Browsing by Author "Kaufmann, Daniel E."
Now showing items 1-11 of 11
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Elite control of HIV infection: implications for vaccines
Miura, Toshiyuki; Rathod, Almas; Baker, Brett; Trocha, Alicja; Ueda, Peggy; Stone, David; Wrin, Terri; Buchbinder, Susan; Petropoulos, Christos J; Pereyra, Florencia M.; Addo, Marylyn Martina; Kaufmann, Daniel; Rosenberg, Rachel; Cohen, Daniel Aaron; Liu, Yang; Rosenberg, Eric Scott; Walker, Bruce David (BioMed Central, 2006) -
Follicular Dendritic Cells Retain Infectious HIV in Cycling Endosomes
Heesters, Balthasar A.; Lindqvist, Madelene; Vagefi, Parsia A.; Scully, Eileen P.; Schildberg, Frank A.; Altfeld, Marcus; Walker, Bruce D.; Kaufmann, Daniel E.; Carroll, Michael C. (Public Library of Science, 2015)Despite the success of antiretroviral therapy (ART), it does not cure Human Immunodeficiency Virus (HIV) and discontinuation results in viral rebound. Follicular dendritic cells (FDC) are in direct contact with CD4+ T cells ... -
A High-Dimensional Immune Monitoring Model of HIV-1-Specific CD8 T Cell Responses Accurately Identifies Subjects Achieving Spontaneous Viral Control
Proudfoot, J; Vine, S; Cesa, K; Piechocka-Trocha, A; Ndhlovu, Zaza Mtine; Chibnik, Lori; McMullen, A; Porichis, Filippos; Alvino, Donna Marie Lucia; De Jager, Philip Lawrence; Walker, Bruce David; Kaufmann, Daniel (BioMed Central, 2012) -
Immunization of HIV-1-Infected Persons With Autologous Dendritic Cells Transfected With mRNA Encoding HIV-1 Gag and Nef: Results of a Randomized, Placebo-Controlled Clinical Trial
Gandhi, Rajesh T.; Kwon, Douglas S.; Macklin, Eric A.; Shopis, Janet R.; McLean, Anna P.; McBrine, Nicole; Flynn, Theresa; Peter, Lauren; Sbrolla, Amy; Kaufmann, Daniel E.; Porichis, Filippos; Walker, Bruce D.; Bhardwaj, Nina; Barouch, Dan H.; Kavanagh, Daniel G. (JAIDS Journal of Acquired Immune Deficiency Syndromes, 2015)Background: HIV-1 eradication may require reactivation of latent virus along with stimulation of HIV-1-specific immune responses to clear infected cells. Immunization with autologous dendritic cells (DCs) transfected with ... -
Immunodominant HIV-1 Cd4+ T Cell Epitopes in Chronic Untreated Clade C HIV-1 Infection
Ramduth, Danni; Day, Cheryl L.; Thobakgale, Christina F.; Mkhwanazi, Nompumelelo P.; de Pierres, Chantal; Reddy, Sharon; van der Stok, Mary; Mncube, Zenele; Nair, Kriebashne; Moodley, Eshia S.; Coovadia, Hoosen M.; Kiepiela, Photini; Kaufmann, Daniel; Streeck, Hendrik; Goulder, Philip J.; Walker, Bruce David (Public Library of Science, 2009)Background: A dominance of Gag-specific CD8+ T cell responses is significantly associated with a lower viral load in individuals with chronic, untreated clade C human immunodeficiency virus type 1 (HIV-1) infection. This ... -
Impaired hepatitis C virus-specific T cell responses and recurrent hepatitis C virus in HIV coinfection
Kim, Arthur Yu-Shin; Schulze zur Wiesch, Julian; Kuntzen, Thomas; Timm, Joerg; Kaufmann, Daniel; Duncan, Jared E.; Jones, Andrea M.; Wurcel, Alysse G.; Davis, Benjamin Thomas; Gandhi, Rajesh Tim; Robbins, Gregory Kimball; Allen, Todd; Chung, Raymond Taeyong; Lauer, Georg; Walker, Bruce David (Public Library of Science, 2006)Background: Hepatitis C virus (HCV)-specific T cell responses are critical for spontaneous resolution of HCV viremia. Here we examined the effect of a lymphotropic virus, HIV-1, on the ability of coinfected patients to ... -
In Vitro Priming Recapitulates In Vivo HIV-1 Specific T Cell Responses, Revealing Rapid Loss of Virus Reactive CD4+ T Cells in Acute HIV-1 Infection
Lubong Sabado, Rachel; Kavanagh, Daniel Garrett; Kaufmann, Daniel; Fru, Karlhans; Babcock, Ethan; Rosenberg, Eric Scott; Walker, Bruce David; Lifson, Jeffrey; Bhardwaj, Nina; Larsson, Marie (Public Library of Science, 2009)Background: The requirements for priming of HIV-specific T cell responses initially seen in infected individuals remain to be defined. Activation of T cell responses in lymph nodes requires cell-cell contact between T cells ... -
OA031-04. Impairment of HIV-1-specific CD8+ T cell function by soluble epithelial adhesion molecules
Trocha, K; Chevalier, M; Caron, T; Pyo, A; Toth, I; Rodig, SJ; Streeck, Hendrik; Kwon, Douglas; Jolin, Julie Ann; Law, Kayee; Kaufmann, Daniel; Walker, Bruce David; Altfeld, Marcus (BioMed Central, 2009) -
P16-08. Combined blockade of the PD-1 and IL-10 pathways synergistically enhance HIV-specific CD4 T cell functions
Porichis, Filippos; Kwon, DS; Tighe, DP; Pavlik, DF; Kavanagh, Daniel Garrett; Freeman, Gordon James; Walker, Bruce David; Kaufmann, Daniel (BioMed Central, 2009) -
PD-1, IL-10, IFN-γ and IL-12 Form a Network to Regulate HIV-1-Specific CD4 T Cell and Antigen-Presenting Cell Function
Porichis, Filippos; Barblu, Lucie; Kwon, Douglas; Hart, M; Zupkosky, J; Freeman, Gordon James; Kavanagh, Daniel Garrett; Kaufmann, Daniel (BioMed Central, 2012) -
Small CD4 Mimetics Prevent HIV-1 Uninfected Bystander CD4 + T Cell Killing Mediated by Antibody-dependent Cell-mediated Cytotoxicity
Richard, Jonathan; Veillette, Maxime; Ding, Shilei; Zoubchenok, Daria; Alsahafi, Nirmin; Coutu, Mathieu; Brassard, Nathalie; Park, Jongwoo; Courter, Joel R.; Melillo, Bruno; Smith, Amos B.; Shaw, George M.; Hahn, Beatrice H.; Sodroski, Joseph; Kaufmann, Daniel E.; Finzi, Andrés (Elsevier, 2015)Human immunodeficiency virus type 1 (HIV-1) infection causes a progressive depletion of CD4 + T cells. Despite its importance for HIV-1 pathogenesis, the precise mechanisms underlying CD4 + T-cell depletion remain incompletely ...