Browsing by Author "Chen, Jing"

Now showing items 1-20 of 21

    • Altered Cholesterol Homeostasis in Aged Macrophages Linked to Neovascular Macular Degeneration 

      Chen, Jing; Smith, Lois Elaine Hodgson (Elsevier BV, 2013)
      Abnormal lipid metabolism has been linked to age-related macular degeneration (AMD); choroidal neovascularization in late AMD commonly causes blindness. Sene et al. (2013) now demonstrate that in aged macrophages decreased ...

    • Choroid Sprouting Assay: An Ex Vivo Model of Microvascular Angiogenesis 

      Shao, Zhuo; Friedlander, Mollie; Hurst, Christian G.; Cui, Zhenghao; Pei, Dorothy T.; Evans, Lucy P.; Juan, Aimee M.; Tahir, Houda; Duhamel, François; Chen, Jing; Sapieha, Przemyslaw; Chemtob, Sylvain; Joyal, Jean-Sébastien; Smith, Lois E. H. (Public Library of Science, 2013)
      Angiogenesis of the microvasculature is central to the etiology of many diseases including proliferative retinopathy, age-related macular degeneration and cancer. A mouse model of microvascular angiogenesis would be very ...

    • Current update on retinopathy of prematurity: screening and treatment 

      Chen, Jing; Stahl, Andreas; Hellstrom, Ann; Smith, Lois Elaine Hodgson (Ovid Technologies (Wolters Kluwer Health), 2011)
      PURPOSE OF REVIEW: Despite current treatments, retinopathy of prematurity (ROP) remains a major cause of blindness in premature infants and the incidence is increasing with increased survival of infants born at very early ...

    • Cytochrome P450 2C8 ω3-long-chain polyunsaturated fatty acid metabolites increase mouse retinal pathologic neovascularization--brief report. 

      Shao, Zhuo; Fu, Zhong Jie; Stahl, A.; Joyal, Julie Anne; Hatton, Colin Paul; Juan, A.; Hurst, C.; Evans, L.; Cui, Z.; Pei, D.; Gong, Yan; Xu, D.; Tian, K.; Bogardus, H.; Edin, M. L.; Lih, F.; Sapieha, P.; Chen, Jing; Panigrahy, Dipak; Hellstrom, A.; Zeldin, D. C.; Smith, Lois Elaine Hodgson (Ovid Technologies (Wolters Kluwer Health), 2014)
      OBJECTIVE: Regulation of angiogenesis is critical for many diseases. Specifically, pathological retinal neovascularization, a major cause of blindness, is suppressed with dietary ω3-long-chain polyunsaturated fatty acids ...

    • DNA Sequence Variants in PPARGC1A, a Gene Encoding a Coactivator of the ω-3 LCPUFA Sensing PPAR-RXR Transcription Complex, Are Associated with NV AMD and AMD-Associated Loci in Genes of Complement and VEGF Signaling Pathways 

      SanGiovanni, John Paul; Chen, Jing; Sapieha, Przemyslaw; Aderman, Christopher; Stahl, Andreas; Clemons, Traci E.; Chew, Emily Y.; Smith, Lois Elaine Hodgson (Public Library of Science (PLoS), 2013)
      BACKGROUND: Increased intake of ω-3 long-chain polyunsaturated fatty acids (LCPUFAs) and use of peroxisome proliferator activator receptor (PPAR)-activating drugs are associated with attenuation of pathologic retinal ...

    • Lipid metabolites in the pathogenesis and treatment of neovascular eye disease 

      Stahl, A; Krohne, T. U.; Sapieha, P.; Chen, Jing; Hellstrom, A.; Chew, E.; Holz, F. G.; Smith, Lois Elaine Hodgson (BMJ, 2011)
      Lipids and lipid metabolites have long been known to play biological roles that go beyond energy storage and membrane structure. In age-related macular degeneration and diabetes, for example, dysregulation of lipid metabolism ...

    • LRP5 Regulates Development of Lung Microvessels and Alveoli through the Angiopoietin-Tie2 Pathway 

      Mammoto, Tadanori; Jiang, Amanda Rose; Jiang, Elizabeth Qingyu; Mammoto, Akiko; Chen, Jing; Smith, Lois Elaine Hodgson; Ingber, Donald Elliott (Public Library of Science, 2012)
      Angiogenesis is crucial for lung development. Although there has been considerable exploration, the mechanism by which lung vascular and alveolar formation is controlled is still not completely understood. Here we show ...

