Browsing by Author "Yaffe, Michael"
Now showing items 1-4 of 4
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Development and Application of Lysate Microarray Technology for Quantitative Analysis of Human Disease
Ye, Albert Shanbuo (2013-08-28)Reductionist biology has yielded tremendous insight into the basis of biochemistry and genetic disease. However, the remarkable failure of reductionist biology to explain complex problems, especially cancer, has led to the ... -
Hem-1 Complexes Are Essential for Rac Activation, Actin Polymerization, and Myosin Regulation during Neutrophil Chemotaxis
Weiner, Orion D; Rentel, Maike C; Ott, Alex; Bourne, Henry R; Schliwa, Manfred; Brown, Glenn E.; Jedrychowski, Mark P.; Yaffe, Michael Bruce; Gygi, Steven P.; Cantley, Lewis C.; Kirschner, Marc W. (Public Library of Science, 2006)Migrating cells need to make different actin assemblies at the cell's leading and trailing edges and to maintain physical separation of signals for these assemblies. This asymmetric control of activities represents one ... -
A Mitotic Phosphorylation Feedback Network Connects Cdk1, Plk1, 53BP1, and Chk2 to Inactivate the G2/M DNA Damage Checkpoint
van Vugt, Marcel A. T. M.; Gardino, Alexandra K.; Linding, Rune; Reinhardt, H. Christian; Ong, Shao-En; Tan, Chris S.; Miao, Hua; Keezer, Susan M.; Li, Jeijin; Pawson, Tony; Carr, Steven A.; Smerdon, Stephen J.; Brummelkamp, Thijn R.; Ostheimer, Gerard Joseph; Lewis, Timothy A.; Yaffe, Michael Bruce (Public Library of Science, 2010)DNA damage checkpoints arrest cell cycle progression to facilitate DNA repair. The ability to survive genotoxic insults depends not only on the initiation of cell cycle checkpoints but also on checkpoint maintenance. While ... -
Plk1 Self-Organization and Priming Phosphorylation of HsCYK-4 at the Spindle Midzone Regulate the Onset of Division in Human Cells
Burkard, Mark E.; Maciejowski, John; Rodriguez-Bravo, Verónica; Repka, Michael; Lowery, Drew M.; Clauser, Karl R.; Zhang, Chao; Shokat, Kevan M.; Carr, Steven A.; Jallepalli, Prasad V.; Yaffe, Michael Bruce (Public Library of Science, 2009)Animal cells initiate cytokinesis in parallel with anaphase onset, when an actomyosin ring assembles and constricts through localized activation of the small GTPase RhoA, giving rise to a cleavage furrow. Furrow formation ...