Now showing items 1-20 of 82

    • Aag DNA Glycosylase Promotes Alkylation-Induced Tissue Damage Mediated by Parp1 

      Calvo, Jennifer A.; Moroski-Erkul, Catherine A.; Lake, Annabelle; Eichinger, Lindsey W.; Shah, Dharini; Jhun, Iny; Limsirichai, Prajit; Bronson, Roderick Terry; Christiani, David C.; Meira, Lisiane B.; Samson, Leona D. (Public Library of Science, 2013)
      Alkylating agents comprise a major class of front-line cancer chemotherapeutic compounds, and while these agents effectively kill tumor cells, they also damage healthy tissues. Although base excision repair (BER) is essential ...
    • Acute kidney injury subphenotypes based on creatinine trajectory identifies patients at increased risk of death 

      Bhatraju, Pavan K.; Mukherjee, Paramita; Robinson-Cohen, Cassianne; O’Keefe, Grant E.; Frank, Angela J.; Christie, Jason D.; Meyer, Nuala J.; Liu, Kathleen D.; Matthay, Michael A.; Calfee, Carolyn S.; Christiani, David C.; Himmelfarb, Jonathan; Wurfel, Mark M. (BioMed Central, 2016)
      Background: Acute kidney injury (AKI) is common among intensive care unit (ICU) patients. AKI is highly heterogeneous, with variable links to poor outcomes. Current approaches to classify AKI severity and identify patients ...
    • Adiponectin Gene Polymorphisms and Acute Respiratory Distress Syndrome Susceptibility and Mortality 

      Ahasic, Amy M.; Zhao, Yang; Su, Li; Sheu, Chau-Chyun; Thompson, B. Taylor; Christiani, David C. (Public Library of Science, 2014)
      Rationale: Adiponectin is an anti-inflammatory adipokine that is the most abundant gene product of adipose tissue. Lower levels have been observed in obesity, insulin resistance, and in critical illness. However, elevated ...
    • Arsenic is associated with reduced effect of folic acid in myelomeningocele prevention: a case control study in Bangladesh 

      Mazumdar, Maitreyi; Ibne Hasan, Md Omar Sharif; Hamid, Rezina; Valeri, Linda; Paul, Ligi; Selhub, Jacob; Rodrigues, Ema G; Silva, Fareesa; Mia, Selim; Mostofa, Md Golam; Quamruzzaman, Quazi; Rahman, Mahmuder; Christiani, David C (BioMed Central, 2015)
      Background: Arsenic induces neural tube defects in several animal models, but its potential to cause neural tube defects in humans is unknown. Our objective was to investigate the associations between maternal arsenic ...
    • Association of Expired Nitric Oxide with Occupational Particulate Exposure 

      Kim, Jee Young; Wand, Matthew P; Hauser, Russ B.; Mukherjee, Sutapa; Herrick, Robert F.; Christiani, David C. (2003)
      Particulate air pollution has been associated with adverse respiratory health effects. This study assessed the utility of expired nitric oxide to detect acute airway responses to metal-containing fine particulates. Using ...
    • Association Test Based on SNP Set: Logistic Kernel Machine Based Test vs. Principal Component Analysis 

      Zhao, Yang; Chen, Feng; Zhai, Rihong; Lin, Xihong; Diao, Nancy; Christiani, David C. (Public Library of Science, 2012)
      GWAS has facilitated greatly the discovery of risk SNPs associated with complex diseases. Traditional methods analyze SNP individually and are limited by low power and reproducibility since correction for multiple comparisons ...
    • Cancer Mortality in Chinese Chrysotile Asbestos Miners: Exposure-Response Relationships 

      Wang, Xiaorong; Yano, Eiji; Lin, Sihao; Yu, Ignatius T. S.; Lan, Yajia; Tse, Lap Ah; Qiu, Hong; Christiani, David C. (Public Library of Science, 2013)
      Objective: This study was conducted to assess the relationship of mortality from lung cancer and other selected causes to asbestos exposure levels. Methods: A cohort of 1539 male workers from a chrysotile mine in China was ...
    • Case Report: Occupationally Related Recurrent Varicella (Chickenpox) in a Hospital Nurse 

