Now showing items 1-11 of 11

    • A 3T MR Imaging Investigation of the Topography of Whole Spinal Cord Atrophy in Multiple Sclerosis 

      Klein, Joshua Peter; Arora, A.; Neema, M; Healy, Brian Curran; Tauhid, Shahamat Syed; Goldberg-Zimring, D.; Chavarro-Nieto, C.; Stankiewicz, James; Cohen, Adam Brian; Buckle, G. J.; Houtchens, Maria K.; Ceccarelli, A.; Dell, E.; Guttmann, Charles R.G.; Alsop, David C.; Hackney, David Brian; Bakshi, Rohit (American Society of Neuroradiology (ASNR), 2011)
      Background and Purpose: Spinal cord atrophy is a common feature of MS. However, it is unknown which cord levels are most susceptible to atrophy. We performed whole cord imaging to identify the levels most susceptible to ...
    • Aging, brain disease, and reserve: Implications for delirium 

      Jones, Richard Norman; Fong, Tamara G; Metzger, Eran Daniel; Tulebaev, Samir Raisovich; Yang, Frances Margaret; Alsop, David C.; Marcantonio, Edward Ralph; Cupples, L; Gottlieb, Gary L.; Inouye, Sharon (2010)
      Cognitive and brain reserve are well studied in the context of age-associated cognitive impairment and dementia. However, there is a paucity of research that examines the role of cognitive or brain reserve in delirium. ...
    • Association cortex hypoperfusion in mild dementia with Lewy bodies: a potential indicator of cholinergic dysfunction? 

      Fong, Tamara G; Inouye, Sharon; Dai, Weiying; Press, Daniel; Alsop, David C. (Springer Science + Business Media, 2010)
      Dementia with Lewy bodies (DLB) is often associated with occipital hypometabolism or hypoperfusion, as well as deficits in cholinergic neurotransmission. In this study, 11 mild DLB, 16 mild AD and 16 age-matched controls ...
    • Attentional modulation of emotional stimulus processing: An fMRI study using emotional expectancy 

      Bermpohl, Felix; Pascual-Leone, Alvaro; Amedi, Amir; Merabet, Lotfi B; Fregni, Felipe; Gaab, Nadine; Alsop, David C.; Schlaug, Gottfried; Northoff, Georg (Wiley-Blackwell, 2006)
      We used emotional expectancy to study attentional modulation in the processing of emotional stimuli. During functional magnetic resonance imaging (fMRI), volunteers saw emotional and neutral expectancy cues signaling the ...
    • Cox-2 Inhibition Enhances the Activity of Sunitinib in Human Renal Cell Carcinoma Xenografts 

      Wang, Xiaoen; Zhang, L; O'Neill, A; Bahamon, B; Alsop, David C.; Mier, James W.; Goldberg, S. Nahum; Signoretti, Sabina; Atkins, M B; Wood, C G; Bhatt, Rupal Satish (Nature Publishing Group, 2013)
      Background: Sunitinib (Su), a tyrosine kinase inhibitor of VEGFR, is effective at producing tumour response in clear cell renal cell carcinoma (cRCC), but resistance to therapy is inevitable. As COX-2 is a known mediator ...
    • High Dose Intermittent Sorafenib Shows Improved Efficacy Over Conventional Continuous Dose in Renal Cell Carcinoma 

      Wang, Xiaoen; Zhang, Liang; Goldberg, S. Nahum; Bhasin, Manoj; Brown, Victoria; Alsop, David C.; Signoretti, Sabina; Mier, James W.; Atkins, Michael B.; Bhatt, Rupal Satish (BioMed Central, 2011)
      Background: Renal cell carcinoma (RCC) responds to agents that inhibit vascular endothelial growth factor (VEGF) pathway. Sorafenib, a multikinase inhibitor of VEGF receptor, is effective at producing tumor responses and ...
    • Inhibition of ALK1 signaling with dalantercept combined with VEGFR TKI leads to tumor stasis in renal cell carcinoma 

      Wang, Xiaoen; Solban, Nicolas; Khanna, Prateek; Callea, Marcella; Song, Jiaxi; Alsop, David C.; Pearsall, R. Scott; Atkins, Michael B.; Mier, James W.; Signoretti, Sabina; Alimzhanov, Marat; Kumar, Ravi; Bhasin, Manoj K.; Bhatt, Rupal S. (Impact Journals LLC, 2016)
      Treatment of metastatic renal cell carcinoma (mRCC) with agents that block signaling through vascular endothelial growth factor receptor 2 (VEGFR2) induces disease regression or stabilization in some patients; however, ...
    • Maximizing Clinical Research Participation in Vulnerable Older Persons: Identification of Barriers and Motivators 

      Marcantonio, Edward Ralph; Aneja, Jasneet; Jones, Richard Norman; Alsop, David C.; Fong, Tamara G; Crosby, Gregory; Culley, Deborah Jean; Cupples, L. Adrienne; Inouye, Sharon (Wiley-Blackwell, 2008)
      OBJECTIVES: To identify barriers and motivators to participation in long-term clinical research by high-risk elderly people and to develop procedures to maximize recruitment and retention. DESIGN: Quantitative and ...
    • Novel Risk Markers and Long-Term Outcomes of Delirium: The Successful Aging after Elective Surgery (SAGES) Study Design and Methods 

      Schmitt, Eva M.; Marcantonio, Edward Ralph; Alsop, David C.; Jones, Richard Norman; Rogers, Selwyn O.; Fong, Tamara G; Metzger, Eran Daniel; Inouye, Sharon (Elsevier BV, 2012)
      Objectives: Delirium, a costly, life-threatening, and potentially preventable condition, is a common complication for older adults following major surgery. Although the basic epidemiology of delirium after surgery has been ...
    • Phase I study of low-dose metronomic temozolomide for recurrent malignant gliomas 

      Wong, Eric T.; Timmons, Joshua; Callahan, Amy; O’Loughlin, Lauren; Giarusso, Bridget; Alsop, David C. (BioMed Central, 2016)
      Background: The treatment goal for recurrent malignant gliomas centers on disease stabilization while minimizing therapy-related side effects. Metronomic dosing of cytotoxic chemotherapy has emerged as a promising option ...
    • Resistance of Renal Cell Carcinoma to Sorafenib Is Mediated by Potentially Reversible Gene Expression 

      Bhasin, Manoj; Schor-Bardach, Rachel; Collins, Michael P.; Zhang, Liang; Wang, Xiaoen; Panka, David Joel; Putheti, Prabhakar; Signoretti, Sabina; Alsop, David C.; Libermann, Towia Aron; Atkins, Michael B.; Mier, James W.; Goldberg, S. Nahum; Bhatt, Rupal Satish (Public Library of Science, 2011)
      Purpose: Resistance to antiangiogenic therapy is an important clinical problem. We examined whether resistance occurs at least in part via reversible, physiologic changes in the tumor, or results solely from stable genetic ...