Browsing by Author "Regehr, Wade"

Now showing items 1-6 of 6

    • Autistic-like behavior and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice 

      Tsai, Peter Tzu-shin; Hull, Court; Chu, Yunxiang; Greene-Colozzi, Emily; Sadowski, Abbey R.; Leech, Jarrett M.; Steinberg, Jason; Crawley, Jacqueline N.; Regehr, Wade G.; Sahin, Mustafa (2013)

    • The calcium sensor synaptotagmin 7 is required for synaptic facilitation 

      Jackman, Skyler L.; Turecek, Josef; Belinsky, Justine E.; Regehr, Wade G. (2015)
      It has been known for over 70 years that synaptic strength is dynamically regulated in a use-dependent manner1. At synapses with a low initial release probability, closely spaced presynaptic action potentials can result ...

    • Cell Type-Specific Manipulation with GFP-Dependent Cre Recombinase 

      Tang, Jonathan C Y; Rudolph, Stephanie; Dhande, Onkar S; Abraira, Victoria E; Choi, Seungwon; Lapan, Sylvain; Drew, Iain R; Drokhlyansky, Eugene; Huberman, Andrew D; Regehr, Wade G; Cepko, Constance L (2016)
      Summary There are many transgenic GFP reporter lines that allow visualization of specific populations of cells. Using such lines for functional studies requires a method that transforms GFP into a molecule that enables ...

    • Control of Neurotransmitter Release Properties by Presynaptic Calcium 

      Thanawala, Monica Shishir (2014-06-06)
      Presynaptic terminals of neurons are optimized for neurotransmitter release, which is tightly controlled by presynaptic calcium. Here, we evaluate the role of calcium influx through voltage-gated calcium channels (VGCCs) ...

    • Promoter Decommissioning by the NuRD Chromatin Remodeling Complex Triggers Synaptic Connectivity in the Mammalian Brain 

      Yamada, Tomoko; Yang, Yue Bo; Hemberg, Martin; Yoshida, Toshimi; Cho, Ha Young; Murphy, J. Patrick; Fioravante, Diasynou; Regehr, Wade G.; Gygi, Steven P.; Georgopoulos, Katia; Bonni, Azad (Elsevier BV, 2014)
      Precise control of gene expression plays fundamental roles in brain development, but the roles of chromatin regulators in neuronal connectivity have remained poorly understood. We report that depletion of the NuRD complex ...

    • Protein kinase C is a calcium sensor for presynaptic short-term plasticity 

      Fioravante, Diasynou; Chu, YunXiang; de Jong, Arthur PH; Leitges, Michael; Kaeser, Pascal S; Regehr, Wade G (eLife Sciences Publications, Ltd, 2014)
      In presynaptic boutons, calcium (Ca2+) triggers both neurotransmitter release and short-term synaptic plasticity. Whereas synaptotagmins are known to mediate vesicle fusion through binding of high local Ca2+ to their C2 ...