Browsing by Author "Gifford, David Kenneth"
Now showing items 1-4 of 4
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Automated Discovery of Functional Generality of Human Gene Expression Programs
Gerber, Georg Kurt; Dowell, Robin D; Jaakkola, Tommi S; Gifford, David Kenneth (Public Library of Science, 2007)An important research problem in computational biology is the identification of expression programs, sets of co-expressed genes orchestrating normal or pathological processes, and the characterization of the functional ... -
Detection of Delirium in the Intensive Care Unit: Comparison of Confusion Assessment Method for the Intensive Care Unit with Confusion Assessment Method Ratings
Gifford, David Kenneth; Inouye, Sharon; McNicoll, Lynn; Pisani, Margaret; Ely, E. Wesley (Wiley-Blackwell, 2005)Objectives: To compare the Confusion Assessment Method (CAM) and CAM for the Intensive Care Unit (CAM-ICU) methods for detecting delirium in alert, nonintubated older ICU patients. Design: Comparison study. Setting: ... -
Lineage-Based Identification of Cellular States and Expression Programs
Hashimoto, Tatsunori Benjamin; Jaakkola, Tommi; Sherwood, Richard Irving; Mazzoni, Esteban O.; Wichterle, Hynek; Gifford, David Kenneth (Oxford University Press, 2012)Summary: We present a method, LineageProgram, that uses the developmental lineage relationship of observed gene expression measurements to improve the learning of developmentally relevant cellular states and expression ... -
Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells
Li, Weida; Cavelti-Weder, Claudia; Zhang, Yinying; Clement, Kendell; Donovan, Scott; Gonzalez, Gabriel; Zhu, Jiang; Stemann, Marianne; Xu, Ke; Hashimoto, Tatsu; Yamada, Takatsugu; Nakanishi, Mio; Zhang, Yuemei; Zeng, Samuel; Gifford, David Kenneth; Meissner, Alexander; Weir, Gordon Campbell; Zhou, Qiao (Nature Publishing Group, 2014)Direct lineage conversion is a promising approach to generate therapeutically important cell types for disease modeling and tissue repair. However, the survival and function of lineage-reprogrammed cells in vivo over the ...