Browsing by Author "Turka, Laurence"
Now showing items 1-4 of 4
-
Defining a Role for T Regulatory Cell Expressed MyD88 During the Response to Allografts
Borges, Christopher Michael (2015-11-16)The myeloid differentiation primary response gene 88 (MyD88) is an adaptor protein proximally downstream of the Toll-like receptor (TLRs) and the IL-1 receptor family (IL-1R, IL- 18R and IL-33R). The TLR-MyD88 signaling ... -
A Mouse Model of Vitiligo with Focused Epidermal Depigmentation Requires IFN-γ for Autoreactive \(CD8^+\) T Cell Accumulation in the Skin
Harris, Tajie H.; Weninger, Wolfgang; Wherry, E. John; Hunter, Christopher A.; Harris, John E.; Turka, Laurence A (Nature Publishing Group, 2012)Vitiligo is an autoimmune disease of the skin causing disfiguring patchy depigmentation of the epidermis and, less commonly, hair. Therapeutic options for vitiligo are limited, reflecting in part limited knowledge of disease ... -
The phosphatase PTEN-mediated control of PI-3 kinase in Tregs cells maintains homeostasis and lineage stability
Huynh, Alexandria; DuPage, Michel; Priyadharshini, Bhavana; Sage, Peter T.; Quiros, Jason; Borges, Christopher M.; Townamchai, Natavudh; Gerriets, Valerie A.; Rathmell, Jeffrey C.; Sharpe, Arlene H.; Bluestone, Jeffrey A.; Turka, Laurence A. (2014)Foxp3+ regulatory T cells (Tregs) are required for immune homeostasis. One notable distinction between conventional T cells (Tconv) and Tregs is differential phosphatidylinositol 3-kinase (PI3K) activity: only Tconv ... -
Regulation of T Cell Homeostasis and Responses by Pten
Newton, Ryan; Turka, Laurence A. (Frontiers Research Foundation, 2012)The generation of lipid products catalyzed by PI3K is critical for normal T cell homeostasis and a productive immune response. PI3K can be activated in response to antigen receptor, co-stimulatory, cytokine, and chemokine ...