Browsing by Author "Bloch, Kenneth"

Now showing items 1-20 of 28

    • Adiponectin Deficiency Increases Allergic Airway Inflammation and Pulmonary Vascular Remodeling 

      Medoff, Benjamin D.; Okamoto, Yoshihisa; Leyton, Patricio; Weng, Meiqian; Sandall, Barry P.; Raher, Michael J.; Kihara, Shinji; Bloch, Kenneth Daniel; Libby, Peter; Luster, Andrew David (American Thoracic Society, 2009)
      Obesity is associated with an increased incidence and severity of asthma, as well as other lung disorders, such as pulmonary hypertension. Adiponectin (APN), an antiinflammatory adipocytokine, circulates at lower levels ...

    • Atrial natriuretic peptide is negatively regulated by microRNA-425 

      Arora, Pankaj; Wu, Connie; Khan, Abigail May; Bloch, Donald Bendit; Davis-Dusenbery, Brandi Nicole; Ghorbani, Anahita; Spagnolli, Ester; Martinez, Andrew; Ryan, Allicia; Tainsh, Laurel T.; Kim, Samuel M; Rong, Jian; Huan, Tianxiao; Freedman, Jane E.; Levy, Daniel; Miller, Karen Klahr; Hata, Akiko; Del Monte, Federica; Vandenwijngaert, Sara; Swinnen, Melissa; Janssens, Stefan; Holmes, Tara M.; Buys, Emmanuel; Bloch, Kenneth Daniel; Newton-Cheh, Christopher Holmes; Wang, Thomas (American Society for Clinical Investigation, 2013)
      Numerous common genetic variants have been linked to blood pressure, but no underlying mechanism has been elucidated. Population studies have revealed that the variant rs5068 (A/G) in the 3′ untranslated region of NPPA, ...

    • Brown Adipose Tissue Blood Flow and Mass in Obesity: A Contrast Ultrasound Study in Mice 

      Clerte, Maëva; Baron, David William; Brouckaert, Peter; Ernande, Laura; Raher, Michael J.; Flynn, Aidan W.; Picard, Michael Howard; Bloch, Kenneth; Buys, Emmanuel; Scherrer-Crosbie, Marielle (Elsevier BV, 2013)
      Background: When activated by the sympathetic nervous system, brown adipose tissue (BAT) increases energy expenditure to produce heat. Augmenting BAT mass or increasing BAT activation could potentially be used to decrease ...

    • Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation 

      O'Rourke, Caitlin; Shelton, Georgia; Hutcheson, Joshua; Burke, Megan F.; Martyn, Trejeeve; Thayer, Timothy E.; Shakartzi, Hannah R.; Buswell, Mary D.; Tainsh, Robert; Yu, Binglan; Bagchi, Aranya; Rhee, David Kwan; Wu, Connie; Derwall, Matthias; Buys, Emmanuel; Yu, Paul B.; Bloch, Kenneth; Aikawa, Elena; Bloch, Donald Bendit; Malhotra, Rajeev (MyJove Corporation, 2016)
      Cardiovascular disease is the leading cause of morbidity and mortality in the world. Atherosclerotic plaques, consisting of lipid-laden macrophages and calcification, develop in the coronary arteries, aortic valve, aorta, ...

    • Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice 

      Thoonen, Robrecht; Cauwels, Anje; Decaluwe, Kelly; Geschka, Sandra; Tainsh, Robert; Delanghe, Joris; Hochepied, Tino; De Cauwer, Lode; Rogge, Elke; Voet, Sofie; Sips, Patrick; Karas, Richard H.; Bloch, Kenneth; Vuylsteke, Marnik; Stasch, Johannes-Peter; Van de Voorde, Johan; Buys, Emmanuel; Brouckaert, Peter (Springer Nature, 2015)
      Oxidative stress, a central mediator of cardiovascular disease, results in loss of the prosthetic haem group of soluble guanylate cyclase (sGC), preventing its activation by nitric oxide (NO). Here we introduce Apo-sGC ...

    • Decreased Soluble Guanylate Cyclase Contributes to Cardiac Dysfunction Induced by Chronic Doxorubicin Treatment in Mice 

      Vandenwijngaert, Sara; Swinnen, Melissa; Walravens, Ann-Sophie; Beerens, Manu Eddy Maria; Gillijns, Hilde; Caluwé, Ellen; Tainsh, Robert; Nathan, Daniel I.; Allen, Kaitlin; Brouckaert, Peter; Bartunek, Jozef; Scherrer-Crosbie, Marielle; Bloch, Kenneth; Bloch, Donald Bendit; Janssens, Stefan P.; Buys, Emmanuel (Mary Ann Liebert Inc, 2017)
      Aims: The use of doxorubicin, a potent chemotherapeutic agent, is limited by cardiotoxicity. We tested the hypothesis that decreased soluble guanylate cyclase (sGC) enzyme activity contributes to the development of ...

