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Now showing items 4156-4175 of 56130
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B Cell Antigen Receptor Signal Strength and Peripheral B Cell Development are Regulated by a 9-O-Acetyl Sialic Acid Esterase
(Rockefeller University Press, 2009)We show that the enzymatic acetylation and deacetylation of a cell surface carbohydrate controls B cell development, signaling, and immunological tolerance. Mice with a mutation in sialate:O-acetyl esterase, an enzyme that ... -
B cell homeostasis and follicle confines are governed by fibroblastic reticular cells
(2014)Fibroblastic reticular cells (FRCs) are known to inhabit T cell-rich areas of lymphoid organs where they function to coordinate T cell and dendritic cell interactions. However, in vivo manipulation of FRCs has been limited ... -
B cell receptor pathway in chronic lymphocytic leukemia: specific role of CC-292
(Dove Medical Press, 2014)Chronic lymphocytic leukemia (CLL) is the most common adult leukemia. The current treatment paradigm involves the use of chemoimmunotherapy, when patients develop an indication for therapy. With this strategy, a majority ... -
B Cells Populating the Multiple Sclerosis Brain Mature in the Draining Cervical Lymph Nodes
(American Association for the Advancement of Science (AAAS), 2014-08-06)Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) characterized by autoimmune mediated demyelination and neurodegeneration. The CNS of patients with MS harbors expanded clones of ... -
B Vitamins, Methionine and Alcohol Intake and Risk of Colon Cancer in Relation to BRAF Mutation and CpG Island Methylator Phenotype (CIMP)
(Public Library of Science, 2011)Background: One-carbon metabolism appears to play an important role in DNA methylation reaction. Evidence suggests that a low intake of B vitamins or high alcohol consumption increases colorectal cancer risk. How one-carbon ... -
B-Crystallin Protects Retinal Tissue during Staphylococcus aureus- Induced Endophthalmitis
(American Society for Microbiology, 2008)Bacterial infections of the eye highlight a dilemma that is central to all immune-privileged sites. On the one hand, immune privilege limits inflammation to prevent bystander destruction of normal tissue and loss of vision. ... -
b-FGF Induces Corneal Blood and Lymphatic Vessel Growth in a Spatially Distinct Pattern
(Ovid Technologies (Wolters Kluwer Health), 2012)Purpose To study the spatial variances in ligand expression and angiogenic effect in response to the inflammatory response induced by b-FGF. Methods b-FGF micropellets (80ng) were implanted in the temporal side ... -
B-MYB Is Essential for Normal Cell Cycle Progression and Chromosomal Stability of Embryonic Stem Cells
(Public Library of Science, 2008)Background: The transcription factor B-Myb is present in all proliferating cells, and in mice engineered to remove this gene, embryos die in utero just after implantation due to inner cell mass defects. This lethal phenotype ... -
B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS
(The Rockefeller University Press, 2014)Activation of intrinsic growth programs that promote developmental axon growth may also facilitate axon regeneration in injured adult neurons. Here, we demonstrate that conditional activation of B-RAF kinase alone in mouse ... -
B. W. Procter and the genesis of Carlyle's "Frederick the Great"
(Harvard Library, 1953) -
Babies, Blemishes and FDA: A History of Accutane Regulation in the United States
(2002)This paper takes a journalistic approach, tracing the chronology of Accutane in the U.S. in order to fill in the gaps of the story that has inspired so much controversy. Accutane has repeatedly pushed the frontier of FDA ... -
The Baby and the Bath Water: Improving Metaphors and Analogies in High School Biology Texts
(2017-02-10)This dissertation is concerned with understanding how metaphors and analogies function in biology education and whether some of the philosophical critiques of the language used in the field of biology — and in particular ... -
Baby Steps Toward Better Pharmaceutical Care: Market Exclusivity Incentives to Research Pediatric Drug Uses Under the FDA Modernization and Accountability Act of 1997
(1998)Part I of this paper reviews the perceived need for greater pediatric drug information and previous attempts at improving pediatric pharmaceutical treatment. Part II summarizes SOSA itself in relation to current patent and ... -
Baby Universes and String Theory
(American Physical Society, 2006)The description of 4D BPS black holes in terms of branes wrapped on various cycles in a Calabi-Yau space gives us the opportunity to study various issues in quantum gravity in a definite way by means of the worldvolume ... -
BACE1 activity regulates cell surface contactin-2 levels
(BioMed Central, 2014)Background: Although BACE1 is a major therapeutic target for Alzheimer’s disease (AD), potential side effects of BACE1 inhibition are not well characterized. BACE1 cleaves over 60 putative substrates, however the majority ... -
The Bach Canon at Harvard and its dedicatee: a riddle finally solved
(Harvard Library, 2014) -
Bachelors, Divorcees, and Widowers: Does Marriage Protect Men from Type 2 Diabetes?
(Public Library of Science, 2014)While research has suggested that being married may confer a health advantage, few studies to date have investigated the role of marital status in the development of type 2 diabetes. We examined whether men who are not ... -
Bacillus spores as building blocks for stimuli-responsive materials and nanogenerators
(Nature Publishing Group, 2014) -
Bacillus subtilis cell diameter is determined by the opposing actions of two distinct cell wall synthetic systems
(Springer Science and Business Media LLC, 2019-05-13)Rod shaped bacteria grow by adding material into their cell wall via the action of two spatially distinct enzymatic systems: The Rod system moves around the cell circumference, while the class A penicillin-binding proteins ... -
Bacillus subtilis Genome Diversity
(American Society for Microbiology, 2007)Microarray-based comparative genomic hybridization (M-CGH) is a powerful method for rapidly identifying regions of genome diversity among closely related organisms. We used M-CGH to examine the genome diversity of 17 strains ...