Browsing by Author "Diakite, Ibrahim"
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Adaptive Landscape by Environment Interactions Dictate Evolutionary Dynamics in Models of Drug Resistance
Ogbunugafor, C. Brandon; Wylie, C. Scott; Diakite, Ibrahim; Weinreich, Daniel M.; Hartl, Daniel L. (Public Library of Science, 2016)The adaptive landscape analogy has found practical use in recent years, as many have explored how their understanding can inform therapeutic strategies that subvert the evolution of drug resistance. A major barrier to ... -
Novel Ordered Stepped-Wedge Cluster Trial Designs for Detecting Ebola Vaccine Efficacy Using a Spatially Structured Mathematical Model
Diakite, Ibrahim; Mooring, Eric Q.; Velásquez, Gustavo E.; Murray, Megan B. (Public Library of Science, 2016)Background: During the 2014 Ebola virus disease (EVD) outbreak, policy-makers were confronted with difficult decisions on how best to test the efficacy of EVD vaccines. On one hand, many were reluctant to withhold a vaccine ...