Now showing items 1-20 of 58

    • An Absolute Risk Model to Identify Individuals at Elevated Risk for Pancreatic Cancer in the General Population 

      Klein, Alison P.; Lindström, Sara; Mendelsohn, Julie B.; Steplowski, Emily; Arslan, Alan A.; Bueno-de-Mesquita, H. Bas; Fuchs, Charles S.; Gallinger, Steven; Gross, Myron; Helzlsouer, Kathy; Holly, Elizabeth A.; Jacobs, Eric J.; LaCroix, Andrea; Li, Donghui; Mandelson, Margaret T.; Olson, Sara H.; Petersen, Gloria M.; Risch, Harvey A.; Stolzenberg-Solomon, Rachael Z.; Zheng, Wei; Amundadottir, Laufey; Albanes, Demetrius; Allen, Naomi E.; Bamlet, William R.; Boutron-Ruault, Marie-Christine; Buring, Julie E.; Bracci, Paige M.; Canzian, Federico; Clipp, Sandra; Cotterchio, Michelle; Duell, Eric J.; Elena, Joanne; Gaziano, J. Michael; Giovannucci, Edward L.; Goggins, Michael; Hallmans, Göran; Hassan, Manal; Hutchinson, Amy; Hunter, David J.; Kooperberg, Charles; Kurtz, Robert C.; Liu, Simin; Overvad, Kim; Palli, Domenico; Patel, Alpa V.; Rabe, Kari G.; Shu, Xiao-Ou; Slimani, Nadia; Tobias, Geoffrey S.; Trichopoulos, Dimitrios; Van Den Eeden, Stephen K.; Vineis, Paolo; Virtamo, Jarmo; Wactawski-Wende, Jean; Wolpin, Brian M.; Yu, Herbert; Yu, Kai; Zeleniuch-Jacquotte, Anne; Chanock, Stephen J.; Hoover, Robert N.; Hartge, Patricia; Kraft, Peter (Public Library of Science, 2013)
      Purpose We developed an absolute risk model to identify individuals in the general population at elevated risk of pancreatic cancer. Patients and Methods Using data on 3,349 cases and 3,654 controls from the PanScan ...
    • Adiposity and Cancer Risk: A Life Course Approach 

      Song, Mingyang (2015-04-28)
      Obesity is a risk factor for several cancers, including colorectal cancer (CRC). I and my colleagues investigated adulthood weight change and body fat distribution and its change in relation to CRC risk in the Nurses’ ...
    • Association between Body Mass Index and Prognosis of Colorectal Cancer: A Meta-Analysis of Prospective Cohort Studies 

      Lee, Junga; Meyerhardt, Jeffrey A.; Giovannucci, Edward; Jeon, Justin Y. (Public Library of Science, 2015)
      Studies have reported conflicting results on the association between body mass index (BMI) and prognosis of colorectal cancer. Therefore, we have conducted a meta-analysis of prospective studies, which examined the association ...
    • Association between plasma fluorescent oxidation products and erectile dysfunction: A prospective study 

      Yang, Shuman; Giovannucci, Edward; Bracken, Bruce; Ho, Shuk-Mei; Wu, Tianying (BioMed Central, 2015)
      Background: Existing epidemiological studies of the association between oxidative stress and erectile dysfunction (ED) are sparse and inconclusive, which is likely due to cross-sectional design and small sample size. ...
    • Association between prehospital vitamin D status and incident acute respiratory failure in critically ill patients: a retrospective cohort study 

      Thickett, David R; Moromizato, Takuhiro; Litonjua, Augusto A; Amrein, Karin; Quraishi, Sadeq A; Lee-Sarwar, Kathleen A; Mogensen, Kris M; Purtle, Steven W; Gibbons, Fiona K; Camargo, Carlos A; Giovannucci, Edward; Christopher, Kenneth B (BMJ Publishing Group, 2015)
      Objective: We hypothesise that low 25-hydroxyvitamin D (25(OH)D) levels before hospitalisation are associated with increased risk of acute respiratory failure. Design: Retrospective cohort study. Setting: Medical and ...
    • Association of Nut Consumption with Total and Cause-Specific Mortality 