    • Netrin-1 – DCC Signaling Systems and Age-Related Macular Degeneration 

      SanGiovanni, John Paul; Chen, Jing; Gupta, Ankur S.; Smith, Lois E. H.; Sapieha, Przemyslaw; Lee, Phil H. (Public Library of Science, 2015)
      We conducted a nested candidate gene study and pathway-based enrichment analysis on data from a multi-national 77,000-person project on the molecular genetics of age-related macular degeneration (AMD) to identify AMD-associated ...

    • Neuronal sirtuin1 mediates retinal vascular regeneration in oxygen-induced ischemic retinopathy 

      Chen, Jing; Michan, Shaday; Juan, Aimee M.; Hurst, Christian G.; Hatton, Colman J.; Pei, Dorothy T.; Joyal, Jean-Sebastien; Evans, Lucy P.; Cui, Zhenghao; Stahl, Andreas; Sapieha, Przemyslaw; Sinclair, David Andrew; Smith, Lois Elaine Hodgson (Springer Science + Business Media, 2013)
      Regeneration of blood vessels in ischemic neuronal tissue is critical to reduce tissue damage in diseases. In proliferative retinopathy, initial vessel loss leads to retinal ischemia, which can induce either regrowth of ...

    • Optimization of an Image-Guided Laser-Induced Choroidal Neovascularization Model in Mice 

      Gong, Yan; Li, Jie; Sun, Ye; Fu, Zhongjie; Liu, Chi-Hsiu; Evans, Lucy; Tian, Katherine; Saba, Nicholas; Fredrick, Thomas; Morss, Peyton; Chen, Jing; Smith, Lois E. H. (Public Library of Science, 2015)
      The mouse model of laser-induced choroidal neovascularization (CNV) has been used in studies of the exudative form of age-related macular degeneration using both the conventional slit lamp and a new image-guided laser ...

    • Propranolol Inhibition of β-Adrenergic Receptor Does Not Suppress Pathologic Neovascularization in Oxygen-Induced Retinopathy 

      Chen, Jing; Joyal, Jean-Sebastian; Hatton, Colman J.; Juan, Aimee M.; Pei, Dorothy T.; Hurst, Christian G.; Xu, Dan; Stahl, Andreas; Hellstrom, Ann; Smith, Lois Elaine Hodgson (Association for Research in Vision and Ophthalmology (ARVO), 2012)
      Purpose.: Retinopathy of prematurity (ROP) is a leading cause of blindness in children and is, in its most severe form, characterized by uncontrolled growth of vision-threatening pathologic vessels. Propranolol, a nonselective ...

    • Protective inflammasome activation in AMD 

      Chen, Jing; Smith, Lois Elaine Hodgson (Nature Publishing Group, 2012)
      Age-related macular degeneration (AMD) is the most common cause of blindness in the elderly. AMD progression is associated with alterations in inflammatory pathways and the immune system. A new study identifies a protective ...

    • Resveratrol Inhibits Pathologic Retinal Neovascularization in Vldlr -/- Mice 

      Hua, Jing; Guerin, Karen I.; Chen, Jing; Michán, Shaday; Stahl, Andreas; Krah, Nathan M.; Seaward, Molly R.; Dennison, Roberta; Juan, Aimee M.; Hatton, Colman J.; Sapieha, Przemyslaw; Sinclair, David Andrew; Smith, Lois Elaine Hodgson (Association for Research in Vision and Ophthalmology (ARVO), 2011)
      PURPOSE: Macular telangiectasia (MacTel) is a vision-threatening retinal disease with unknown pathogenesis and no approved treatment. Very low-density lipoprotein receptor mutant mice (Vldlr(-/-)) exhibit critical features ...

    • Retinal expression of small non-coding RNAs in a murine model of proliferative retinopathy 

      Liu, Chi-Hsiu; Wang, Zhongxiao; Sun, Ye; SanGiovanni, John Paul; Chen, Jing (Nature Publishing Group, 2016)
      Ocular neovascularization is a leading cause of blindness in proliferative retinopathy. Small non-coding RNAs (sncRNAs) play critical roles in both vascular and neuronal development of the retina through post-transcriptional ...

