Now showing items 1-3 of 3

    • Activation of TRPC6 Channels Is Essential for Lung Ischaemia–Reperfusion Induced Oedema in Mice 

      Weissmann, Norbert; Sydykov, Akylbek; Storch, Ursula; Fuchs, Beate; Schnitzler, Michael Mederos y; Brandes, Ralf P.; Grimminger, Friedrich; Meissner, Marcel; Freichel, Marc; Offermanns, Stefan; Veit, Florian; Pak, Oleg; Krause, Karl-Heinz; Schermuly, Ralph T.; Brewer, Alison C; Schmidt, Harald H.H.W.; Seeger, Werner; Gudermann, Thomas; Ghofrani, Hossein A.; Dietrich, Alexander; Kalwa, Hermann H; Shah, Ajay Mukesh (Nature Publishing Group, 2012)
      Lung ischaemia–reperfusion-induced oedema (LIRE) is a life-threatening condition that causes pulmonary oedema induced by endothelial dysfunction. Here we show that lungs from mice lacking nicotinamide adenine dinucleotide ...
    • Caveolin-1 Is a Critical Determinant of Autophagy, Metabolic Switching, and Oxidative Stress in Vascular Endothelium 

      Shiroto, Takashi; Romero, Natalia; Sugiyama, Toru; Sartoretto, Juliano L.; Kalwa, Hermann; Yan, Zhonghua; Shimokawa, Hiroaki; Michel, Thomas (Public Library of Science, 2014)
      Caveolin-1 is a scaffolding/regulatory protein that interacts with diverse signaling molecules. Caveolin-1null mice have marked metabolic abnormalities, yet the underlying molecular mechanisms are incompletely understood. ...
    • Role of Ca\(^{2+}\) in the Control of H\(_2\)O\(_2\)-Modulated Phosphorylation Pathways Leading to eNOS Activation in Cardiac Myocytes 

      Shiroto, Takashi; Sartoretto, Simone M.; Pluth, Michael D.; Lippard, Stephen J.; Sartoretto, Juliano Luiz; Kalwa, Hermann H; Michel, Thomas Mark (Public Library of Science, 2012)
      Nitric oxide (NO) and hydrogen peroxide (H\(_2\)O\(_2\)) play key roles in physiological and pathological responses in cardiac myocytes. The mechanisms whereby H\(_2\)O\(_2\)–modulated phosphorylation pathways regulate the ...