Browsing by Author "Bronson, Roderick"

Now showing items 1-20 of 41

    • Aag DNA Glycosylase Promotes Alkylation-Induced Tissue Damage Mediated by Parp1 

      Calvo, Jennifer A.; Moroski-Erkul, Catherine A.; Lake, Annabelle; Eichinger, Lindsey W.; Shah, Dharini; Jhun, Iny; Limsirichai, Prajit; Bronson, Roderick Terry; Christiani, David C.; Meira, Lisiane B.; Samson, Leona D. (Public Library of Science, 2013)
      Alkylating agents comprise a major class of front-line cancer chemotherapeutic compounds, and while these agents effectively kill tumor cells, they also damage healthy tissues. Although base excision repair (BER) is essential ...

    • Acquired MET Expression Confers Resistance to EGFR Inhibition In a Mouse Model of Glioblastoma Multiforme 

      Jun, Hyun Jung; Acquaviva, Jaime; Chi, Dorcas; Lessard, Julie; Zhu, Haihao; Woolfenden, Steve; Bronson, Roderick T.; Pfannl, Rolf; White, Forest; Housman, David E.; Iyer, Lakshmanan; Whittaker, Charles A.; Boskovitz, Abraham; Raval, Ami; Charest, Alain (2013)
      Glioblastoma Multiforme (GBM) is an aggressive brain tumor for which there is no cure. Overexpression of wild-type EGFR and loss of the tumor suppressor genes Ink4a/Arf and PTEN are salient features of this deadly cancer. ...

    • Adenomatous Polyposis Coli (APC) Is Required for Normal Development of Skin and Thymus 

      Kuraguchi, Mari; Wang, Xiu-Ping; Rothenberg, Rebecca; Ohene-Baah, Nana Yaw; Lund, Jennifer J; Bronson, Roderick Terry; Kucherlapati, Melanie Haas; Maas, Richard Louis; Kucherlapati, Raju (Public Library of Science, 2006)
      The tumor suppressor gene Apc (adenomatous polyposis coli) is a member of the Wnt signaling pathway that is involved in development and tumorigenesis. Heterozygous knockout mice for Apc have a tumor predisposition phenotype ...

    • CRISPR-mediated direct mutation of cancer genes in the mouse liver 

      Xue, Wen; Chen, Sidi; Yin, Hao; Tammela, Tuomas; Papagiannakopoulos, Thales; Joshi, Nikhil S.; Cai, Wenxin; Yang, Gillian; Bronson, Roderick; Crowley, Denise G.; Zhang, Feng; Anderson, Daniel G.; Sharp, Phillip A.; Jacks, Tyler (2014)
      The study of cancer genes in mouse models has traditionally relied on genetically-engineered strains made via transgenesis or gene targeting in embryonic stem (ES) cells1. Here we describe a new method of cancer model ...

    • Crucial Role for Early Growth Response-1 in the Transcriptional Regulation of miR-20b in Breast Cancer 

      Li, Dongping; Ilnytskyy, Yaroslav; Kovalchuk, Anna; Khachigian, Levon M.; Bronson, Roderick T.; Wang, Bo; Kovalchuk, Olga (Impact Journals LLC, 2013)
      Transcriptional regulation of miRNAs that control the pathogenesis of breast cancer remains largely unknown. Here, we showed that ionizing radiation, a known breast carcinogen, triggered the differential expression of ...

    • Developmental SHP2 dysfunction underlies cardiac hypertrophy in Noonan syndrome with multiple lentigines 

      Lauriol, Jessica; Cabrera, Janel Rodriguez; Roy, Ashbeel; Keith, Kimberly; Hough, Sara M.; Damilano, Federico; Wang, Bonnie; Segarra, Gabriel C.; Flessa, Meaghan E.; Miller, Lauren E.; Das, Saumya; Bronson, Roderick Terry; Lee, Kyu-Ho; Kontaridis, Maria Irene (American Society for Clinical Investigation, 2016)
      Hypertrophic cardiomyopathy is a common cause of mortality in congenital heart disease (CHD). Many gene abnormalities are associated with cardiac hypertrophy, but their function in cardiac development is not well understood. ...

    • DOK2 Inhibits EGFR-Mutated Lung Adenocarcinoma 

      Berger, Alice H.; Chen, Ming; Morotti, Alessandro; Janas, Justyna A.; Niki, Masaru; Bronson, Roderick T.; Taylor, Barry S.; Ladanyi, Marc; Van Aelst, Linda; Politi, Katerina; Varmus, Harold E.; Pandolfi, Pier Paolo (Public Library of Science, 2013)
      Somatic mutations in the EGFR proto-oncogene occur in ~15% of human lung adenocarcinomas and the importance of EGFR mutations for the initiation and maintenance of lung cancer is well established from mouse models and ...

