Now showing items 56865-56884 of 57135

    • An X Chromosome Association Scan of the Norfolk Island Genetic Isolate Provides Evidence for a Novel Migraine Susceptibility Locus at Xq12 

      Maher, Bridget H.; Lea, Rod A.; Benton, Miles; Cox, Hannah C.; Bellis, Claire; Carless, Melanie; Dyer, Thomas D.; Curran, Joanne; Charlesworth, Jac C.; Schürks, Markus; Blangero, John; Griffiths, Lyn R.; Buring, Julie Elizabeth; Kurth, Tobias; Chasman, Daniel Ian; Ridker, Paul M. (Public Library of Science, 2012)
      Migraine is a common and debilitating neurovascular disorder with a complex envirogenomic aetiology. Numerous studies have demonstrated a preponderance of women affected with migraine and previous pedigree linkage studies ...
    • X-Box Binding Protein 1 Is Essential for Insulin Regulation of Pancreatic α-Cell Function 

      Akiyama, Masaru; Liew, Chong Wee; Lu, Shusheng; Hu, Jiang; Martinez, Rachael; Hambro, Ben; Kennedy, Robert T.; Kulkarni, Rohit N. (American Diabetes Association, 2013)
      Patients with type 2 diabetes (T2D) often exhibit hyperglucagonemia despite hyperglycemia, implicating defective α-cell function. Although endoplasmic reticulum (ER) stress has been suggested to underlie β-cell dysfunction ...
    • X-CAPM: An Extrapolative Capital Asset Pricing Model 

      Barberis, Nicholas; Greenwood, Robin Marc; Jin, Lawrence; Shleifer, Andrei (National Bureau of Economic Research, 2013)
      Survey evidence suggests that many investors form beliefs about future stock market returns by extrapolating past returns. Such beliefs are hard to reconcile with existing models of the aggregate stock market. We study a ...
    • X-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription 

      Yildirim, Eda; Sadreyev, Ruslan I.; Pinter, Stefan F.; Lee, Jeannie T. (2013)
      Dosage compensation in mammals occurs at two levels. In addition to balancing X-chromosome dosage between males and females via X-inactivation, mammals also balance dosage of Xs and autosomes. It has been proposed that ...
    • The X-linked Intellectual Disability Protein PHF6 Associates with the PAF1 Complex and Regulates Neuronal Migration in the Mammalian Brain 

      Zhang, Chi (2013-10-08)
      Intellectual disability is a prevalent developmental disorder for which no effective treatments are available. Mutations of the X-linked protein PHF6 cause the Börjeson-Forssman-Lehmann syndrome (BFLS) that is characterized ...
    • X-linked myotubular myopathy in Rottweiler dogs is caused by a missense mutation in Exon 11 of the MTM1 gene 

      Shelton, G Diane; Rider, Branden E; Child, Georgina; Tzannes, Sophia; Guo, Ling T; Moghadaszadeh, Behzad; Troiano, Emily C; Haase, Bianca; Wade, Claire M; Beggs, Alan H (BioMed Central, 2015)
      Background: Congenital and inherited myopathies in dogs are faithful models of human muscle diseases and are being recognized with increasing frequency. In fact, canine models of dystrophin deficient muscular dystrophy and ...
    • X-ray absorption and re-emission from an ionized outflow in the Type 1 quasi-stellar object 2MASS 234449+1221 observed by XMM-Newton 

      Pounds, K. A.; Wilkes, Belinda Jane; Page, K. L. (Oxford University Press (OUP), 2005)
      We report on the analysis of a short XMM-Newton observation of the reddened Type 1 QSO 2MASS 234449+1221 first identified in the Two Micron All-Sky Survey. The underlying X-ray continuum is found to be typical of a broad-line ...
    • X-Ray Absorption by the Hot Intergalactic Medium 

      Perna, Rosalba; Loeb, Abraham (American Astronomical Society, 1998)
      The current census of observed baryons in the local universe is still missing a significant fraction of them according to standard big bang nucleosynthesis. Numerical simulations predict that most of the missing baryons ...
    • X-ray absorption toward the red quasar 3C 212 

      Elvis, Martin S.; Fiore, Fabrizio; Mathur, Smita; Wilkes, Belinda Jane (IOP Publishing, 1994)
      A Roentgen Satellite (ROSAT) X-ray spectrum of the z = 1.049 'red quasar' 3C 212 has a strong low-energy cutoff. The spectrum can be fitted with a power law (of energy index 1.4(+0.8, -0.6) with low-energy photoelectric ...
    • X-ray and Ellipsometric Studies of Self-Assembled Monolayers of Fluorinated Chlorosilanes 

      Geer, R. E.; Stenger, D. A.; Chen, M. S.; Calvert, J. M.; Shashidhar, R.; Jeong, Y. H.; Pershan, Peter S. (American Chemical Society, 1994)
      Results of X-ray and ellipsometric studies on self-assembled monolayer films of three fluorinated chlorosilanes are presented. By inferring an index of refraction, the monolayer thicknesses obtained from both these types ...
    • X-ray and optical continua of active galactic nuclei with extreme Fe II emission 

