Now showing items 1-16 of 16

    • Blood Accessibility to Fibrin in Venous Thrombosis is Thrombus Age-Dependent and Predicts Fibrinolytic Efficacy: An In Vivo Fibrin Molecular Imaging Study 

      Stein-Merlob, Ashley F.; Kessinger, Chase W.; Erdem, S. Sibel; Zelada, Henry; Hilderbrand, Scott A.; Lin, Charles P.; Tearney, Guillermo J.; Jaff, Michael R.; Reed, Guy L.; Henke, Peter K.; McCarthy, Jason R.; Jaffer, Farouc A. (Ivyspring International Publisher, 2015)
      Fibrinolytic therapy of venous thromboembolism (VTE) is increasingly utilized, yet limited knowledge is available regarding in vivo mechanisms that govern fibrinolytic efficacy. In particular, it is unknown how age-dependent ...
    • Characterization of Defects in Ion Transport and Tissue Development in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)-Knockout Rats 

      Tuggle, Katherine L.; Birket, Susan E.; Cui, Xiaoxia; Hong, Jeong; Warren, Joe; Reid, Lara; Chambers, Andre; Ji, Diana; Gamber, Kevin; Chu, Kengyeh K.; Tearney, Guillermo; Tang, Li Ping; Fortenberry, James A.; Du, Ming; Cadillac, Joan M.; Bedwell, David M.; Rowe, Steven M.; Sorscher, Eric J.; Fanucchi, Michelle V. (Public Library of Science, 2014)
      Animal models for cystic fibrosis (CF) have contributed significantly to our understanding of disease pathogenesis. Here we describe development and characterization of the first cystic fibrosis rat, in which the cystic ...
    • Co-Registered Spectrally Encoded Confocal Microscopy and Optical Frequency Domain Imaging System 

      Kang, D.K.; Suter, Melissa; Boudoux, Caroline; Yachimski, P.S.; Puricelli, W.P.; Nishioka, Norman Shizuaki; Mino-Kenudson, Mari; Lauwers, Gregory Y.; Bouma, Brett; Tearney, Guillermo James (Wiley-Blackwell, 2010)
      Spectrally encoded confocal microscopy and optical frequency domain imaging are two non-contact optical imaging technologies that provide images of tissue cellular and architectural morphology, which are both used for ...
    • Comprehensive confocal endomicroscopy of the esophagus in vivo 

      Kang, Dongkyun; Schlachter, Simon C.; Carruth, Robert W.; Kim, Minkyu; Wu, Tao; Tabatabaei, Nima; Vacas-Jacques, Paulino; Shishkov, Milen; Woods, Kevin; Sauk, Jenny S.; Leung, John; Nishioka, Norman S.; Tearney, Guillermo J. (© Georg Thieme Verlag KG, 2014)
      Background and study aims: Biopsy sampling error can be a problem for the diagnosis of certain gastrointestinal tract diseases. Spectrally-encoded confocal microscopy (SECM) is a high-speed reflectance confocal microscopy ...
    • Comprehensive Imaging of Gastroesophageal Biopsy Samples by Spectrally Encoded Confocal Microscopy 

      Kang, DongKyun; Suter, Melissa; Boudoux, Caroline; Yoo, Hongki; Yachimski, Patrick S.; Puricelli, William P.; Nishioka, Norman Shizuaki; Mino-Kenudson, Mari; Lauwers, Gregory Y.; Bouma, Brett; Tearney, Guillermo James (Elsevier BV, 2010)
      Background: Spectrally encoded confocal microscopy (SECM) is a high-speed reflectance confocal microscopy technique that has the potential to be used for acquiring comprehensive images of the entire distal esophagus ...
    • Comprehensive Microscopy of the Esophagus in Human Patients with Optical Frequency Domain Imaging 

      Suter, Melissa; Vakoc, Benjamin; Yachimski, Patrick S.; Shishkov, Milen Stefanov; Lauwers, Gregory Y.; Mino-Kenudson, Mari; Bouma, Brett; Nishioka, Norman Shizuaki; Tearney, Guillermo James (Elsevier BV, 2008)
      Background: Optical coherence tomography (OCT) is a cross-sectional, high-resolution imaging modality that has been shown to accurately differentiate esophageal specialized intestinal metaplasia (SIM) from gastric cardia ...
    • Comprehensive Volumetric Confocal Microscopy with Adaptive Focusing 

      Kang, DongKyun; Yoo, Hongki; Jillella, Priyanka; Bouma, Brett; Tearney, Guillermo James (Optical Society of America, 2011)
      Comprehensive microscopy of distal esophagus could greatly improve the screening and surveillance of esophageal diseases such as Barrett’s esophagus by providing histomorphologic information over the entire region at risk. ...
    • Dual-Modality Fluorescence and Full-Field Optical Coherence Microscopy for Biomedical Imaging Applications 