      Ku, Chih-Hung; Liu, Yu-Tien; Christiani, David C. (National Institute of Environmental Health Sciences, 2005)
      Commonly accepted outcomes of varicella-zoster virus (VZV) infections include chickenpox (primary) and shingles (recurrence or latency), as well lifetime immunity against chickenpox. We report the case of a registered nurse ...
    • The causal relevance of body mass index in different histological types of lung cancer: A Mendelian randomization study 

      Carreras-Torres, Robert; Haycock, Philip C.; Relton, Caroline L.; Martin, Richard M.; Smith, George Davey; Kraft, Peter; Gao, Chi; Tworoger, Shelley; Le Marchand, Loïc; Wilkens, Lynne R.; Park, Sungshim L.; Haiman, Christopher; Field, John K.; Davies, Michael; Marcus, Michael; Liu, Geoffrey; Caporaso, Neil E.; Christiani, David C.; Wei, Yongyue; Chen, Chu; Doherty, Jennifer A.; Severi, Gianluca; Goodman, Gary E.; Hung, Rayjean J.; Amos, Christopher I.; McKay, James; Johansson, Mattias; Brennan, Paul (Nature Publishing Group, 2016)
      Body mass index (BMI) is inversely associated with lung cancer risk in observational studies, even though it increases the risk of several other cancers, which could indicate confounding by tobacco smoking or reverse ...
    • Chronic Lung Function Decline in Cotton Textile Workers: Roles of Historical and Recent Exposures to Endotoxin 

      Shi, Ping; Mehta, Amar J.; Hang, Jing-qing; Zhang, Hongxi; Dai, Helian; Su, Li; Eisen, Ellen A.; Christiani, David C. (National Institute of Environmental Health Sciences, 2010)
      Background: Long-term occupational exposure to cotton dust that contains endotoxin is associated with chronic respiratory symptoms and excessive decline in forced expiratory volume in 1 sec (FEV1), but the mechanisms of ...
    • Circulating Mitochondrial DNA in Patients in the ICU as a Marker of Mortality: Derivation and Validation 

      Nakahira, Kiichi; Kyung, Sun-Young; Rogers, Angela J.; Gazourian, Lee; Youn, Sojung; Massaro, Anthony F.; Quintana, Carolina; Osorio, Juan C.; Wang, Zhaoxi; Zhao, Yang; Lawler, Laurie A.; Christie, Jason D.; Meyer, Nuala J.; Causland, Finnian R. Mc.; Waikar, Sushrut S.; Waxman, Aaron B.; Chung, Raymond T.; Bueno, Raphael; Rosas, Ivan O.; Fredenburgh, Laura E.; Baron, Rebecca M.; Christiani, David C.; Hunninghake, Gary M.; Choi, Augustine M. K. (Public Library of Science, 2013)
      Background: Mitochondrial DNA (mtDNA) is a critical activator of inflammation and the innate immune system. However, mtDNA level has not been tested for its role as a biomarker in the intensive care unit (ICU). We hypothesized ...
    • Contaminated Turmeric Is a Potential Source of Lead Exposure for Children in Rural Bangladesh 

      Gleason, Kelsey; Shine, James P.; Shobnam, Nadia; Rokoff, Lisa B.; Suchanda, Hafiza Sultana; Ibne Hasan, Md Omar Sharif; Mostofa, Golam; Amarasiriwardena, Chitra; Quamruzzaman, Quazi; Rahman, Mahmuder; Kile, Molly L.; Bellinger, David C.; Christiani, David C.; Wright, Robert O.; Mazumdar, Maitreyi (Hindawi Publishing Corporation, 2014)
      Background. During the conduct of a cohort study intended to study the associations between mixed metal exposures and child health outcomes, we found that 78% of 309 children aged 20–40 months evaluated in the Munshiganj ...
    • A cross sectional study of anemia and iron deficiency as risk factors for arsenic-induced skin lesions in Bangladeshi women 