      Bao, Ying; Han, Jiali; Hu, Frank B.; Giovannucci, Edward L.; Stampfer, Meir Jonathan; Willett, Walter C.; Fuchs, Charles Stewart (New England Journal of Medicine (NEJM/MMS), 2013)
      BACKGROUND: Increased nut consumption has been associated with a reduced risk of major chronic diseases, including cardiovascular disease and type 2 diabetes mellitus. However, the association between nut consumption and ...
    • Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation 

      Gusev, Alexander; Shi, Huwenbo; Kichaev, Gleb; Pomerantz, Mark; Li, Fugen; Long, Henry W.; Ingles, Sue A.; Kittles, Rick A.; Strom, Sara S.; Rybicki, Benjamin A.; Nemesure, Barbara; Isaacs, William B.; Zheng, Wei; Pettaway, Curtis A.; Yeboah, Edward D.; Tettey, Yao; Biritwum, Richard B.; Adjei, Andrew A.; Tay, Evelyn; Truelove, Ann; Niwa, Shelley; Chokkalingam, Anand P.; John, Esther M.; Murphy, Adam B.; Signorello, Lisa B.; Carpten, John; Leske, M. Cristina; Wu, Suh-Yuh; Hennis, Anslem J. M.; Neslund-Dudas, Christine; Hsing, Ann W.; Chu, Lisa; Goodman, Phyllis J.; Klein, Eric A.; Witte, John S.; Casey, Graham; Kaggwa, Sam; Cook, Michael B.; Stram, Daniel O.; Blot, William J.; Eeles, Rosalind A.; Easton, Douglas; Kote-Jarai, ZSofia; Al Olama, Ali Amin; Benlloch, Sara; Muir, Kenneth; Giles, Graham G.; Southey, Melissa C.; Fitzgerald, Liesel M.; Gronberg, Henrik; Wiklund, Fredrik; Aly, Markus; Henderson, Brian E.; Schleutker, Johanna; Wahlfors, Tiina; Tammela, Teuvo L. J.; Nordestgaard, Børge G.; Key, Tim J.; Travis, Ruth C.; Neal, David E.; Donovan, Jenny L.; Hamdy, Freddie C.; Pharoah, Paul; Pashayan, Nora; Khaw, Kay-Tee; Stanford, Janet L.; Thibodeau, Stephen N.; McDonnell, Shannon K.; Schaid, Daniel J.; Maier, Christiane; Vogel, Walther; Luedeke, Manuel; Herkommer, Kathleen; Kibel, Adam S.; Cybulski, Cezary; Wokolorczyk, Dominika; Kluzniak, Wojciech; Cannon-Albright, Lisa; Teerlink, Craig; Brenner, Hermann; Dieffenbach, Aida K.; Arndt, Volker; Park, Jong Y.; Sellers, Thomas A.; Lin, Hui-Yi; Slavov, Chavdar; Kaneva, Radka; Mitev, Vanio; Batra, Jyotsna; Spurdle, Amanda; Clements, Judith A.; Teixeira, Manuel R.; Pandha, Hardev; Michael, Agnieszka; Paulo, Paula; Maia, Sofia; Kierzek, Andrzej; Cook, Margaret; Guy, Michelle; Govindasami, Koveela; Leongamornlert, Daniel; Sawyer, Emma J.; Wilkinson, Rosemary; Saunders, Edward J.; Tymrakiewicz, Malgorzata; Dadaev, Tokhir; Morgan, Angela; Fisher, Cyril; Hazel, Steve; Livni, Naomi; Lophatananon, Artitaya; Pedersen, John; Hopper, John L.; Adolfson, Jan; Stattin, Paer; Johansson, Jan-Erik; Cavalli-Bjoerkman, Carin; Karlsson, Ami; Broms, Michael; Auvinen, Anssi; Kujala, Paula; Maeaettaenen, Liisa; Murtola, Teemu; Taari, Kimmo; Weischer, Maren; Nielsen, Sune F.; Klarskov, Peter; Roder, Andreas; Iversen, Peter; Wallinder, Hans; Gustafsson, Sven; Cox, Angela; Brown, Paul; George, Anne; Marsden, Gemma; Lane, Athene; Davis, Michael; Tillmans, Lori; Riska, Shaun; Wang, Liang; Rinckleb, Antje; Lubiski, Jan; Stegmaier, Christa; Pow-Sang, Julio; Park, Hyun; Radlein, Selina; Rincon, Maria; Haley, James; Zachariah, Babu; Kachakova, Darina; Popov, Elenko; Mitkova, Atanaska; Vlahova, Aleksandrina; Dikov, Tihomir; Christova, Svetlana; Heathcote, Peter; Wood, Glenn; Malone, Greg; Saunders, Pamela; Eckert, Allison; Yeadon, Trina; Kerr, Kris; Collins, Angus; Turner, Megan; Srinivasan, Srilakshmi; Kedda, Mary-Anne; Alexander, Kimberly; Omara, Tracy; Wu, Huihai; Henrique, Rui; Pinto, Pedro; Santos, Joana; Barros-Silva, Joao; Conti, David V.; Albanes, Demetrius; Berg, Christine; Berndt, Sonja I.; Campa, Daniele; Crawford, E. David; Diver, W. Ryan; Gapstur, Susan M.; Gaziano, J. Michael; Giovannucci, Edward; Hoover, Robert; Hunter, David J.; Johansson, Mattias; Kraft, Peter; Le Marchand, Loic; Lindström, Sara; Navarro, Carmen; Overvad, Kim; Riboli, Elio; Siddiq, Afshan; Stevens, Victoria L.; Trichopoulos, Dimitrios; Vineis, Paolo; Yeager, Meredith; Trynka, Gosia; Raychaudhuri, Soumya; Schumacher, Frederick R.; Price, Alkes L.; Freedman, Matthew L.; Haiman, Christopher A.; Pasaniuc, Bogdan (Nature Publishing Group, 2016)
      Although genome-wide association studies have identified over 100 risk loci that explain ∼33% of familial risk for prostate cancer (PrCa), their functional effects on risk remain largely unknown. Here we use genotype data ...
    • Blood Donation and Colorectal Cancer Incidence and Mortality in Men 

