Now showing items 21-40 of 165

    • Association of Cumulative Lead Exposure with Parkinson’s Disease 

      Weisskopf, Marc G.; Weuve, Jennifer Lynn; Nie, Huiling; Saint-Hilaire, Marie-Helene; Sudarsky, Lewis Richard; Simon, David K.; Hersh, Bonnie Patricia; Schwartz, Joel David; Wright, Robert O.; Hu, Howard (National Institute of Environmental Health Sciences, 2010)
      Background: Research using reconstructed exposure histories has suggested an association between heavy metal exposures, including lead, and Parkinson’s disease (PD), but the only study that used bone lead, a biomarker of ...
    • Association of Environmental Cadmium Exposure with Pediatric Dental Caries 

      Arora, Manish; Weuve, Jennifer Lynn; Schwartz, Joel David; Wright, Robert O. (National Institute of Environmental Health Sciences, 2008)
      Background: Although animal experiments have shown that cadmium exposure results in severe dental caries, limited epidemiologic data are available on this issue. Objectives: We aimed to examine the relationship between ...
    • Association of Environmental Cadmium Exposure with Periodontal Disease in U.S. Adults 

      Arora, Manish; Weuve, Jennifer Lynn; Schwartz, Joel David; Wright, Robert O. (National Institute of Environmental Health Sciences, 2009)
      Background: Periodontal disease is a complex, multifactorial, chronic inflammatory disease that involves degradation of periodontal structures, including alveolar bone. Cadmium adversely affects bone remodeling, and it is ...
    • The Association of Meningococcal Disease with Influenza in the United States, 1989–2009 

      Jacobs, Jessica Hartman; Viboud, Cécile; Tchetgen, Eric Tchetgen; Schwartz, Joel; Steiner, Claudia; Simonsen, Lone; Lipsitch, Marc (Public Library of Science, 2014)
      Importance and Objective Prior influenza infection is a risk factor for invasive meningococcal disease. Quantifying the fraction of meningococcal disease attributable to influenza could improve understanding of viral-bacterial ...
    • Associations between air pollution and perceived stress: the Veterans Administration Normative Aging Study 

      Mehta, Amar J; Kubzansky, Laura D; Coull, Brent A; Kloog, Itai; Koutrakis, Petros; Sparrow, David; Spiro, Avron; Vokonas, Pantel; Schwartz, Joel (BioMed Central, 2015)
      Background: There is mixed evidence suggesting that air pollution may be associated with increased risk of developing psychiatric disorders. We aimed to investigate the association between air pollution and non-specific ...
    • Associations between cadmium exposure and neurocognitive test scores in a cross-sectional study of US adults 

      Ciesielski, Timothy; Bellinger, David C.; Schwartz, Joel David; Hauser, Russ B.; Wright, Robert O. (BioMed Central, 2013)
      Background: Low-level environmental cadmium exposure and neurotoxicity has not been well studied in adults. Our goal was to evaluate associations between neurocognitive exam scores and a biomarker of cumulative cadmium ...
    • Associations between Changes in City and Address Specific Temperature and QT Interval - The VA Normative Aging Study 

      Mehta, Amar J.; Kloog, Itai; Zanobetti, Antonella; Coull, Brent A.; Sparrow, David; Vokonas, Pantel; Schwartz, Joel (Public Library of Science, 2014)
      Background: The underlying mechanisms of the association between ambient temperature and cardiovascular morbidity and mortality are not well understood, particularly for daily temperature variability. We evaluated if daily ...
    • Associations between outdoor temperature and markers of inflammation: a cohort study 

      Halonen, Jaana I; Zanobetti, Antonella; Sparrow, David; Vokonas, Pantel S; Schwartz, Joel David (BioMed Central, 2010)
      Background: Associations between ambient temperature and cardiovascular mortality are well established. This study investigated whether inflammation could be part of the mechanism leading to temperature-related cardiovascular ...
    • Associations of Early Childhood Manganese and Lead Coexposure with Neurodevelopment 

      Henn, Birgit Claus; Schnaas, Lourdes; Lamadrid-Figueroa, Héctor; Hernández-Avila, Mauricio; Hu, Howard; Téllez-Rojo, Martha María; Ettinger, Adrienne S; Schwartz, Joel David; Amarasiriwardena, Chitra J.; Bellinger, David C.; Wright, Robert O. (National Institute of Environmental Health Sciences, 2011)
      Background: Most toxicologic studies focus on a single agent, although this does not reflect real-world scenarios in which humans are exposed to multiple chemicals. Objectives: We prospectively studied manganese–lead ...
    • Associations of Fine Particulate Matter Species with Mortality in the United States: A Multicity Time-Series Analysis 

      Dai, Lingzhen; Zanobetti, Antonella; Koutrakis, Petros; Schwartz, Joel D. (NLM-Export, 2014)
      Background: Epidemiological studies have examined the association between PM2.5 and mortality, but uncertainty remains about the seasonal variations in PM2.5-related effects and the relative importance of species. Objectives: ...
    • Associations of Toenail Arsenic, Cadmium, Mercury, Manganese, and Lead with Blood Pressure in the Normative Aging Study 

      Mordukhovich, Irina; Wright, Robert O.; Hu, Howard; Amarasiriwardena, Chitra J.; Baccarelli, Andrea; Litonjua, Augusto Ampil; Sparrow, David; Vokonas, Pantel S; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2012)
      Background: Arsenic, cadmium, mercury, and lead are associated with cardiovascular disease in epidemiologic research. These associations may be mediated by direct effects of the metals on blood pressure (BP) elevation. ...
    • Baseline Repeated Measures from Controlled Human Exposure Studies: Associations between Ambient Air Pollution Exposure and the Systemic Inflammatory Biomarkers IL-6 and Fibrinogen 