    • Genetic Interaction between Tmprss2-ERG Gene Fusion and Nkx3.1-Loss Does Not Enhance Prostate Tumorigenesis in Mouse Models 

      Linn, Douglas E.; Bronson, Roderick T.; Li, Zhe (Public Library of Science, 2015)
      Gene fusions involving ETS family transcription factors (mainly TMPRSS2-ERG and TMPRSS2-ETV1 fusions) have been found in ~50% of human prostate cancer cases. Although expression of TMPRSS2-ERG or TMPRSS2-ETV1 fusion alone ...

    • Genetic Mechanisms in Apc-Mediated Mammary Tumorigenesis 

      Kuraguchi, Mari; Ohene-Baah, Nana Yaw; Sonkin, Dmitriy; Bronson, Roderick Terry; Kucherlapati, Raju (Public Library of Science, 2009)
      Many components of Wnt/\(\beta\)-catenin signaling pathway also play critical roles in mammary tumor development, yet the role of the tumor suppressor gene APC (adenomatous polyposis coli) in breast oncongenesis is unclear. ...

    • Genome analysis reveals insights into physiology and longevity of the Brandt’s bat Myotis brandtii 

      Seim, Inge; Fang, Xiaodong; Xiong, Zhiqiang; Lobanov, Alexey V.; Huang, Zhiyong; Ma, Siming; Feng, Yue; Turanov, Anton A.; Zhu, Yabing; Lenz, Tobias L.; Gerashchenko, Maxim V.; Fan, Dingding; Hee Yim, Sun; Yao, Xiaoming; Jordan, Daniel; Xiong, Yingqi; Ma, Yong; Lyapunov, Andrey N.; Chen, Guanxing; Kulakova, Oksana I.; Sun, Yudong; Lee, Sang-Goo; Bronson, Roderick T.; Moskalev, Alexey A.; Sunyaev, Shamil R.; Zhang, Guojie; Krogh, Anders; Wang, Jun; Gladyshev, Vadim N. (Nature Pub. Group, 2013)
      Bats account for one-fifth of mammalian species, are the only mammals with powered flight, and are among the few animals that echolocate. The insect-eating Brandt’s bat (Myotis brandtii) is the longest-lived bat species ...

    • Genotype Directed Therapy in Murine Mismatch Repair Deficient Tumors 

      Kucherlapati, Melanie H.; Esfahani, Shadi; Habibollahi, Peiman; Wang, Junning; Still, Eric R.; Bronson, Roderick T.; Mahmood, Umar; Kucherlapati, Raju S. (Public Library of Science, 2013)
      The PI3K/AKT/mTOR pathway has frequently been found activated in human tumors. We show that in addition to Wnt signaling dysfunction, the PI3K/AKT/mTOR pathway is often upregulated in mouse Msh2−/− initiated intestinal ...

    • The impact of the MYB-NFIB fusion proto-oncogene in vivo 

      Mikse, Oliver R.; Tchaicha, Jeremy H.; Akbay, Esra A.; Chen, Liang; Bronson, Roderick T.; Hammerman, Peter S.; Wong, Kwok-Kin (Impact Journals LLC, 2016)
      Recurrent fusion of the v-myb avian myelobastosis viral oncogene homolog (MYB) and nuclear factor I/B (NFIB) generates the MYB-NFIB transcription factor, which has been detected in a high percentage of individuals with ...

    • Induction of Histiocytic Sarcoma in Mouse Skeletal Muscle 

      Liu, Jianing; Hettmer, Simone; Milsom, Michael D.; Hofmann, Inga; Hua, Frederic; Miller, Christine; Bronson, Roderick Terry; Wagers, Amy Jo (Public Library of Science, 2012)
      Myeloid sarcomas are extramedullary accumulations of immature myeloid cells that may present with or without evidence of pathologic involvement of the bone marrow or peripheral blood, and often coincide with or precede a ...

    • Inflammation and Disintegration of Intestinal Villi in an Experimental Model for \(Vibrio\) \(parahaemolyticus\)-Induced Diarrhea 

      Ritchie, Jennifer M.; Rui, Haopeng; Zhou, Xiaohui; Iida, Tetsuya; Kodoma, Toshio; Ito, Susuma; Davis, Brigid; Bronson, Roderick Terry; Waldor, Matthew K (Public Library of Science, 2012)
      \(Vibrio\) \(parahaemolyticus\) is a leading cause of seafood-borne gastroenteritis in many parts of the world, but there is limited knowledge of the pathogenesis of \(V.\) \(parahaemolyticus\)-induced diarrhea. The absence ...

    • Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus 

      Wang, Jianxun; Mizui, Masayuki; Zeng, Li-Fan; Bronson, Roderick Terry; Finnell, Michele; Terhorst, Cox; Kyttaris, Vasileios; Tsokos, George C.; Zhang, Zhong-Yin; Kontaridis, Maria Irene (American Society for Clinical Investigation, 2016)
      Systemic lupus erythematosus (SLE) is a devastating multisystemic autoimmune disorder. However, the molecular mechanisms underlying its pathogenesis remain elusive. Some patients with Noonan syndrome, a congenital disorder ...

    • Kinase Domain Activation of FGFR2 Yields High-Grade Lung Adenocarcinoma Sensitive to a Pan-FGFR Inhibitor in a Mouse Model of NSCLC 

      Tchaicha, J. H.; Akbay, E; Altabef, A.; Mikse, O. R.; Kikuchi, E.; Rhee, K.; Liao, R; Bronson, Roderick Terry; Sholl, Lynette Marie; Meyerson, Matthew Langer; Hammerman, Peter Seth; Wong, Kwok-Kin (American Association for Cancer Research (AACR), 2014)
      Somatic mutations in Fibroblast Growth Factor Receptor 2 (FGFR2) are present in 4-5% of patients diagnosed with non-small cell lung cancer (NSCLC). Amplification and mutations in FGFR genes have been identified in patients ...

    • Metastasis-associated MCL1 and P16 copy number alterations dictate resistance to vemurafenib in a BRAFV600E patient-derived papillary thyroid carcinoma preclinical model 

      Duquette, Mark; Sadow, Peter M.; Husain, Amjad; Sims, Jennifer N.; Antonello, Zeus A.; Fischer, Andrew H.; Song, Chen; Castellanos-Rizaldos, Elena; Makrigiorgos, G. Mike; Kurebayashi, Junichi; Nose, Vania; Van Hummelen, Paul; Bronson, Roderick T.; Vinco, Michelle; Giordano, Thomas J.; Dias-Santagata, Dora; Pandolfi, Pier Paolo; Nucera, Carmelo (Impact Journals LLC, 2015)
      BRAFV600E mutation exerts an essential oncogenic function in many tumors, including papillary thyroid carcinoma (PTC). Although BRAFV600E inhibitors are available, lack of response has been frequently observed. To study ...

    • An Msh2 Conditional Knockout Mouse for Studying Intestinal Cancer and Testing Anticancer Agents 

      Kucherlapati, Melanie; Lee, Kyeryoung; Nguyen, Andrew A.; Clark, Alan B.; Hou, Harry; Rosulek, Andrew; Li, Hua; Yang, Kan; Fan, Kunhua; Lipkin, Martin; Bronson, Roderick; Jelicks, Linda; Kunkel, Thomas A.; Kucherlapati, Raju; Edelmann, Winfried (Elsevier BV, 2010-03)
      Background & Aims Mutations in the DNA mismatch repair (MMR) gene MSH2 cause Lynch Syndromes I & II, and sporadic colorectal cancers (CRCs). Msh2null mice predominantly develop lymphoma and do not accurately recapitulate ...

    • MUC1-C ACTIVATES THE TAK1 INFLAMMATORY PATHWAY IN COLON CANCER 

      Takahashi, Hidekazu; Jin, Caining; Rajabi, Hasan; Pitroda, Sean; Alam, Maroof; Ahmad, Rehan; Raina, Deepak; Hasegawa, Masanori; Suzuki, Yozo; Tagde, Ashujit; Bronson, Roderick T.; Weichselbaum, Ralph; Kufe, Donald (2015)
      The mucin 1 (MUC1) oncoprotein has been linked to the inflammatory response by promoting cytokine-mediated activation of the NF-κB pathway. The TGF-β-activated kinase 1 (TAK1) is an essential effector of proinflammatory ...

    • Mutant Mouse Models Reveal the Relative Roles of E2F1 and E2F3 In Vivo 

      Cloud, J. E.; Rogers, Catherine; Reza, Tammi; Ziebold, U.; Stone, James Robert; Picard, Michael Howard; Caron, A. M.; Bronson, Roderick Terry; Lees, J. A. (American Society for Microbiology, 2002)
      The E2F1, -2, and -3 transcription factors are key downstream targets of the retinoblastoma protein (pRB) tumor suppressor that drive expression of proliferation-associated genes. Here we use mutant mouse strains to ...