      Zhang, Xuehong; Ma, Jing; Wu, Kana; Chan, Andrew Tan; Fuchs, Charles Stewart; Giovannucci, Edward L. (Public Library of Science, 2012)
      Background: Although blood donations may reduce body iron stores, to date, prospective data on frequent blood donation and colorectal cancer risk are limited. Methodology/Principal Findings: We tested whether frequent ...
    • Consumption of soy foods and isoflavones and risk of type 2 diabetes: a pooled analysis of three US cohorts 

      Ding, Ming; Pan, An; Manson, JoAnn E.; Willett, Walter C.; Malik, Vasanti; Rosner, Bernard; Giovannucci, Edward; Hu, Frank B.; Sun, Qi (2016)
      Background: Evidence regarding the consumption of soy foods and isoflavones in relation to risk of type 2 diabetes (T2D) is scarce. Objective: Our study was to evaluate the association between soy food and isoflavone ...
    • CYP24A1 variant modifies the association between use of oestrogen plus progestogen therapy and colorectal cancer risk 

      Garcia-Albeniz, Xabier; Rudolph, Anja; Hutter, Carolyn; White, Emily; Lin, Yi; Rosse, Stephanie A; Figueiredo, Jane C; Harrison, Tabitha A; Jiao, Shuo; Brenner, Hermann; Casey, Graham; Hudson, Thomas J; Thornquist, Mark; Le Marchand, Loic; Potter, John; Slattery, Martha L; Zanke, Brent; Baron, John A; Caan, Bette J; Chanock, Stephen J; Berndt, Sonja I; Stelling, Deanna; Fuchs, Charles S; Hoffmeister, Michael; Butterbach, Katja; Du, Mengmeng; James Gauderman, W; Gunter, Marc J; Lemire, Mathieu; Ogino, Shuji; Lin, Jennifer; Hayes, Richard B; Haile, Robert W; Schoen, Robert E; Warnick, Greg S; Jenkins, Mark A; Thibodeau, Stephen N; Schumacher, Fredrick R; Lindor, Noralane M; Kolonel, Laurence N; Hopper, John L; Gong, Jian; Seminara, Daniela; Pflugeisen, Bethann M; Ulrich, Cornelia M; Qu, Conghui; Duggan, David; Cotterchio, Michelle; Campbell, Peter T; Carlson, Christopher S; Newcomb, Polly A; Giovannucci, Edward; Hsu, Li; Chan, Andrew T; Peters, Ulrike; Chang-Claude, Jenny (Nature Publishing Group, 2016)
      Background: Menopausal hormone therapy (MHT) use has been consistently associated with a decreased risk of colorectal cancer (CRC) in women. Our aim was to use a genome-wide gene–environment interaction analysis to identify ...
    • Dairy consumption and risk of type 2 diabetes: 3 cohorts of US adults and an updated meta-analysis 

      Chen, Mu; Sun, Qi; Giovannucci, Edward; Mozaffarian, Dariush; Manson, JoAnn E; Willett, Walter C; Hu, Frank B (BioMed Central, 2014)
      Background: The relation between consumption of different types of dairy and risk of type 2 diabetes (T2D) remains uncertain. Therefore, we aimed to evaluate the association between total dairy and individual types of dairy ...
    • Diabetes and mortality in patients with prostate cancer: a meta-analysis 

      Lee, Junga; Giovannucci, Edward; Jeon, Justin Y. (Springer International Publishing, 2016)
      Background: There are conflicting results as to the association between pre-existing diabetes and the risk of mortality in patients with prostate cancer. The purpose of this study is to estimate the influence of pre-existing ...
    • Effect of Multivitamin Supplementation on Measles Vaccine Response among HIV-Exposed Uninfected Tanzanian Infants 

      Sudfeld, Christopher Robert; Duggan, Christopher Paul; Histed, A.; Manji, K. P.; Meydani, S. N.; Aboud, S.; Wang, Molin; Giovannucci, Edward L.; Fawzi, Wafaie W. (American Society for Microbiology, 2013)
      Immunization and nutritional interventions are mainstays of child health programs in sub-Saharan Africa, yet few published data exist on their interactions. HIV-exposed (but uninfected) infants enrolled in a randomized ...
    • Effects of Vitamin D Supplementation on C-peptide and 25-hydroxyvitamin D Concentrations at 3 and 6 Months 

      Chandler, Paulette D.; Giovannucci, Edward L.; Scott, Jamil B.; Bennett, Gary G.; Ng, Kimmie; Chan, Andrew T.; Hollis, Bruce W.; Rifai, Nader; Emmons, Karen M.; Fuchs, Charles S.; Drake, Bettina F. (Nature Publishing Group, 2015)
      The link between African-Americans’ disproportionate rates of diabetes, obesity and vitamin D deficiency may be marked by C-peptide as an indicator of insulin secretion. We hypothesize that vitamin D supplementation will ...
    • Elevated circulating branched chain amino acids are an early event in pancreatic adenocarcinoma development 

