Now showing items 1-5 of 5

    • Candidate Causal Regulatory Effects by Integration of Expression QTLs with Complex Trait Genetic Associations 

      Nica, Alexandra C.; Montgomery, Stephen B.; Dimas, Antigone S.; Beazley, Claude; Barroso, Inês; Dermitzakis, Emmanouil T.; Gibson, Greg; Stranger, Barbara Elaine (Public Library of Science, 2010)
      The recent success of genome-wide association studies (GWAS) is now followed by the challenge to determine how the reported susceptibility variants mediate complex traits and diseases. Expression quantitative trait loci ...
    • Extensive Genetic Diversity and Substructuring Among Zebrafish Strains Revealed through Copy Number Variant Analysis 

      Brown, Kim; Dobrinski, Kimberly P.; Lee, Arthur S.; Gokcumen, Omer; Mills, Ryan; Shi, Xinghua; Chong, Wilson W. S.; Chen, Jin Yun Helen; Yoo, Paulo; David, Sthuthi; Peterson, Samuel M.; Raj, Towfique; Choy, Kwong Wai; Stranger, Barbara; Williamson, Robin E.; Zon, Leonard Ira; Freeman, Jennifer L.; Lee, Charles (Proceedings of the National Academy of Sciences, 2012)
      Copy number variants (CNVs) represent a substantial source of genomic variation in vertebrates and have been associated with numerous human diseases. Despite this, the extent of CNVs in the zebrafish, an important model ...
    • Genevar: A Database and Java Application for the Analysis and Visualization of SNP-Gene Associations in eQTL Studies 

      Yang, Tsun-Po; Beazley, Claude; Montgomery, Stephen B.; Dimas, Antigone S.; Gutierrez-Arcelus, Maria; Stranger, Barbara Elaine; Deloukas, Panos; Dermitzakis, Emmanouil T. (Oxford University Press, 2010)
      Summary: Genevar (GENe Expression VARiation) is a database and Java tool designed to integrate multiple datasets, and provides analysis and visualization of associations between sequence variation and gene expression. ...
    • Independent and Population-Specific Association of Risk Variants at the IRGM Locus with Crohn's Disease 

      Prescott, Natalie J.; Dominy, Katherine M.; Kubo, Michiaki; Lewis, Cathryn M.; Fisher, Sheila A.; Redon, Richard; Blaszczyk, Katarzyna; Hudspith, Barry; Parkes, Gareth; Hosono, Naoya; Yamazaki, Keiko; Onnie, Clive M.; Forbes, Alastair; Dermitzakis, Emmanouil T.; Nakamura, Yusuke; Sanderson, Jeremy; Hurles, Matthew E.; Roberts, Roland G.; Mathew, Christopher G.; Huang, Ni; Stranger, Barbara Elaine; Mansfield, John C. (Oxford University Press, 2010)
      DNA polymorphisms in a region on chromosome 5q33.1 which contains two genes, immunity related GTPase related family, M (IRGM) and zinc finger protein 300 (ZNF300), are associated with Crohn's disease (CD). The deleted ...
    • Patterns of \(Cis\) Regulatory Variation in Diverse Human Populations 

      Montgomery, Stephen B.; Dimas, Antigone S.; Parts, Leopold; Stegle, Oliver; Ingle, Catherine E.; Sekowska, Magda; Gutierrez-Arcelus, Maria; Nisbett, James; Nica, Alexandra C.; Beazley, Claude; Durbin, Richard; Deloukas, Panos; Dermitzakis, Emmanouil T.; Stranger, Barbara Elaine; Smith, George W.; Price, Alkes; Raj, Towfique (Public Library of Science, 2012)
      The genetic basis of gene expression variation has long been studied with the aim to understand the landscape of regulatory variants, but also more recently to assist in the interpretation and elucidation of disease signals. ...