Now showing items 1-8 of 8

    • Angiotensin II Induced Cardiac Dysfunction on a Chip 

      Horton, Renita E.; Yadid, Moran; McCain, Megan L.; Sheehy, Sean P.; Pasqualini, Francesco S.; Park, Sung-Jin; Cho, Alexander; Campbell, Patrick; Parker, Kevin Kit (Public Library of Science, 2016)
      In vitro disease models offer the ability to study specific systemic features in isolation to better understand underlying mechanisms that lead to dysfunction. Here, we present a cardiac dysfunction model using angiotensin ...
    • Coupling primary and stem cell–derived cardiomyocytes in an in vitro model of cardiac cell therapy 

      Aratyn-Schaus, Yvonne; Pasqualini, Francesco S.; Yuan, Hongyan; McCain, Megan L.; Ye, George J.C.; Sheehy, Sean P.; Campbell, Patrick H.; Parker, Kevin Kit (The Rockefeller University Press, 2016)
      The efficacy of cardiac cell therapy depends on the integration of existing and newly formed cardiomyocytes. Here, we developed a minimal in vitro model of this interface by engineering two cell microtissues (μtissues) ...
    • Design Considerations for Engineered Myocardium 

      Sheehy, Sean Paul (2014-06-06)
      The fabrication of biomimetic heart muscle suitable for pharmaceutical compound evaluation and disease modeling is hindered by limitations in our understanding of how to guide and assess the maturity of engineered myocardium ...
    • Hierarchical architecture influences calcium dynamics in engineered cardiac muscle 

      Pong, T.; Adams, William James; Bray, Mark-Anthony; Feinberg, Adam W.; Sheehy, Sean Paul; Werdich, Andreas A.; Parker, Kevin Kit (SAGE Publications, 2011)
      Changes in myocyte cell shape and tissue structure are concurrent with changes in electromechanical function in both the developing and diseased heart. While the anisotropic architecture of cardiac tissue is known to ...
    • Mechanotransduction and Metabolism in Cardiomyocyte Microdomains 

      Pasqualini, Francesco S.; Nesmith, Alexander P.; Horton, Renita E.; Sheehy, Sean P.; Parker, Kevin Kit (Hindawi Publishing Corporation, 2016)
      Efficient contractions of the left ventricle are ensured by the continuous transfer of adenosine triphosphate (ATP) from energy production sites, the mitochondria, to energy utilization sites, such as ionic pumps and the ...
    • Recapitulating maladaptive, multiscale remodeling of failing myocardium on a chip 

      McCain, M. L.; Sheehy, Sean Paul; Grosberg, A.; Goss, J. A.; Parker, Kevin Kit (Proceedings of the National Academy of Sciences, 2013)
      The lack of a robust pipeline of medical therapeutic agents for the treatment of heart disease may be partially attributed to the lack of in vitro models that recapitulate the essential structure–function relationships of ...
    • Self-Organization of Muscle Cell Structure and Function 

      Grosberg, Anna; Kuo, Po-Ling; Guo, Chin-Lin; Geisse, Nicholas A.; Bray, Mark-Anthony; Adams, William J.; Sheehy, Sean Paul; Parker, Kevin Kit (Public Library of Science (PLoS), 2011)
      The organization of muscle is the product of functional adaptation over several length scales spanning from the sarcomere to the muscle bundle. One possible strategy for solving this multiscale coupling problem is to ...
    • The structure-function relationships of a natural nanoscale photonic device in cuttlefish chromatophores 

      Deravi, L. F.; Magyar, Andrew; Sheehy, Sean Paul; Bell, G. R. R.; Mathger, L. M.; Senft, S. L.; Wardill, T. J.; Lane, W. S.; Kuzirian, A. M.; Hanlon, R. T.; Hu, Evelyn; Parker, K. K. (The Royal Society, 2014)
      Cuttlefish, Sepia officinalis, possess neurally controlled, pigmented chromatophore organs that allow rapid changes in skin patterning and coloration in response to visual cues. This process of adaptive coloration is enabled ...