      Mayers, Jared R.; Wu, Chen; Clish, Clary B.; Kraft, Peter; Torrence, Margaret E.; Fiske, Brian P.; Yuan, Chen; Bao, Ying; Townsend, Mary K.; Tworoger, Shelley S.; Davidson, Shawn M.; Papagiannakopoulos, Thales; Yang, Annan; Dayton, Talya L.; Ogino, Shuji; Stampfer, Meir J.; Giovannucci, Edward L.; Qian, Zhi Rong; Rubinson, Douglas A.; Ma, Jing; Sesso, Howard D.; Gaziano, John Michael; Cochrane, Barbara B.; Liu, Simin; Wactawski–Wende, Jean; Manson, JoAnn E.; Pollak, Michael N.; Kimmelman, Alec C.; Souza, Amanda; Pierce, Kerry; Wang, Thomas J.; Gerszten, Robert E.; Fuchs, Charles S.; Heiden, Matthew G. Vander; Wolpin, Brian M. (2014)
      Most patients with pancreatic ductal adenocarcinoma (PDAC) are diagnosed with advanced disease and survive less than 12 months1. PDAC has been linked with obesity and glucose intolerance2-4, but whether changes in circulating ...
    • Energy Imbalance and Cancer Risk 

      Keum, NaNa (2015-04-27)
      Positive energy imbalance occurs when energy intake exceeds energy expenditure. In modern society, increased consumption of caloric-dense food and reduced energy expenditure due to low physical activity and sedentary ...
    • Epigenomic Diversity of Colorectal Cancer Indicated by LINE-1 Methylation in a Database of 869 Tumors 

      Baba, Yoshifumi; Huttenhower, Curtis; Nosho, Katsuhiko; Tanaka, Noriko; Shima, Kaori; Hazra, Aditi; Schernhammer, Eva S; Hunter, David J.; Giovannucci, Edward L.; Fuchs, Charles Stewart; Ogino, Shuji (BioMed Central, 2010)
      Background: Genome-wide DNA hypomethylation plays a role in genomic instability and carcinogenesis. LINE-1 (L1 retrotransposon) constitutes a substantial portion of the human genome, and LINE-1 methylation correlates with ...
    • Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome 

