Now showing items 1-4 of 4

    • High-Risk Human Papillomavirus E7 Proteins Target PTPN14 for Degradation 

      White, Elizabeth A.; Münger, Karl; Howley, Peter M. (American Society for Microbiology, 2016)
      ABSTRACT The major transformation activity of the high-risk human papillomaviruses (HPV) is associated with the E7 oncoprotein. The interaction of HPV E7 with retinoblastoma family proteins is important for several E7 ...
    • A Human Cytomegalovirus-Encoded microRNA Regulates Expression of Multiple Viral Genes Involved in Replication 

      Grey, Finn; Meyers, Heather; White, Elizabeth; Spector, Deborah H; Nelson, Jay (Public Library of Science, 2007)
      Although multiple studies have documented the expression of over 70 novel virus-encoded microRNAs (miRNAs), the targets and functions of most of these regulatory RNA species are unknown. In this study a comparative ...
    • Human Papillomavirus E6 Triggers Upregulation of the Antiviral and Cancer Genomic DNA Deaminase APOBEC3B 

      Vieira, Valdimara C.; Leonard, Brandon; White, Elizabeth A.; Starrett, Gabriel J.; Temiz, Nuri A.; Lorenz, Laurel D.; Lee, Denis; Soares, Marcelo A.; Lambert, Paul F.; Howley, Peter M.; Harris, Reuben S. (American Society of Microbiology, 2014)
      ABSTRACT Several recent studies have converged upon the innate immune DNA cytosine deaminase APOBEC3B (A3B) as a significant source of genomic uracil lesions and mutagenesis in multiple human cancers, including those of ...
    • Identification of a Signature Motif in Target mRNAs of RNA-binding Protein AUF1 

      Mazan-Mamczarz, Krystyna; Kuwano, Yuki; Zhan, Ming; White, Elizabeth; Martindale, Jennifer; Lal, Ashish; Gorospe, Myriam (Oxford University Press, 2009)
      The ubiquitous RNA-binding protein AUF1 promotes the degradation of some target mRNAs, but increases the stability and translation of other targets. Here, we isolated AUF1-associated mRNAs by immunoprecipitation of (AUF1–RNA) ...