Browsing by Author "ElKhal, Abdallah"

Now showing items 1-4 of 4

    • Autonomous Vascular Networks Synchronize GABA Neuron Migration in the Embryonic Forebrain 

      Won, Chungkil; Lin, Zhicheng; Kumar T, Peeyush; Li, Suyan; Ding, Lai; Elkhal, Abdallah; Szabó, Gábor; Vasudevan, Anju (2013)
      GABA neurons, born in remote germinative zones in the ventral forebrain (telencephalon), migrate tangentially in two spatially distinct streams to adopt their specific positions in the developing cortex. The cell types and ...

    • NAD+ Mediated Rescue of Prenatal Forebrain Angiogenesis Restores Postnatal Behavior 

      Subburaju, Sivan; Kaye, Sarah; Choi, Yong Kee; Baruah, Jugajyoti; Datta, Debkanya; Ren, Jun; Kumar, Ashwin Srinivasan; Szabo, Gabor; Fukumura, Dai; Jain, Rakesh; ElKhal, Abdallah; Vasudevan, Anju (American Association for the Advancement of Science (AAAS), 2020-10-09)
      Intrinsic defects within blood vessels from the earliest developmental time points can directly contribute to psychiatric disease origin. Our work has shown that pre-formed vascular networks autonomously regulate key events ...

    • NAD+ protects against EAE by regulating CD4+ T-cell differentiation 

      Tullius, Stefan G.; Biefer, Hector Rodriguez Cetina; Li, Suyan; Trachtenberg, Alexander J.; Edtinger, Karoline; Quante, Markus; Krenzien, Felix; Uehara, Hirofumi; Yang, Xiaoyong; Kissick, Haydn T.; Kuo, Winston P.; Ghiran, Ionita; de la Fuente, Miguel A.; Arredouani, Mohamed S.; Camacho, Virginia; Tigges, John C.; Toxavidis, Vasilis; El Fatimy, Rachid; Smith, Brian D.; Vasudevan, Anju; ElKhal, Abdallah (Nature Pub. Group, 2014)
      CD4+ T cells are involved in the development of autoimmunity, including multiple sclerosis (MS). Here we show that nicotinamide adenine dinucleotide (NAD+) blocks experimental autoimmune encephalomyelitis (EAE), a mouse ...

    • NAD+ regulates Treg cell fate and promotes allograft survival via a systemic IL-10 production that is CD4+ CD25+ Foxp3+ T cells independent 

      Elkhal, Abdallah; Rodriguez Cetina Biefer, Hector; Heinbokel, Timm; Uehara, Hirofumi; Quante, Markus; Seyda, Midas; Schuitenmaker, Jeroen M.; Krenzien, Felix; Camacho, Virginia; de la Fuente, Miguel A.; Ghiran, Ionita; Tullius, Stefan G. (Nature Publishing Group, 2016)
      CD4+ CD25+ Foxp3+ Tregs have been shown to play a central role in immune homeostasis while preventing from fatal inflammatory responses, while Th17 cells have traditionally been recognized as pro-inflammatory mediators ...