Now showing items 1-7 of 7

    • Broad Spectrum Antiangiogenic Treatment for Ocular Neovascular Diseases 

      Benny, Ofra; Nakai, Kei; Yoshimura, Takeru; Bazinet, Lauren; Akula, James Daniel; Nakao, Shintaro; Hafezi-Moghadam, Ali; Panigrahy, Dipak; Pakneshan, Pouya; D'Amato, Robert John (Public Library of Science, 2010)
      Pathological neovascularization is a hallmark of late stage neovascular (wet) age-related macular degeneration (AMD) and the leading cause of blindness in people over the age of 50 in the western world. The treatments focus ...
    • Cytochrome P450 2C8 ω3-long-chain polyunsaturated fatty acid metabolites increase mouse retinal pathologic neovascularization--brief report. 

      Shao, Zhuo; Fu, Zhong Jie; Stahl, A.; Joyal, Julie Anne; Hatton, Colin Paul; Juan, A.; Hurst, C.; Evans, L.; Cui, Z.; Pei, D.; Gong, Yan; Xu, D.; Tian, K.; Bogardus, H.; Edin, M. L.; Lih, F.; Sapieha, P.; Chen, Jing; Panigrahy, Dipak; Hellstrom, A.; Zeldin, D. C.; Smith, Lois Elaine Hodgson (Ovid Technologies (Wolters Kluwer Health), 2014)
      OBJECTIVE: Regulation of angiogenesis is critical for many diseases. Specifically, pathological retinal neovascularization, a major cause of blindness, is suppressed with dietary ω3-long-chain polyunsaturated fatty acids ...
    • Cytochrome P450-Derived Eicosanoids: The Neglected Pathway in Cancer 

      Panigrahy, Dipak; Kaipainen, Arja; Greene, Emily R.; Huang, Sui (Springer US, 2010)
      Endogenously produced lipid autacoids are locally acting small molecule mediators that play a central role in the regulation of inflammation and tissue homeostasis. A well-studied group of autacoids are the products of ...
    • Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice 

      Panigrahy, Dipak; Edin, Matthew L.; Lee, Craig R.; Huang, Sui; Bielenberg, Diane; Butterfield, Catherine E.; Barnés, Carmen M.; Mammoto, Akiko; Mammoto, Tadanori; Luria, Ayala; Benny, Ofra; Chaponis, Deviney M.; Dudley, Andrew C.; Greene, Emily R.; Vergilio, Jo-Anne; Pietramaggiori, Giorgio; Scherer-Pietramaggiori, Sandra S.; Short, Sarah M.; Seth, Meetu; Lih, Fred B.; Tomer, Kenneth B.; Yang, Jun; Schwendener, Reto A.; Hammock, Bruce D.; Falck, John R.; Manthati, Vijaya L.; Ingber, Donald Elliot; Kaipainen, Arja; D'Amore, Patricia Ann; Kieran, Mark W.; Zeldin, Darryl C. (American Society for Clinical Investigation, 2012)
      Epoxyeicosatrienoic acids (EETs) are small molecules produced by cytochrome P450 epoxygenases. They are lipid mediators that act as autocrine or paracrine factors to regulate inflammation and vascular tone. As a result, ...
    • Epoxyeicosatrienoic Acids Enhance Embryonic Haematopoiesis and Adult Marrow Engraftment 

      Li, Pulin; Lahvic, Jamie L.; Binder, Vera; Pugach, Emily K.; Riley, Elizabeth B.; Tamplin, Owen J.; Panigrahy, Dipak; Bowman, Teresa V.; Barrett, Francesca G.; Heffner, Garrett C.; McKinney-Freeman, Shannon; Schlaeger, Thorsten M.; Daley, George Q.; Zeldin, Darryl C.; Zon, Leonard I. (2015)
      Haematopoietic stem and progenitor cell (HSPC) transplant is a widely used treatment for life-threatening conditions including leukemia; however, the molecular mechanisms regulating HSPC engraftment of the recipient niche ...
    • PPAR\(\alpha\) Deficiency in Inflammatory Cells Suppresses Tumor Growth 

      Kaipainen, Arja; Kieran, Mark W.; Huang, Sui; Butterfield, Catherine; Bielenberg, Diane; Mostoslavsky, Gustavo; Mulligan, Richard Charles; Folkman, Judah; Panigrahy, Dipak (Public Library of Science, 2007)
      Inflammation in the tumor bed can either promote or inhibit tumor growth. Peroxisome proliferator-activated receptor (PPAR)\(\alpha\) is a central transcriptional suppressor of inflammation, and may therefore modulate tumor ...
    • Regulation of soluble neuropilin 1, an endogenous angiogenesis inhibitor, in liver development and regeneration 

      Panigrahy, Dipak; Adini, Irit; Mamluk, Roni; Levonyak, Nicholas; Bruns, Christiane J.; D'Amore, Patricia Ann; Klagsbrun, Michael; Bielenberg, Diane (Elsevier BV, 2014)
      Neuropilin-1 (NRP1) is a receptor for vascular endothelial growth factor (VEGF). A soluble isoform of Nrp1 (sNrp1) has not been described in the mouse. Our goal was to examine the expression of mouse sNrp1 during liver ...