    • Deletion of the Sequence Encoding the Tail Domain of the Bone Morphogenetic Protein type 2 Receptor Reveals a Bone Morphogenetic Protein 7-Specific Gain of Function 

      Leyton, Patricio A.; Beppu, Hideyuki; Pappas, Alexandra; Martyn, Trejeeve M.; Derwall, Matthias; Baron, David M.; Galdos, Rita; Bloch, Donald B.; Bloch, Kenneth D. (Public Library of Science, 2013)
      The bone morphogenetic protein (BMP) type II receptor (BMPR2) has a long cytoplasmic tail domain whose function is incompletely elucidated. Mutations in the tail domain of BMPR2 are found in familial cases of pulmonary ...

    • Effects of transdermal testosterone on natriuretic peptide levels in women: a randomized placebo-controlled pilot study 

      Lin, Eleanor; McCabe, Elizabeth; Newton-Cheh, Christopher Holmes; Bloch, Kenneth Daniel; Buys, Emmanuel; Wang, Thomas; Miller, Karen Klahr (Elsevier BV, 2012)
      Objective: To investigate whether testosterone administration alters natriuretic peptide levels in women. Design: Three-month, double-blind, randomized, placebo-controlled study. Setting: Clinical research center. Patient(s): ...

    • Functional brown adipose tissue limits cardiomyocyte injury and adverse remodeling in catecholamine-induced cardiomyopathy 

      Thoonen, Robrecht; Ernande, Laura; Cheng, Juan; Nagasaka, Yasuko; Yao, Vincent; Miranda-Bezerra, Alexandre; Chen, Chan; Chao, Wei; Panagia, Marcello; Sosnovik, David E.; Puppala, Dheeraj; Armoundas, Antonis A.; Hindle, Allyson; Bloch, Kenneth; Buys, Emmanuel; Scherrer-Crosbie, Marielle (Elsevier BV, 2015)
      Brown adipose tissue (BAT) has well recognized thermogenic properties mediated by uncoupling protein 1 (UCP1); more recently, BAT has been demonstrated to modulate cardiovascular risk factors. To investigate whether BAT ...

    • Gender-specific hypertension and responsiveness to nitric oxide in sGCa1 knockout mice 

      Buys, Emmanuel; Sips, Patrick; Vermeersch, Pieter; Raher, Michael J.; Rogge, Elke; Ichinose, Fumito; Dewerchin, Mieke; Bloch, Kenneth; Janssens, Stefan; Brouckaert, Peter (Oxford University Press (OUP), 2008)
      Aim: The effects of nitric oxide (NO) in the cardiovascular system are attributed in part to cGMP synthesis by the α1β1 isoform of soluble guanylate cyclase (sGC). Because available sGC inhibitors are neither enzyme- nor ...

    • Gender-Specific Modulation of the Response to Arterial Injury by Soluble Guanylate Cyclase α1 

      Vermeersch, Pieter; Pokreisz, Peter; Marsboom, Glenn; Gillijns, Hilde; Pellens, Marijke; Dewerchin, Mieke; Brouckaert, Peter; Janssens, Stefan; Buys, Emmanuel; Sips, Patrick; Bloch, Kenneth Daniel (Bentham Open, 2009)
      Objective: Soluble guanylate cyclase (sGC), a heterodimer composed of α and β subunits, synthesizes cGMP in response to nitric oxide (NO). NO modulates vascular tone and structure but the relative contributions of ...

    • Genetic modifiers of hypertension in soluble guanylate cyclase α1–deficient mice 

      Buys, Emmanuel; Raher, Michael J.; Kirby, Andrew; Mohd, Shahid; Baron, David William; Hayton, Sarah R.; Tainsh, Laurel T.; Sips, Patrick; Rauwerdink, Kristen M.; Yan, Qingshang; Tainsh, Robert E; Shakartzi, Hannah R.; Stevens, Christine; Decaluwé, Kelly; Rodrigues-Machado, Maria da Gloria; Malhotra, Rajeev; Van de Voorde, Johan; Wang, Tong; Brouckaert, Peter; Daly, Mark Joseph; Bloch, Kenneth Daniel (American Society for Clinical Investigation, 2012)
      Nitric oxide (NO) plays an essential role in regulating hypertension and blood flow by inducing relaxation of vascular smooth muscle. Male mice deficient in a NO receptor component, the α1 subunit of soluble guanylate ...

    • In Vivo Noninvasive Characterization of Brown Adipose Tissue Blood Flow by Contrast Ultrasound in Mice 

      Baron, David M.; Clerte, Maeva; Brouckaert, Peter; Raher, Michael J.; Flynn, Aidan W.; Zhang, Haihua; Carter, Edward Albert; Picard, Michael Howard; Bloch, Kenneth Daniel; Buys, Emmanuel; Scherrer-Crosbie, Marielle (Ovid Technologies (Wolters Kluwer Health), 2012)
      Background—Interventions to increase brown adipose tissue (BAT) volume and activation are being extensively investigated as therapies to decrease the body weight in obese subjects. Noninvasive methods to monitor these ...