      Auksorius, Egidijus; Bromberg, Yaron; Motiejūnaitė, Rūta; Pieretti, Alberto Christian; Liu, Linbo; Coron, Emmanuel; Aranda, Jorge; Goldstein, Allan Moises; Bouma, Brett; Kazlauskas, Andrius; Tearney, Guillermo James (Optical Society of America, 2012)
      Full-field optical coherence microscopy (FFOCM) is a high-resolution interferometric technique that is particularly attractive for biomedical imaging. Here we show that combining it with structured illumination fluorescence ...
    • Feasibility of the Assessment of Cholesterol Crystals in Human Macrophages Using Micro Optical Coherence Tomography 

      Kashiwagi, Manabu; Liu, Linbo; Chu, Kengyeh K.; Sun, Chen-Hsin; Tanaka, Atsushi; Gardecki, Joseph A.; Tearney, Guillermo J. (Public Library of Science, 2014)
      The presence of cholesterol crystals is a hallmark of atherosclerosis, but until recently, such crystals have been considered to be passive components of necrotic plaque cores. Recent studies have demonstrated that ...
    • Identifying Intestinal Metaplasia at the Squamocolumnar Junction by Using Optical Coherence Tomography 

      Evans, John A.; Bouma, Brett; Bressner, Jason; Shishkov, Milen Stefanov; Lauwers, Gregory Y.; Mino-Kenudson, Mari; Nishioka, Norman Shizuaki; Tearney, Guillermo James (Elsevier BV, 2007)
      Background: Optical coherence tomography (OCT) is an optical imaging method that produces high-resolution cross-sectional images of the esophagus. The accuracy of OCT for differentiating tissue types at the squamocolumnar ...
    • Image-Guided Biopsy in the Esophagus through Comprehensive Optical Frequency Domain Imaging and Laser Marking: A Study in Living Swine 

      Suter, Melissa; Jillella, Priyanka A.; Vakoc, Benjamin; Halpern, Elkan F.; Mino-Kenudson, Mari; Lauwers, Gregory Y.; Bouma, Brett; Nishioka, Norman Shizuaki; Tearney, Guillermo James (Elsevier BV, 2010)
      Background: Random biopsy esophageal surveillance can be subject to sampling errors, resulting in diagnostic uncertainty. Optical frequency domain imaging (OFDI) is a high-speed, 3-dimensional endoscopic microscopy technique. ...
    • Micro-optical coherence tomography of the mammalian cochlea 

      Iyer, Janani S.; Batts, Shelley A.; Chu, Kengyeh K.; Sahin, Mehmet I.; Leung, Hui Min; Tearney, Guillermo J.; Stankovic, Konstantina M. (Nature Publishing Group, 2016)
      The mammalian cochlea has historically resisted attempts at high-resolution, non-invasive imaging due to its small size, complex three-dimensional structure, and embedded location within the temporal bone. As a result, ...
    • Miniature grating for spectrally-encoded endoscopy 

      Kang, DongKyun; Martinez, Ramses V.; Whitesides, George McClelland; Tearney, Guillermo James (Royal Society of Chemistry (RSC), 2013)
      Spectrally-encoded endoscopy (SEE) is an ultraminiature endoscopy technology that acquires high-definition images of internal organs through a sub-mm endoscopic probe. In SEE, a grating at the tip of the imaging optics ...
    • Reflectance Confocal Microscopy for the Diagnosis of Eosinophilic Esophagitis: a Pilot Study Conducted on Biopsy Specimens 

      Yoo, Hongki; Kang, DongKyun; Katz, Aubrey J.; Lauwers, Gregory Y.; Nishioka, Norman Shizuaki; Yagi, Yukako; Tanpowpong, Pornthep; Namati, Jacqueline; Bouma, Brett; Tearney, Guillermo James (Elsevier BV, 2011)
      Background: Diagnosis of eosinophilic esophagitis (EoE) currently requires endoscopic biopsy and histopathologic analysis of the biopsy specimens to count intraepithelial eosinophils. Reflectance confocal microscopy (RCM) ...
    • Tethered capsule endomicroscopy enables less-invasive imaging of gastrointestinal tract microstructure 

      Gora, Michalina J.; Sauk, Jenny S.; Carruth, Robert W.; Gallagher, Kevin A.; Suter, Melissa J.; Nishioka, Norman S.; Kava, Lauren E.; Rosenberg, Mireille; Bouma, Brett E.; Tearney, Guillermo J. (2012)
      Here, we introduce “tethered capsule endomicroscopy,” that involves swallowing an optomechanically-engineered pill that captures cross-sectional, 30 μm (lateral) × 7 μm (axial) resolution, microscopic images of the gut ...
    • Wavefront image sensor chip 

      Cui, Xiquan; Ren, Jian; Tearney, Guillermo James; Yang, Changhuei (Optical Society of America, 2010)
      We report the implementation of an image sensor chip, termed wavefront image sensor chip (WIS), that can measure both intensity/amplitude and phase front variations of a light wave separately and quantitatively. By monitoring ...