Now showing items 21-29 of 29

    • Predicting and Manipulating Cardiac Drug Inactivation by the Human Gut Bacterium Eggerthella lenta 

      Haiser, Henry J.; Gootenberg, David Benjamin; Chatman, Kelly; Sirasani, Gopal; Balskus, Emily Patricia; Turnbaugh, Peter (American Association for the Advancement of Science (AAAS), 2013)
      Despite numerous examples of the effects of the human gastrointestinal microbiome on drug efficacy and toxicity, there is often an incomplete understanding of the underlying mechanisms. Here, we dissect the inactivation ...
    • Production of Stealthin C Involves an S–N-Type Smiles Rearrangement 

      Wang, Peng; Hong, Gloria J.; Wilson, Matthew Ryan; Balskus, Emily Patricia (American Chemical Society (ACS), 2017)
      The kinamycin family of aromatic polyketide natural products contains an atypical angucycline ring system substituted with a diazo group. The enzymatic chemistry involved in constructing both of these structural features ...
    • Rescuing Auxotrophic Microorganisms with Nonenzymatic Chemistry 

      Lee, Yunmi; Umeano, Afoma; Balskus, Emily Patricia (Wiley-Blackwell, 2013)
      Organic chemistry to the rescue: Two unrelated nonenzymatic chemical reactions can support the growth of auxotrophic E. coli strains by generating essential nutrients in situ. These biocompatible reactions, which take place ...
    • Spin-transition behaviour in chains of FeII bridged by 4-substituted 1,2,4-triazoles carrying alkyl tails 

      Roubeau, Olivier; Alcazar Gomez, José M.; Balskus, Emily Patricia; Kolnaar, Jeroen J. A.; Haasnoot, Jaap G.; Reedijk, Jan (Royal Society of Chemistry (RSC), 2001)
      A family of polymeric 1-dimensional chains of iron(II) species showing the spin-crossover phenomenon has been synthesized using 4-n-alkyl-1,2,4-triazoles as bridging ligands. The influence of the length of the alkyl tails ...
    • Structural Analysis of Spiro β-Lactone Proteasome Inhibitors 

      Groll, Michael; Balskus, Emily Patricia; Jacobsen, Eric N. (American Chemical Society (ACS), 2008)
      Spiro β-lactone-based proteasome inhibitors were discovered in the context of an asymmetric catalytic total synthesis of the natural product (+)-lactacystin (1). Lactone 4 was found to be a potent inhibitor of the 26S ...
    • Structural Basis of Colibactin Activation by the ClbP Peptidase 

      Velilla, Jose; Volpe, Matthew; Kenney, Grace; Walsh, Richard; Balskus, Emily; Gaudet, Rachelle (Springer Science and Business Media LLC, 2022-10-17)
      Colibactin, a DNA crosslinking agent produced by gut bacteria, is implicated in colorectal cancer. Its biosynthesis uses a prodrug resistance mechanism: a non-toxic precursor assembled in the cytoplasm is activated after ...
    • Synthetic Studies toward Hennoxazole A. Use of a Selective Bisoxazole Alkylation as the Key Fragment Coupling 

      Smith, Thomas E.; Balskus, Emily Patricia (Japan Institute of Heterocyclic Chemistry, 2002)
      A model system for side chain fragment coupling to the core of hennoxazole A is investigated. Lateral metallation of a C13-TBS-protected bisoxazole, using lithium diethylamide, allows for selective and efficient alkylation at C15.
    • Understanding and Preventing Disease-Associated Anaerobic Choline Metabolism by the Human Gut Microbiota 

      Bodea, Smaranda (2016-05-17)
      The consortium of microorganisms inhabiting the human gastrointestinal tract, our gut microbiota, has an extensive set of metabolic capabilities that directly influence human health. Over the past decade, DNA sequencing ...
    • Using Non-Enzymatic Chemistry to Influence Microbial Metabolism 

      Wallace, Stephen; Schultz, Erica Elizabeth; Balskus, Emily Patricia (Elsevier BV, 2015)
      The structural manipulation of small molecule metabolites occurs in all organisms and plays a fundamental role in essentially all biological processes. Despite an increasing interest in developing new, non-enzymatic chemical ...