      Lawrence, A.; Elvis, Martin S.; Wilkes, Belinda Jane; McHardy, I.; Brandt, N. (Oxford University Press (OUP), 1997)
      We present the results of ROSAT PSPC observations of three active galactic nuclei (AGN) with extremely strong Fe ii emission (PHL 1092, IRAS 07598 + 6508 and I Zw 1) and two AGN with very weak Fe ii emission (Mrk 10 and ...
    • X-Ray and Optical Studies of the Thickness Dependence of the Phase Diagram of Liquid-Crystal Films 

      Sirota, E. B.; Pershan, Peter S.; Sorensen, L. B.; Collett, J. (American Physical Society, 1987)
      A comprehensive study of the thickness dependence of the phase diagram of freely suspended films of the liquid crystal 4-n-heptyloxybenzylidene-4-n-heptylaniline (7O.7) between \(50 and 69^{\circ}C\) is reported. In thick ...
    • The X-ray and ultraviolet absorbing outflow in 3C 351 

      Mathur, Smita; Wilkes, Belinda Jane; Elvis, Martin S.; Fiore, Fabrizio (IOP Publishing, 1994)
      3C 351 (z = 0.371), and X-ray-'quiet' quasar, is one of the few quasars showing signs of a 'warm absorber' in its X-ray spectrum; i.e., partially ionized absorbing material in the line of sight whose opacity depends on its ...
    • X-RAY BINARIES IN THE ULTRAHIGH ENCOUNTER RATE GLOBULAR CLUSTER NGC 6388 

      Maxwell, J. Edward; Lugger, Phyllis M.; Cohn, Haldan N.; Heinke, Craig O.; Grindlay, Jonathan E.; Budac, Sonia A.; Drukier, Gordon A.; Bailyn, Charles D. (American Astronomical Society, 2012)
      We report the results of a joint Chandra Hubble Space Telescope study of the X-ray binary (XRB) population in the massive, high-density globular cluster NGC 6388. NGC 6388 has one of the highest predicted XRB production ...
    • X-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific Inhibitor 

      Elkins, Jonathan M.; Wang, Jing; Deng, Xianming; Pattison, Michael J.; Arthur, J. Simon C.; Erazo, Tatiana; Gomez, Nestor; Lizcano, Jose M.; Gray, Nathanael S.; Knapp, Stefan (American Chemical Society, 2013)
      The protein kinase ERK5 (MAPK7) is an emerging drug target for a variety of indications, in particular for cancer where it plays a key role mediating cell proliferation, survival, epithelial–mesenchymal transition, and ...
    • X-Ray Emission from the First Quasars 

      Haiman, Zoltan; Loeb, Abraham (American Astronomical Society, 1999)
      It is currently unknown whether the universe was reionized by quasars or stars at z greater than or similar to 5. We point out that quasars can be best distinguished from stellar systems by their X-ray emission. Based on ...
    • X-Ray Evanescent-Wave Absorption and Emission 

      Becker, R. S.; Golovchenko, Jene Andrew; Patel, J. R. (American Physical Society (APS), 1983)
      The presence and properties of x-ray evanescent waves are demonstrated detecting their absorption and their excitation in the vicinity of a target surface. The role of microscopic reversibility in relating the two cases ...
    • X-ray flare candidates in short gamma-ray bursts 

      Margutti, R; Chincarini, G.; Granot, J.; Guidorzi, C.; Berger, Edo; Bernardini, M. G.; Gehrels, N.; Soderberg, Alicia M.; Stamatikos, M.; Zaninoni, E. (Oxford University Press (OUP), 2011)
      We present the first systematic study of X-ray flare candidates in short gamma-ray bursts (SGRBs) exploiting the large 6-year Swift database with the aim to constrain the physical nature of such fluctuations. We find that ...
    • X-Ray Grazing Incidence Diffraction from Alkylsiloxane Monolayers on Silicon Wafers 

      Tidswell, I. M.; Rabedeau, T. A.; Pershan, Peter S.; Kosowsky, S. D.; Folkers, J. P.; Whitesides, George M. (American Institute of Physics, 1991)
      X‐ray reflection (both specular and off‐specular) and grazing incidence diffraction (GID) have been used to study the structure of alkylsiloxane monolayers (\(n‐C_{18}H_{37}SiO_{1.5}\)) formed by self‐assembly from solution ...
    • X-ray Induced Electrostatic Charging of Helium Films 

      Penanen, K.; Pershan, Peter S.; Regan, M. J.; Silvera, Issac F. (Springer Verlag, 1995)
      It is well known that free electrons can be held onto the free surface of liquid helium through either their own image charges or through the effect of an externally applied electric field. The resultant electrostatic ...