Browsing by Author "Loison, Fabien"
Now showing items 1-14 of 14
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Constitutive Neutrophil Apoptosis: Mechanisms and Regulation
Luo, Hongbo; Loison, Fabien (Wiley-Blackwell, 2008)Neutrophil constitutive death is a critical cellular process for modulating neutrophil number and function, and it plays an essential role in neutrophil homeostasis and the resolution of inflammation. Neutrophils die due ... -
Deactivation of Akt by a Small Molecule Inhibitor Targeting Pleckstrin Homology Domain and Facilitating Akt Ubiquitination
Jo, Hakryul; Lo, Pang-Kuo; Li, Yitang; Loison, Fabien; Green, Sarah; Wang, Jake; Silberstein, Leslie E.; Ye, Keqiang; Chen, Hexin; Luo, Hongbo (Proceedings of the National Academy of Sciences, 2011)The phosphatidylinositol-3,4,5-triphosphate (PIP3) binding function of pleckstrin homology (PH) domain is essential for the activation of oncogenic Akt/PKB kinase. Following the PIP3-mediated activation at the membrane, ... -
Focal Adhesion Kinase Regulates Pathogen-Killing Capability and Life Span of Neutrophils via Mediating both Adhesion-Dependent and -Independent Cellular Signals
Kasorn, Anongnard; Alcaide, Pilar; Jia, Yonghui; Subramanian, Kulandayan K.; Sarraj, Bara; Li, Yitang; Loison, Fabien; Hattori, Hidenori; Silberstein, Leslie E.; Luscinskas, William F.; Luo, Hongbo (American Association of Immunologists, 2009)Various neutrophil functions such as phagocytosis, superoxide production, and survival are regulated by integrin signaling. Despite the essential role of focal adhesion kinase (FAK) in mediating this signaling pathway, its ... -
Inositol Hexakisphosphate Kinase 1 Regulates Neutrophil Function in Innate Immunity by Inhibiting Phosphatidylinositol-(3,4,5)-Trisphosphate Signaling
Prasad, Amit; Jia, Yonghui; Chakraborty, Anutosh; Li, Yitang; Jain, Supriya K.; Zhong, Jia; Roy, Saurabh Ghosh; Loison, Fabien; Mondal, Subhanjan; Sakai, Jiro; Blanchard, Catlyn; Snyder, Solomon H.; Luo, Hongbo (Nature Publishing Group, 2011)Inositol phosphates are widely produced throughout animal and plant tissues. Diphosphoinositol pentakisphosphate (InsP7) contains an energetic pyrophosphate bond. Here we demonstrate that disruption of inositol hexakisphosphate ... -
Inositol Trisphosphate 3-Kinase B (InsP3KB) as a Physiological Modulator of Myelopoiesis
Jia, Yonghui; Loison, Fabien; Hattori, Hidenori; Li, Yitang; Erneux, Christophe; Park, Shin-Young; Gao, Chong; Chai, Li; Silberstein, Leslie E.; Schurmans, Stephane; Luo, Hongbo (Proceedings of the National Academy of Sciences, 2008)Inositol trisphosphate 3-kinase B (InsP3KB) belongs to a family of kinases that convert inositol 1,4,5-trisphosphate (Ins(1,4,5)P3 or IP3) to inositol 1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4). Previous studies have shown ... -
Microtubule Dynamics Regulates Akt Signaling via Dynactin p150
Jo, Hakryul; Loison, Fabien; Luo, Hongbo (Elsevier BV, 2014)Following activation at the plasma membrane, Akt is subsequently deactivated in the cytoplasm. Although activation and deactivation of Akt must sometimes be separated in order to elicit and control cellular responses, the ... -
Myeloid-Specific Deletion of Tumor Suppressor PTEN Augments Neutrophil Transendothelial Migration during Inflammation
Sarraj, Bara; Massberg, Steffen; Li, Yitang; Kasorn, Anongnard; Subramanian, Kulandayan; Loison, Fabien; Silberstein, Leslie E.; von Andrian, Ulrich H.; Luo, Hongbo (American Association of Immunologists, 2014-11-04)Phosphatidylinositol 3,4,5-trisphosphate \((PIP_3)\) is a second messenger that is involved in a number of cell activities including cell growth, proliferation, and motility. \(PIP_3\) is produced by PI3K and regulated by ... -
