Now showing items 1-7 of 7

    • Alterations in brain structures underlying language function in young adults at high familial risk for schizophrenia 

      Francis, Alan N; Seidman, Larry Joel; Jabbar, Gul A.; Mesholam-Gately, Raquelle; Thermenos, Heidi Wencel; Juelich, Richard; Proal, Ashley; Shenton, Martha Elizabeth; Kubicki, Marek R.; Mathew, Ian; Keshavan, Matcheri S; DeLisi, Lynn E (Elsevier BV, 2012)
      Introduction—Neuroanatomical and cognitive alterations typical of schizophrenia (SZ) patients are observed to a lesser extent in their adolescent and adult first-degree relatives, likely reflecting neurodevelopmental ...
    • Altered language network activity in young people at familial high-risk for schizophrenia 

      Thermenos, Heidi Wencel; Whitfield-Gabrieli, S.; Seidman, Larry Joel; Kuperberg, Gina Rosalind; Juelich, R.J.; Divatia, S.; Riley, C.; Jabbar, G.A.; Shenton, Martha Elizabeth; Kubicki, Marek R.; Manschreck, Theo Clyde; Keshavan, Matcheri S; DeLisi, Lynn E (Elsevier BV, 2013)
      Background—Abnormalities in language and language neural circuitry are observed in schizophrenia (SZ). Similar, but less pronounced language deficits are also seen in young first degree relatives of people with SZ, who ...
    • Correlates to the variable effects of cannabis in young adults: a preliminary study 

      Camera, Ariella Anne; Tomaselli, Veronica; Fleming, Jerry; Jabbar, Gul A; Trachtenberg, Melissa; Galvez-Buccollini, Juan A; Proal, Ashley; Rosenthal, Richard N; DeLisi, Lynn E (BioMed Central, 2012)
      Background: Cannabis use can frequently have adverse affects in those that use it and these can be amplified by various characteristics of an individual, from demographic and environmental variations to familial predisposition ...
    • Decreased axial diffusivity within language connections: A possible biomarker of schizophrenia risk 

      Kubicki, Marek R.; Shenton, Martha Elizabeth; Maciejewski, P; Pelavin, P.E.; Hawley, K.J.; Ballinger, T.; Swisher, T.; Jabbar, G.A.; Thermenos, Heidi Wencel; Keshavan, Matcheri S; Seidman, Larry Joel; DeLisi, Lynn E (Elsevier BV, 2013)
      Siblings of patients diagnosed with schizophrenia are at elevated risk for developing this disorder. The nature of such risk associated with brain abnormalities, and whether such abnormalities are similar to those observed ...
    • A novel analytical framework for dissecting the genetic architecture of behavioral symptoms in neuropsychiatric disorders 

      Deo, Anthony J.; Costa, Ramiro; DeLisi, Lynn E; DeSalle, Rob; Haghighi, Fatemeh (Public Library of Science, 2010)
      Background: For diagnosis of neuropsychiatric disorders, a categorical classification system is often utilized as a simple way for conceptualizing an often complex clinical picture. This approach provides an unsatisfactory ...
    • Quantitative Trait Locus and Brain Expression of HLA-DPA1 Offers Evidence of Shared Immune Alterations in Psychiatric Disorders 

      Morgan, Ling Z.; Rollins, Brandi; Sequeira, Adolfo; Byerley, William; DeLisi, Lynn E.; Schatzberg, Alan F.; Barchas, Jack D.; Myers, Richard M.; Watson, Stanley J.; Akil, Huda; Bunney, William E.; Vawter, Marquis P. (2016)
      Genome-wide association studies of schizophrenia encompassing the major histocompatibility locus (MHC) were highly significant following genome-wide correction. This broad region implicates many genes including the MHC ...
    • Rare Mutations in N-methyl-D-aspartate Glutamate Receptors in Autism Spectrum Disorders and Schizophrenia 

      Tarabeux, J; Kebir, O; Hamdan, F F; Piton, A; Henrion, É; Millet, B; Fathalli, F; Joober, R; Rapoport, J L; Fombonne, É; Mottron, L; Forget-Dubois, N; Boivin, M; Michaud, J L; Drapeau, P; Lafrenière, R G; Rouleau, G A; Krebs, M-O; Gauthier, J.; DeLisi, Lynn E; Xiong, L.; Spiegelman, D. (Nature Publishing Group, 2011)
      Pharmacological, genetic and expression studies implicate N-methyl-D-aspartate (NMDA) receptor hypofunction in schizophrenia (SCZ). Similarly, several lines of evidence suggest that autism spectrum disorders (ASD) could ...