      Machiela, Mitchell J.; Zhou, Weiyin; Karlins, Eric; Sampson, Joshua N.; Freedman, Neal D.; Yang, Qi; Hicks, Belynda; Dagnall, Casey; Hautman, Christopher; Jacobs, Kevin B.; Abnet, Christian C.; Aldrich, Melinda C.; Amos, Christopher; Amundadottir, Laufey T.; Arslan, Alan A.; Beane-Freeman, Laura E.; Berndt, Sonja I.; Black, Amanda; Blot, William J.; Bock, Cathryn H.; Bracci, Paige M.; Brinton, Louise A.; Bueno-de-Mesquita, H Bas; Burdett, Laurie; Buring, Julie E.; Butler, Mary A.; Canzian, Federico; Carreón, Tania; Chaffee, Kari G.; Chang, I-Shou; Chatterjee, Nilanjan; Chen, Chu; Chen, Constance; Chen, Kexin; Chung, Charles C.; Cook, Linda S.; Crous Bou, Marta; Cullen, Michael; Davis, Faith G.; De Vivo, Immaculata; Ding, Ti; Doherty, Jennifer; Duell, Eric J.; Epstein, Caroline G.; Fan, Jin-Hu; Figueroa, Jonine D.; Fraumeni, Joseph F.; Friedenreich, Christine M.; Fuchs, Charles S.; Gallinger, Steven; Gao, Yu-Tang; Gapstur, Susan M.; Garcia-Closas, Montserrat; Gaudet, Mia M.; Gaziano, J. Michael; Giles, Graham G.; Gillanders, Elizabeth M.; Giovannucci, Edward L.; Goldin, Lynn; Goldstein, Alisa M.; Haiman, Christopher A.; Hallmans, Goran; Hankinson, Susan E.; Harris, Curtis C.; Henriksson, Roger; Holly, Elizabeth A.; Hong, Yun-Chul; Hoover, Robert N.; Hsiung, Chao A.; Hu, Nan; Hu, Wei; Hunter, David J.; Hutchinson, Amy; Jenab, Mazda; Johansen, Christoffer; Khaw, Kay-Tee; Kim, Hee Nam; Kim, Yeul Hong; Kim, Young Tae; Klein, Alison P.; Klein, Robert; Koh, Woon-Puay; Kolonel, Laurence N.; Kooperberg, Charles; Kraft, Peter; Krogh, Vittorio; Kurtz, Robert C.; LaCroix, Andrea; Lan, Qing; Landi, Maria Teresa; Marchand, Loic Le; Li, Donghui; Liang, Xiaolin; Liao, Linda M.; Lin, Dongxin; Liu, Jianjun; Lissowska, Jolanta; Lu, Lingeng; Magliocco, Anthony M.; Malats, Nuria; Matsuo, Keitaro; McNeill, Lorna H.; McWilliams, Robert R.; Melin, Beatrice S.; Mirabello, Lisa; Moore, Lee; Olson, Sara H.; Orlow, Irene; Park, Jae Yong; Patiño-Garcia, Ana; Peplonska, Beata; Peters, Ulrike; Petersen, Gloria M.; Pooler, Loreall; Prescott, Jennifer; Prokunina-Olsson, Ludmila; Purdue, Mark P.; Qiao, You-Lin; Rajaraman, Preetha; Real, Francisco X.; Riboli, Elio; Risch, Harvey A.; Rodriguez-Santiago, Benjamin; Ruder, Avima M.; Savage, Sharon