Now showing items 1-5 of 5

    • Cross-Species Array Comparative Genomic Hybridization Identifies Novel Oncogenic Events in Zebrafish and Human Embryonal Rhabdomyosarcoma 

      Chen, Eleanor Y.; Dobrinski, Kimberly P.; Brown, Kim H.; Clagg, Ryan; Edelman, Elena; Ignatius, Myron S.; Chen, Jin Yun Helen; Brockmann, Jillian; Nielsen, G. Petur; Ramaswamy, Sridhar; Keller, Charles; Lee, Charles; Langenau, David M. (Public Library of Science, 2013)
      Human cancer genomes are highly complex, making it challenging to identify specific drivers of cancer growth, progression, and tumor maintenance. To bypass this obstacle, we have applied array comparative genomic hybridization ...
    • High-Throughput Cell Transplantation Establishes That Tumor-Initiating Cells Are Abundant in Zebrafish T-Cell Acute Lymphoblastic Leukemia 

      Smith, Alexandra C. H.; Raimondi, Aubrey R.; Salthouse, Chris D.; Ignatius, Myron S; Blackburn, Jessica S; Mizgirev, Igor V.; Storer, Narie Yoo; de Jong, Jill L. O.; Chen, Aye Tin Maung; Zhou, Yi; Revskoy, Sergei; Zon, Leonard Ira; Langenau, David M. (American Society of Hematology, 2010)
      Self-renewal is a feature of cancer and can be assessed by cell transplantation into immune-compromised or immune-matched animals. However, studies in zebrafish have been severely limited by lack of these reagents. Here, ...
    • Imaging tumour cell heterogeneity following cell transplantation into optically clear immune-deficient zebrafish 

      Tang, Qin; Moore, John C.; Ignatius, Myron S.; Tenente, Inês M.; Hayes, Madeline N.; Garcia, Elaine G.; Torres Yordán, Nora; Bourque, Caitlin; He, Shuning; Blackburn, Jessica S.; Look, A. Thomas; Houvras, Yariv; Langenau, David M. (Nature Publishing Group, 2016)
      Cancers contain a wide diversity of cell types that are defined by differentiation states, genetic mutations and altered epigenetic programmes that impart functional diversity to individual cells. Elevated tumour cell ...
    • Myogenic regulatory transcription factors regulate growth in rhabdomyosarcoma 

      Tenente, Inês M; Hayes, Madeline N; Ignatius, Myron S; McCarthy, Karin; Yohe, Marielle; Sindiri, Sivasish; Gryder, Berkley; Oliveira, Mariana L; Ramakrishnan, Ashwin; Tang, Qin; Chen, Eleanor Y; Petur Nielsen, G; Khan, Javed; Langenau, David M (eLife Sciences Publications, Ltd, 2017)
      Rhabdomyosarcoma (RMS) is a pediatric malignacy of muscle with myogenic regulatory transcription factors MYOD and MYF5 being expressed in this disease. Consensus in the field has been that expression of these factors likely ...
    • Optimized cell transplantation using adult rag2 mutant zebrafish 

      Tang, Qin; Abdelfattah, Nouran S.; Blackburn, Jessica S.; Moore, John C.; Martinez, Sarah A.; Moore, Finola E.; Lobbardi, Riadh; Tenente, Inês M.; Ignatius, Myron S.; Berman, Jason N.; Liwski, Robert S.; Houvras, Yariv; Langenau, David M. (2014)
      Cell transplantation into adult zebrafish has lagged behind mouse due to the lack of immune compromised models. Here, we have created homozygous rag2E450fs mutant zebrafish that have reduced numbers of functional T and B ...