    • Increased Cardiac Myocyte PDE5 Levels in Human and Murine Pressure Overload Hypertrophy Contribute to Adverse LV Remodeling 

      Vandenwijngaert, Sara; Pokreisz, Peter; Hermans, Hadewich; Gillijns, Hilde; Pellens, Marijke; Bax, Noortje A. M.; Coppiello, Giulia; Oosterlinck, Wouter; Balogh, Agnes; Papp, Zoltan; Bouten, Carlijn V. C.; Bartunek, Jozef; D'hooge, Jan; Luttun, Aernout; Verbeken, Erik; Herregods, Marie Christine; Herijgers, Paul; Bloch, Kenneth Daniel; Janssens, Stefan (Public Library of Science, 2013)
      Background: The intracellular second messenger cGMP protects the heart under pathological conditions. We examined expression of phosphodiesterase 5 (PDE5), an enzyme that hydrolyzes cGMP, in human and mouse hearts subjected ...

    • Inhaled Nitric Oxide Improves Outcomes After Successful Cardiopulmonary Resuscitation in Mice 

      Minamishima, Shizuka; Kida, Kotaro; Tokuda, Kentaro; Wang, Huifang; Sips, Patrick; Kosugi, Shizuko; Mandeville, Joseph B.; Buys, Emmanuel; Brouckaert, Peter; Liu, Philip K.; Liu, Christina; Bloch, Kenneth Daniel; Ichinose, Fumito (Ovid Technologies (Wolters Kluwer Health), 2011)
      Background—Sudden cardiac arrest (CA) is a leading cause of death worldwide. Breathing nitric oxide (NO) reduces ischemia/reperfusion injury in animal models and in patients. The objective of this study was to learn whether ...

    • Nitric oxide regulates pulmonary vascular smooth muscle cell expression of the inducible cAMP early repressor gene 

      Steinbicker, Andrea U.; Liu, Heling; Jiramongkolchai, Kim; Malhotra, Rajeev; Choe, Elizabeth Y.; Busch, Cornelius J.; Graveline, Amanda R; Kao, Sonya M.; Nagasaka, Yasuko; Ichinose, Fumito; Buys, Emmanuel; Brouckaert, Peter; Zapol, Warren Myron; Bloch, Kenneth Daniel (Elsevier BV, 2011)
      Nitric oxide (NO) regulates vascular smooth muscle cell (VSMC) structure and function, in part by activating soluble guanylate cyclase (sGC) to synthesize cGMP. The objective of this study was to further characterize the ...

    • Nitric oxide synthase 3 deficiency limits adverse ventricular remodeling after pressure overload in insulin resistance 

      Kurtz, Baptiste; Thibault, Helene B.; Raher, Michael J.; Popovich, John R.; Cawley, Sharon; Atochin, Dmitriy N.; Hayton, Sarah; Shakartzi, Hannah R.; Huang, Paul Lee; Bloch, Kenneth Daniel; Buys, Emmanuel; Scherrer-Crosbie, Marielle (American Physiological Society, 2011)
      Insulin resistance (IR) and systemic hypertension are independently associated with heart failure. We reported previously that nitric oxide synthase 3 (NOS3) has a beneficial effect on left ventricular (LV) remodeling and ...

    • Novel MicroRNA Regulators of Atrial Natriuretic Peptide Production 

      Wu, Connie; Arora, Pankaj; Agha, Obiajulu; Hurst, Liam A.; Allen, Kaitlin; Nathan, Daniel I.; Hu, Dongjian; Jiramongkolchai, Pawina; Smith, J. Gustav; Melander, Olle; Trenson, Sander; Janssens, Stefan P.; Domian, Ibrahim J.; Wang, Thomas J.; Bloch, Kenneth; Buys, Emmanuel; Bloch, Donald Bendit; Newton-Cheh, Christopher Holmes (American Society for Microbiology, 2016)
      Atrial natriuretic peptide (ANP) has a central role in regulating blood pressure in humans. Recently, microRNA 425 (miR-425) was found to regulate ANP production by binding to the mRNA of NPPA, the gene encoding ANP. mRNAs ...

    • Pathophysiology of Hypertension in the Absence of Nitric Oxide/Cyclic GMP Signaling 

      Thoonen, Robrecht; Sips, Patrick; Bloch, Kenneth Daniel; Buys, Emmanuel (Springer Science + Business Media, 2012)
      The nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling system is a well-characterized modulator of cardiovascular function, in general, and blood pressure, in particular. The availability of mice mutant for ...

    • Phosphomimetic Modulation of eNOS Improves Myocardial Reperfusion and Mimics Cardiac Postconditioning in Mice 

      Pong, Terrence; Scherrer-Crosbie, Marielle; Atochin, Dmitriy N.; Bloch, Kenneth D.; Huang, Paul L. (Public Library of Science, 2014)
      Objective: Myocardial infarction resulting from ischemia-reperfusion injury can be reduced by cardiac postconditioning, in which blood flow is restored intermittently prior to full reperfusion. Although key molecular ...