Natural Product Celastrol Destabilizes Tubulin Heterodimer and Facilitates Mitotic Cell Death Triggered by Microtubule-Targeting Anti-Cancer Drugs
Jo, Hakryul; Loison, Fabien Xavier; Hattori, Hidenori; Silberstein, Leslie E.; Yu, Hongtao; Luo, Hongbo (Public Library of Science, 2010)Background: Microtubule drugs are effective anti-cancer agents, primarily due to their ability to induce mitotic arrest and subsequent cell death. However, some cancer cells are intrinsically resistant or acquire a resistance. ... -
Neutrophil Apoptosis and Its Involvement in Inflammation and Infection
Loison, Fabien; Luo, Hongbo (CRC Press, 2010)Neutrophil accumulation at inflammatory sites is an important component of innate immunity and is required for the host’s ability to kill invading pathogens. However, exaggerated neutrophil accumulation can also lead to ... -
Neutrophil Spontaneous Death Is Mediated by Down-Regulation of Autocrine Signaling through GPCR, PI3K\(\gamma\), ROS, and actin
Xu, Yuanfu; Loison, Fabien; Luo, Hongbo (Proceedings of the National Academy of Sciences, 2010)Neutrophil spontaneous apoptosis plays a crucial role in neutrophil homeostasis and the resolution of inflammation. We previously established Akt deactivation as a key mediator of this tightly regulated cellular death ... -
Pretreatment with Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN) Inhibitor SF1670 Augments the Efficacy of Granulocyte Transfusion in a Clinically Relevant Mouse Model
Li, Yitang; Prasad, Amit; Jia, Yonghui; Roy, Saurabh Ghosh; Loison, Fabien; Mondal, Subhanjan; Kocjan, Paulina; Silberstein, Leslie E.; Ding, Sheng; Luo, Hongbo (American Society of Hematology, 2011)The clinical outcome of granulocyte transfusion therapy is often hampered by short ex vivo shelf life, inefficiency of recruitment to sites of inflammation, and poor pathogen-killing capability of transplanted neutrophils. ... -
PTEN Negatively Regulates Engulfment of Apoptotic Cells by Modulating Activation of Rac GTPase
Mondal, Subhanjan; Ghosh-Roy, Saurabh; Loison, Fabien; Li, Yitang; Jia, Yonghui; Harris, Chad; Williams, David Allan; Luo, Hongbo (American Association of Immunologists, 2011)Efficient clearance of apoptotic cells by phagocytes (efferocytosis) is critical for normal tissue homeostasis and regulation of the immune system. Apoptotic cells are recognized by a vast repertoire of receptors on ... -
Small-Molecule Screen Identifies Reactive Oxygen Species as Key Regulators of Neutrophil Chemotaxis
Hattori, Hidenori; Subramanian, Kulandayan K.; Sakai, Jiro; Jia, Yonghui; Li, Yitang; Porter, Timothy F.; Loison, Fabien; Sarraj, Bara; Kasorn, Anongnard; Jo, Hakryul; Blanchard, Catlyn; Zirkle, Dorothy; McDonald, Douglas Ray; Pai, Sung-Yun; Serhan, Charles Nicholas; Luo, Hongbo (Proceedings of the National Academy of Sciences, 2010)Neutrophil chemotaxis plays an essential role in innate immunity, but the underlying cellular mechanism is still not fully characterized. Here, using a small-molecule functional screening, we identified NADPH oxidase–dependent ... -
Targeted Deletion of Tumor Suppressor PTEN Augments Neutrophil Function and Enhances Host Defense in Neutropenia-Associated Pneumonia
Li, Yitang; Jia, Yonghui; Pichavant, Muriel; Loison, Fabien; Sarraj, Bara; Kasorn, Anongnard; You, Jian; Robson, Bryanne E.; Umetsu, Dale; Mizgerd, Joseph P.; Ye, Keqiang; Luo, Hongbo (American Society of Hematology, 2009)Neutropenia and related infections are the most important dose-limiting toxicities in anticancer chemotherapy and radiotherapy. In this study, we explored a new strategy for augmenting host defense in neutropenia-related ...