      Thompson, Aaron M.S.; Zanobetti, Antonella; Silverman, Frances; Schwartz, Joel David; Coull, Brent Andrew; Urch, Bruce; Speck, Mary; Brook, Jeffrey R.; Manno, Michael; Gold, Diane R. (National Institute of Environmental Health Sciences, 2009)
      Introduction: Systemic inflammation may be one of the mechanisms mediating the association between ambient air pollution and cardiovascular morbidity and mortality. Interleukin-6 (IL-6) and fibrinogen are biomarkers of ...
    • Biomarkers of Lead Exposure and DNA Methylation within Retrotransposons 

      Bollati, Valentina; Tarantini, Letizia; Hu, Howard; Schwartz, Joel David; Wright, Rosalind Jo; Park, Sung Kyun; Sparrow, David; Vokonas, Pantel S; Baccarelli, Andrea; Wright, Robert O. (National Institute of Environmental Health Sciences, 2010)
      Background: DNA methylation is an epigenetic mark that regulates gene expression. Changes in DNA methylation within white blood cells may result from cumulative exposure to environmental metals such as lead. Bone lead, a ...
    • Black Carbon Exposure, Oxidative Stress Genes, and Blood Pressure in a Repeated-measures Study 

      Mordukhovich, Irina; Wilker, Elissa Hope; Suh MacIntosh, Helen H.; Wright, Robert O.; Sparrow, David; Vokonas, Pantel S; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2009)
      Background: Particulate matter (PM) air pollution has been associated with cardiovascular morbidity and mortality, and elevated blood pressure (BP) is a known risk factor for cardiovascular disease. A small number of studies ...
    • Black Carbon Exposures, Blood Pressure, and Interactions with Single Nucleotide Polymorphisms in MicroRNA Processing Genes 

      Wilker, Elissa Hope; Baccarelli, Andrea; Suh MacIntosh, Helen H.; Vokonas, Pantel S; Wright, Robert O.; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2010)
      Background: Black carbon (BC) is a marker of traffic pollution that has been associated with blood pressure (BP), but findings have been inconsistent. MicroRNAs (miRNAs) are emerging as key regulators of gene expression, ...
    • Blood Epigenetic Age may Predict Cancer Incidence and Mortality 

      Zheng, Yinan; Joyce, Brian T.; Colicino, Elena; Liu, Lei; Zhang, Wei; Dai, Qi; Shrubsole, Martha J.; Kibbe, Warren A.; Gao, Tao; Zhang, Zhou; Jafari, Nadereh; Vokonas, Pantel; Schwartz, Joel; Baccarelli, Andrea A.; Hou, Lifang (Elsevier, 2016)
      Biological measures of aging are important for understanding the health of an aging population, with epigenetics particularly promising. Previous studies found that tumor tissue is epigenetically older than its donors are ...
    • Blood Lead Levels and Major Depressive Disorder, Panic Disorder, and Generalized Anxiety Disorder in US Young Adults 

      Bouchard, Maryse F.; Bellinger, David C; Weuve, Jennifer; Matthews-Bellinger, Julia; Gilman, Stephen Edward; Wright, Robert O.; Schwartz, Joel David; Weisskopf, Marc G. (American Medical Association (AMA), 2009)
      CONTEXT: Lead is a ubiquitous neurotoxicant, and adverse cognitive and behavioral effects are well-documented in children and occupationally exposed adults but not in adults with low environmental exposure. OBJECTIVE: To ...
    • Blood Telomere Length Attrition and Cancer Development in the Normative Aging Study Cohort 

      Hou, Lifang; Joyce, Brian Thomas; Gao, Tao; Liu, Lei; Zheng, Yinan; Penedo, Frank J.; Liu, Siran; Zhang, Wei; Bergan, Raymond; Dai, Qi; Vokonas, Pantel; Hoxha, Mirjam; Schwartz, Joel; Baccarelli, Andrea (Elsevier, 2015)
      Background: Accelerated telomere shortening may cause cancer via chromosomal instability, making it a potentially useful biomarker. However, publications on blood telomere length (BTL) and cancer are inconsistent. We ...
    • Brachial Artery Responses to Ambient Pollution, Temperature, and Humidity in People with Type 2 Diabetes: A Repeated-Measures Study 

      Zanobetti, Antonella; Luttmann-Gibson, Heike; Horton, Edward S.; Cohen, Allison; Coull, Brent A.; Hoffmann, Barbara; Schwartz, Joel D.; Mittleman, Murray A.; Li, Yongsheng; Stone, Peter H.; de Souza, Celine; Lamparello, Brooke; Koutrakis, Petros; Gold, Diane R. (National Institute of Environmental Health Sciences, 2014)
      Background: Extreme weather and air pollution are associated with increased cardiovascular risk in people with diabetes. Objectives: In a population with diabetes, we conducted a novel assessment of vascular brachial artery ...
    • Cadmium Exposure and Neurodevelopmental Outcomes in U.S. Children 

      Ciesielski, Timothy; Weuve, Jennifer Lynn; Bellinger, David C.; Schwartz, Joel David; Lanphear, Bruce; Wright, Robert O. (National Institute of Environmental Health Sciences, 2012)
      Background: Low-level environmental cadmium exposure in children may be associated with adverse neurodevelopmental outcomes. Objective: Our aim was to evaluate associations between urinary cadmium concentration and reported ...