A.; Schumacher, Fredrick; Schwartz, Ann G.; Schwartz, Kendra L.; Seow, Adeline; Wendy Setiawan, Veronica; Severi, Gianluca; Shen, Hongbing; Sheng, Xin; Shin, Min-Ho; Shu, Xiao-Ou; Silverman, Debra T.; Spitz, Margaret R.; Stevens, Victoria L.; Stolzenberg-Solomon, Rachael; Stram, Daniel; Tang, Ze-Zhong; Taylor, Philip R.; Teras, Lauren R.; Tobias, Geoffrey S.; Van Den Berg, David; Visvanathan, Kala; Wacholder, Sholom; Wang, Jiu-Cun; Wang, Zhaoming; Wentzensen, Nicolas; Wheeler, William; White, Emily; Wiencke, John K.; Wolpin, Brian M.; Wong, Maria Pik; Wu, Chen; Wu, Tangchun; Wu, Xifeng; Wu, Yi-Long; Wunder, Jay S.; Xia, Lucy; Yang, Hannah P.; Yang, Pan-Chyr; Yu, Kai; Zanetti, Krista A.; Zeleniuch-Jacquotte, Anne; Zheng, Wei; Zhou, Baosen; Ziegler, Regina G.; Perez-Jurado, Luis A.; Caporaso, Neil E.; Rothman, Nathaniel; Tucker, Margaret; Dean, Michael C.; Yeager, Meredith; Chanock, Stephen J. (Nature Publishing Group, 2016)
      To investigate large structural clonal mosaicism of chromosome X, we analysed the SNP microarray intensity data of 38,303 women from cancer genome-wide association studies (20,878 cases and 17,425 controls) and detected ...
    • Genetic Polymorphisms of the Glycine N-Methyltransferase and Prostate Cancer Risk in the Health Professionals Follow-Up Study 

      Chen, Marcelo; Huang, Yi-Ling; Huang, Yu-Chuen; Shui, Irene M.; Giovannucci, Edward; Chen, Yen-Ching; Chen, Yi-Ming Arthur (Public Library of Science, 2014)
      Purpose Glycine N-methyltransferase (GNMT) affects genetic stability by regulating the ratio of S-adenosylmethionine to S-adenosylhomocysteine, by binding to folate, and by interacting with environmental carcinogens. In ...
    • Genetic Predisposition to Higher Body Mass Index or Type 2 Diabetes and Leukocyte Telomere Length in the Nurses' Health Study 

      Du, Mengmeng; Prescott, Jennifer; Cornelis, Marilyn; Hankinson, Susan Elizabeth; Giovannucci, Edward L.; Kraft, Phillip L.; De Vivo, Immaculata (Public Library of Science, 2013)
      Background: Although cross-sectional studies have linked higher body mass index (BMI) and type 2 diabetes (T2D) to shortened telomeres, whether these metabolic conditions play a causal role in telomere biology is unknown. ...