Browsing by Author "Isacson, Ole"
Now showing items 1-9 of 9
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Creation of an Open-Access, Mutation-Defined Fibroblast Resource for Neurological Disease Research
Wray, Selina; Self, Matthew; Lewis, Patrick A.; Taanman, Jan-Willem; Ryan, Natalie S.; Mahoney, Colin J.; Liang, Yuying; Devine, Michael J.; Sheerin, Una-Marie; Houlden, Henry; Morris, Huw R.; Healy, Daniel; Marti-Masso, Jose-Felix; Preza, Elisavet; Barker, Suzanne; Sutherland, Margaret; Corriveau, Roderick A.; D'Andrea, Michael; Schapira, Anthony H. V.; Uitti, Ryan J.; Guttman, Mark; Opala, Grzegorz; Jasinska-Myga, Barbara; Puschmann, Andreas; Nilsson, Christer; Espay, Alberto J.; Slawek, Jaroslaw; Gutmann, Ludwig; Boeve, Bradley F.; Boylan, Kevin; Stoessl, A. Jon; Ross, Owen A.; Maragakis, Nicholas J.; Van Gerpen, Jay; Gerstenhaber, Melissa; Gwinn, Katrina; Dawson, Ted M.; Marder, Karen S.; Clark, Lorraine N.; Przedborski, Serge E.; Finkbeiner, Steven; Rothstein, Jeffrey D.; Wszolek, Zbigniew K.; Rossor, Martin N.; Hardy, John; Isacson, Ole Stefan (Public Library of Science, 2012)Our understanding of the molecular mechanisms of many neurological disorders has been greatly enhanced by the discovery of mutations in genes linked to familial forms of these diseases. These have facilitated the generation ... -
Implanted Reuptake-deficient or Wild-type Dopaminergic Neurons Improve ON L-dopa Dyskinesias Without OFF-dyskinesias in a Rat Model of Parkinson's Disease
Vinuela, Angel; Hallett, Penelope Jane; Reske-Nielsen, C.; Patterson, M.; Sotnikova, T. D.; Caron, M. G.; Gainetdinov, R. R.; Isacson, Ole Stefan (Oxford University Press, 2008)OFF-L-dopa dyskinesias have been a surprising side-effect of intrastriatal foetal ventral mesencephalic transplantation in patients with Parkinson's disease. It has been proposed that excessive and unregulated dopaminergic ... -
Neuroinflammation Mediated by IL-1β Increases Susceptibility of Dopamine Neurons to Degeneration in an Animal Model of Parkinson's Disease
Koprich, James B; Reske-Nielsen, Casper; Mithal, Prabhakar; Isacson, Ole Stefan (BioMed Central, 2008)Background: The etiology of Parkinson's disease (PD) remains elusive despite identification of several genetic mutations. It is more likely that multiple factors converge to give rise to PD than any single cause. Here we ... -
A Nurr1 Agonist Causes Neuroprotection in a Parkinson’s Disease Lesion Model Primed with the Toll-Like Receptor 3 dsRNA Inflammatory Stimulant Poly(I:C)
Smith, Gaynor A.; Rocha, Emily M.; Rooney, Thomas; Barneoud, Pascal; McLean, Jesse R.; Beagan, Jonathan; Osborn, Teresia; Coimbra, Madeleine; Luo, Yongyi; Hallett, Penelope J.; Isacson, Ole (Public Library of Science, 2015)Dopaminergic neurons in the substantia nigra pars compacta (SNpc) are characterized by the expression of genes required for dopamine synthesis, handling and reuptake and the expression of these genes is largely controlled ... -
Oct4-Induced Reprogramming is Required for Adult Brain Neural Stem Cell Differentiation into Midbrain Dopaminergic Neurons
Deleidi, Michela; Cooper, Oliver Jamie; Hargus, Gunnar; Levy, Adam; Isacson, Ole Stefan (Public Library of Science, 2011)Neural stem cells (NSCs) lose their competency to generate region-specific neuronal populations at an early stage during embryonic brain development. Here we investigated whether epigenetic modifications can reverse the ... -
Progressive decline of glucocerebrosidase in aging and Parkinson's disease
Rocha, Emily M; Smith, Gaynor A; Park, Eric; Cao, Hongmei; Brown, Eilish; Hallett, Penelope; Isacson, Ole (BlackWell Publishing Ltd, 2015)The principal risk factor for developing most adult onset neurodegenerative diseases is aging, with incidence rising significantly after age 50. Despite research efforts, the causes of Parkinson's disease (PD) remain ... -
Proteasome Activator Enhances Survival of Huntington's Disease Neuronal Model Cells
Seo, Hyemyung; Sonntag, Kai-Christian; Kim, Woori; Cattaneo, Elena; Isacson, Ole Stefan (Public Library of Science, 2007)In patients with Huntington's disease (HD), the proteolytic activity of the ubiquitin proteasome system (UPS) is reduced in the brain and other tissues. The pathological hallmark of HD is the intraneuronal nuclear protein ... -
Reducing Amyloid Plaque Burden via Ex Vivo Gene Delivery of an Aβ-Degrading Protease: A Novel Therapeutic Approach to Alzheimer Disease
Hemming, Matthew Louis; Patterson, Michaela; Reske-Nielsen, Casper; Lin, Ling; Isacson, Ole Stefan; Selkoe, Dennis J. (Public Library of Science, 2007)Background: Understanding the mechanisms of amyloid-β protein (Aβ) production and clearance in the brain has been essential to elucidating the etiology of Alzheimer disease (AD). Chronically decreasing brain Aβ levels is ... -
Selective COX-2 Inhibition Prevents Progressive Dopamine Neuron Degeneration in a Rat Model of Parkinson's Disease
Sánchez-Pernaute, Rosario; Ferree, Andrew; Cooper, Oliver Jamie; Yu, Meixiang; Brownell, Anna-Liisa; Isacson, Ole Stefan (BioMed Central, 2004)Several lines of evidence point to a significant role of neuroinflammation in Parkinson's disease (PD) and other neurodegenerative disorders. In the present study we examined the protective effect of celecoxib, a selective ...