      Kile, Molly L.; Faraj, Joycelyn M.; Ronnenberg, Alayne G.; Quamruzzaman, Quazi; Rahman, Mahmudar; Mostofa, Golam; Afroz, Sakila; Christiani, David C. (BioMed Central, 2016)
      Background: In the Ganges Delta, chronic arsenic poisoning is a health concern affecting millions of people who rely on groundwater as their potable water source. The prevalence of anemia is also high in this region, ...
    • East meets West: ethnic differences in epidemiology and clinical behaviors of lung cancer between East Asians and Caucasians 

      Zhou, Wei; Christiani, David C. (Sun Yat-sen University Cancer Center, 2011)
      Lung cancer is the leading cause of cancer death worldwide, with large variation of the incidence and mortality across regions. Although the mortality of lung cancer has been decreasing, or steady in the US, it has been ...
    • Effect Modification of Air Pollution on Urinary 8-Hydroxy-2'-Deoxyguanosine by Genotypes: An Application of the Multiple Testing Procedure to Identify Significant SNP Interactions 

      Ren, Cizao; Vokonas, Pantel S; Suh MacIntosh, Helen H.; Fang, Shona C.; Christiani, David C.; Schwartz, Joel David (BioMed Central, 2010)
      Background: Air pollution is associated with adverse human health, but mechanisms through which pollution exerts effects remain to be clarified. One suggested pathway is that pollution causes oxidative stress. If so, ...
    • Effects of Air Pollution and Blood Mitochondrial DNA Methylation on Markers of Heart Rate Variability 

      Byun, Hyang‐Min; Colicino, Elena; Trevisi, Letizia; Fan, Tianteng; Christiani, David C.; Baccarelli, Andrea A. (Wiley-Blackwell, 2016)
      Background: The mitochondrion is the primary target of oxidative stress in response to exogenous environments. Mitochondrial DNA (mtDNA) is independent from nuclear DNA and uses separate epigenetic machinery to regulate ...
    • Environmental Organochlorines and Semen Quality: Results of a Pilot Study 

      Hauser, Russ B.; Altshul, Larisa M.; Chen, Zuying; Ryan, Louise Marie; Overstreet, James; Schiff, Isaac; Christiani, David C. (National Institute of Environmental Health Sciences, 2002)
      There have been numerous studies that suggest that sperm concentrations (sperm counts) are declining in men. However, other studies suggest that sperm counts are not declining or may be increasing in some areas. Although ...
    • Estimating Effects of Arsenic Exposure During Pregnancy on Perinatal Outcomes in a Bangladeshi Cohort 

      Kile, Molly L.; Cardenas, Andres; Rodrigues, Ema; Mazumdar, Maitreyi; Dobson, Christine; Golam, Mostofa; Quamruzzaman, Quazi; Rahman, Mahmudar; Christiani, David C. (Lippincott Williams & Wilkins, 2015)
      Background: The relationship between arsenic and birth weight is not well understood. The objective was to evaluate the causal relationship between prenatal arsenic exposure and birth weight considering the potential ...
    • Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans 

      Parikh, Samir Mukund; Mammoto, Tadanori; Schultz, Aylit; Yuan, Hai-Tao; Christiani, David C.; Karumanchi, Subbian Ananth; Sukhatme, Vikas Pandurang (Public Library of Science, 2006)
      Background: Acute respiratory distress syndrome (ARDS) is a devastating complication of numerous underlying conditions, most notably sepsis. Although pathologic vascular leak has been implicated in the pathogenesis of ARDS ...
    • Firefighters and On-duty Deaths From Coronary Heart Disease: A Case Control Study 

      Kales, Stefanos Nicholas; Soteriades, Elpidoforos S.; Christoudias, Stavros G; Christiani, David C. (BioMed Central, 2003)
      Background: Coronary heart disease (CHD) is responsible for 45% of on-duty deaths among United States firefighters. We sought to identify occupational and personal risk factors associated with on-duty CHD death. Methods: ...