    • Retinal Expression of Wnt-Pathway Mediated Genes in Low-Density Lipoprotein Receptor-Related Protein 5 (Lrp5) Knockout Mice 

      Krah, Nathan M.; Seaward, Molly R.; Joyal, Jean-Sebastian; Juan, Aimee M.; Hatton, Colman J.; Willett, Keirnan L.; Sapieha, Przemyslaw; Chen, Jing; Stahl, Andreas; Dennison, Roberta Jean; Smith, Lois Elaine Hodgson; Aderman, Christopher M. (Public Library of Science, 2012)
      Mutations in low-density lipoprotein receptor-related protein 5 (Lrp5) impair retinal angiogenesis in patients with familial exudative vitreoretinopathy (FEVR), a rare type of blinding vascular eye disease. The defective ...

    • Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1 

      Joyal, Jean-Sébastien; Sun, Ye; Gantner, Marin L; Shao, Zhuo; Evans, Lucy P; Saba, Nicholas; Fredrick, Thomas; Burnim, Samuel; Kim, Jin Sung; Patel, Gauri; Juan, Aimee M; Hurst, Christian G; Hatton, Colman J; Cui, Zhenghao; Pierce, Kerry A; Bherer, Patrick; Aguilar, Edith; Powner, Michael B; Vevis, Kristis; Boisvert, Michel; Fu, Zhongjie; Levy, Emile; Fruttiger, Marcus; Packard, Alan Brent; Rezende, Flavio A; Maranda, Bruno; Sapieha, Przemyslaw; Chen, Jing; Friedlander, Martin; Clish, Clary B; Smith, Lois Elaine Hodgson (Nature Publishing Group, 2016)
      Tissues with high metabolic rates often use lipids, as well as glucose, for energy, conferring a survival advantage during feast and famine1. Current dogma suggests that high-energy–consuming photoreceptors depend on ...

    • Sirtuin1 Over-Expression Does Not Impact Retinal Vascular and Neuronal Degeneration in a Mouse Model of Oxygen-Induced Retinopathy 

      Michan, Shaday; Juan, Aimee M.; Hurst, Christian G.; Cui, Zhenghao; Evans, Lucy P.; Hatton, Colman J.; Pei, Dorothy T.; Ju, Meihua; Sinclair, David A.; Smith, Lois E. H.; Chen, Jing (Public Library of Science, 2014)
      Proliferative retinopathy is a leading cause of blindness, including retinopathy of prematurity (ROP) in children and diabetic retinopathy in adults. Retinopathy is characterized by an initial phase of vessel loss, leading ...

    • SOCS3 in retinal neurons and glial cells suppresses VEGF signaling to prevent pathological neovascular growth 

      Sun, Ye; Ju, Meihua; Lin, Zhiqiang; Fredrick, T. W.; Evans, L. P.; Tian, Katherine; Saba, N. J.; Morss, P. C.; Pu, William T.; Chen, Jing; Stahl, A.; Joyal, Jean; Smith, Lois Elaine Hodgson (American Association for the Advancement of Science (AAAS), 2015)
      Accumulating evidence indicates that retinal neuroglia and neural cells contribute to neovascularization in proliferative retinopathy, but the controlling molecular interactions are not well known. We identified a mechanism ...

    • Twist1 Controls Lung Vascular Permeability and Endotoxin-Induced Pulmonary Edema by Altering Tie2 Expression 

      Mammoto, Tadanori; Jiang, Elisabeth; Jiang, Amanda; Lu, Yongbo; Juan, Aimee M.; Chen, Jing; Mammoto, Akiko (Public Library of Science, 2013)
      Tight regulation of vascular permeability is necessary for normal development and deregulated vascular barrier function contributes to the pathogenesis of various diseases, including acute respiratory distress syndrome, ...

    • TWIST1 Integrates Endothelial Responses to Flow in Vascular Dysfunction and Atherosclerosis 

      Mahmoud, Marwa M.; Kim, Hyejeong Rosemary; Xing, Rouyu; Hsiao, Sarah; Mammoto, Akiko; Chen, Jing; Serbanovic-Canic, Jovana; Feng, Shuang; Bowden, Neil P.; Maguire, Richard; Ariaans, Markus; Francis, Sheila E.; Weinberg, Peter D.; van der Heiden, Kim; Jones, Elizabeth A.; Chico, Timothy J.A.; Ridger, Victoria; Evans, Paul C. (Lippincott Williams & Wilkins, 2016)
      Rationale: Blood flow–induced shear stress controls endothelial cell (EC) physiology during atherosclerosis via transcriptional mechanisms that are incompletely understood. The mechanosensitive transcription factor TWIST ...