expectancy to study attentional modulation in the processing of emotional stimuli. During functional magnetic resonance imaging (fMRI), volunteers saw emotional and neutral expectancy cues signaling the ... -
Brain MR Imaging at Ultra-Low Radiofrequency Power
Sarkar, Subhendra N.; Alsop, David; Madhuranthakam, Ananth J.; Busse, Reed F.; Robson, Philip M.; Rofsky, Neil M.; Hackney, David (Radiological Society of North America (RSNA), 2011-05)Purpose: To explore the lower limits for radiofrequency (RF) power-induced specific absorption rate (SAR) achievable at 1.5 T for brain magnetic resonance (MR) imaging without loss of tissue signal or contrast present in ... -
Cerebral Blood Flow Velocity and Periventricular White Matter Hyperintensities in Type 2 Diabetes
Novak, Vera; Last, David; Alsop, David; Abduljalil, Amir; Hu, Kun; Lepicovsky, Lukas; Cavallerano, Jerry; Lipsitz, Lewis (American Diabetes Association, 2006-07)OBJECTIVE Diabetes increases the risk for cerebromicrovascular disease, possibly through its effects on blood flow regulation. The aim of this study was to assess the effects of type 2 diabetes on blood flow velocities ... -
Cerebrospinal fluid matrix metalloproteinase-9 increases during treatment of recurrent malignant gliomas
Wong, Eric; Alsop, David; Lee, Diana; Tam, Angela; Barron, Loretta; Bloom, Julianne; Gautam, Shiva; Wu, Julian K. (Springer Science and Business Media LLC, 2008-01-11)Background Matrix metalloproteinases (MMPs) are enzymes that promote tumor invasion and angiogenesis by enzymatically remodeling the extracellular matrix. MMP-2 and MMP-9 are the most abundant forms of MMPs in malignant ... -
Cognitive and Brain Reserve and the Risk of Postoperative Delirium in Older Patients: Analysis of Data From a Prospective Observational Study
Saczynski, Jane; Inouye, Sharon; Kosar, Cyrus; Tommet, Doug; Marcantonio, Edward; Fong, Tamara; Hshieh, Tammy; Vasunilashorn, Sarinnapha; Metzger, Eran; Schmitt, Eva; Alsop, David; Jones, Richard N (Elsevier BV, 2014-11-01)Background Cognitive and brain reserve theories suggest that aspects of neural architecture or cognitive processes modify the impact of neuropathological processes on cognitive outcomes. While frequently studied in the ...