Now showing items 1-11 of 11

    • B cell homeostasis and follicle confines are governed by fibroblastic reticular cells 

      Cremasco, Viviana; Woodruff, Matthew C.; Onder, Lucas; Cupovic, Jovana; Nieves-Bonilla, Janice M.; Schildberg, Frank A.; Chang, Jonathan; Cremasco, Floriana; Harvey, Christopher J.; Wucherpfennig, Kai; Ludewig, Burkhard; Carroll, Michael C.; Turley, Shannon J. (2014)
      Fibroblastic reticular cells (FRCs) are known to inhabit T cell-rich areas of lymphoid organs where they function to coordinate T cell and dendritic cell interactions. However, in vivo manipulation of FRCs has been limited ...
    • The CLEC-2–podoplanin axis controls fibroblastic reticular cell contractility and lymph node microarchitecture 

      Astarita, Jillian L.; Cremasco, Viviana; Fu, Jianxin; Darnell, Max C.; Peck, James R.; Nieves-Bonilla, Janice M.; Song, Kai; Woodruff, Matthew C.; Gogineni, Alvin; Onder, Lucas; Ludewig, Burkhard; Weimer, Robby M.; Carroll, Michael C.; Mooney, David J.; Xia, Lijun; Turley, Shannon J. (2014)
      In lymph nodes, fibroblastic reticular cells (FRCs) form a collagen-based reticular network that supports migratory dendritic cells (DCs) and T cells and transports lymph. A hallmark of FRCs is their propensity to contract ...
    • Clonal Analysis of Mucosal SIV-Specific CD8+ T Cell Responses 

      Sircar, Piya (2013-02-26)
      CD8+ T cells responses are critical in the immune defense against human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infection. A major challenge for vaccine development is that HIV/SIV can rapidly ...
    • Insights into the Transcriptional Identities of Lymph Node Stromal Cell Subsets Isolated from Resting and Inflamed Lymph Nodes 

      Malhotra, Deepali (2013-03-18)
      Non-hematopoietic stromal cells (SCs) promote and regulate adaptive immunity through numerous direct and indirect mechanisms. SCs construct and support the secondary lymphoid organs (SLOs) in which lymphocytes crawl on ...
    • Mutations in G protein β subunits promote transformation and kinase inhibitor resistance 

      Yoda, Akinori; Adelmant, Guillaume; Tamburini, Jerome; Chapuy, Bjoern; Shindoh, Nobuaki; Yoda, Yuka; Weigert, Oliver; Kopp, Nadja; Wu, Shuo-Chieh; Kim, Sunhee S; Liu, Huiyun; Tivey, Trevor; Christie, Amanda L; Elpek, Kutlu G; Card, Joseph; Gritsman, Kira; Gotlib, Jason; Deininger, Michael W; Makishima, Hideki; Turley, Shannon J.; Javidi-Sharifi, Nathalie; Maciejewski, Jaroslaw P; Jaiswal, Siddhartha; Ebert, Benjamin L.; Rodig, Scott J.; Tyner, Jeffrey W; Marto, Jarrod; Weinstock, David Marc; Lane, Andrew Alan (Nature Publishing Group, 2014)
      Activating mutations in genes encoding G protein α (Gα) subunits occur in 4-5% of all human cancers, but oncogenic alterations in Gβ subunits have not been defined. Here we demonstrate that recurrent mutations in the Gβ ...
    • Podoplanin: Emerging Functions in Development, the Immune System, and Cancer 

      Astarita, Jillian Leigh; Acton, Sophie E.; Turley, Shannon J. (Frontiers Research Foundation, 2012)
      Podoplanin (PDPN) is a well-conserved, mucin-type transmembrane protein expressed in multiple tissues during ontogeny and in adult animals, including the brain, heart, kidney, lungs, osteoblasts, and lymphoid organs. Studies ...
    • Reproducible Isolation of Lymph Node Stromal Cells Reveals Site-Dependent Differences in Fibroblastic Reticular Cells 

      Fletcher, Anne Louise; Malhotra, Deepali; Acton, Sophie E.; Lukacs-Kornek, Veronika; Bellemare-Pelletier, Angelique; Curry, Mark; Armant, Myriam Anne; Turley, Shannon J. (Frontiers Research Foundation, 2011)
      Within lymph nodes, non-hematopoietic stromal cells organize and interact with leukocytes in an immunologically important manner. In addition to organizing T and B cell segregation and expressing lymphocyte survival factors, ...
    • The role of the podoplanin-CLEC-2 pathway in stromal cell regulation of dendritic cell motility and lymph node architecture 

      Astarita, Jillian Leigh (2014-10-21)
      In addition to leukocytes, secondary lymphoid organs are populated by non-hematopoietic stromal cells. This diverse group of cells supports lymphocyte migration and homing, facilitates antigen delivery, and promotes T cell ...
    • Structure and Function of the Murine Lymph Node 

      Woodruff, Matthew Charles (2014-10-22)
      Lymph nodes (LNs) are dynamic organs responsible for providing a supportive and centralized environment for the generation of immune response. Utilizing a highly organized network of non-hematopoietic stromal cells, the ...
    • Trans-nodal migration of resident dendritic cells into medullary interfollicular regions initiates immunity to influenza vaccine 

      Woodruff, Matthew C.; Heesters, Balthasar A.; Herndon, Caroline N.; Groom, Joanna R.; Thomas, Paul G.; Luster, Andrew D.; Turley, Shannon J.; Carroll, Michael C. (The Rockefeller University Press, 2014)
      Dendritic cells (DCs) are well established as potent antigen-presenting cells critical to adaptive immunity. In vaccination approaches, appropriately stimulating lymph node–resident DCs (LNDCs) is highly relevant to effective ...
    • Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks 

      Malhotra, Deepali; Fletcher, Anne; Astarita, Jillian Leigh; Lukacs-Kornek, Veronika; Tayalia, Prakriti; Gonzalez, Santiago F.; Elpek, Kutlu G.; Chang, Sook Kyung; Knoblich, Konstantin; Hemler, Martin Edward; Brenner, Michael Barry; Carroll, Michael C.; Mooney, David J.; Turley, Shannon J. (Nature Publishing Group, 2012)
      Lymph node stromal cells (LNSCs) closely regulate immunity and self-tolerance, yet key aspects of their biology remain poorly illuminated. Comparative transcriptomic analyses of murine LNSC subsets revealed expression of ...