Now showing items 21-40 of 41

    • Interactions of nanomaterials and biological systems: Implications to personalized nanomedicine 

      Zhang, Xue-Qing; Xu, Xiaoyang; Bertrand, Nicolas; Pridgen, Eric; Swami, Archana; Farokhzad, Omid Cameron (Elsevier BV, 2012)
      The application of nanotechnology to personalized medicine provides an unprecedented opportunity to improve the treatment of many diseases. Nanomaterials offer several advantages as therapeutic and diagnostic tools due to ...
    • Microfluidic technologies for accelerating the clinical translation of nanoparticles 

      Valencia, Pedro M.; Farokhzad, Omid Cameron; Karnik, Rohit; Langer, Robert S. (Springer Nature, 2012)
      Using nanoparticles for therapy and imaging holds tremendous promise for the treatment of major diseases such as cancer. However, their translation into the clinic has been slow because it remains difficult to produce ...
    • A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells 

      Stary, G; Olive, A; Radovic-Moreno, A. F.; Gondek, D.; Alvarez, David; Basto, P. A.; Perro, M.; Vrbanac, V. D.; Tager, Andrew Martin; Shi, Jinjun; Yethon, J. A.; Farokhzad, Omid Cameron; Langer, Robert S.; Starnbach, Michael N.; von Andrian, Ulrich H. (American Association for the Advancement of Science (AAAS), 2015)
      Genital Chlamydia trachomatis (Ct) infection induces protective immunity that depends on interferon-γ producing CD4 T-cells. By contrast, mucosal exposure to ultraviolet light (UV)-inactivated Ct (UV-Ct) generated regulatory ...
    • Nanoparticles Containing a Liver X Receptor Agonist Inhibit Inflammation and Atherosclerosis 

      Zhang, Xue-Qing; Even-Or, Orli; Xu, Xiaoyang; van Rosmalen, Mariska; Lim, Lucas; Gadde, Suresh; Farokhzad, Omid Cameron; Fisher, Edward A. (Wiley-Blackwell, 2014)
      Liver X receptor (LXR) signaling pathways regulate lipid metabolism and inflammation, which has generated widespread interest in developing synthetic LXR agonists as potential therapeutics for the management of atherosclerosis. ...
    • Parallel microfluidic synthesis of size-tunable polymeric nanoparticles using 3D flow focusing towards in vivo study 

      Lim, Jong-Min; Bertrand, Nicolas; Valencia, Pedro M.; Rhee, Minsoung; Langer, Robert S.; Jon, Sangyong; Farokhzad, Omid Cameron; Karnik, Rohit (Elsevier BV, 2014)
      Microfluidic synthesis of nanoparticles (NPs) can enhance the controllability and reproducibility in physicochemical properties of NPs compared to bulk synthesis methods. However, applications of microfluidic synthesis are ...
    • Poly(ethylene glycol) with Observable Shedding 

      Gao, Weiwei; Langer, Robert S.; Farokhzad, Omid Cameron (Wiley-Blackwell, 2010)
      A novel FRET-bearing poly(ethylene glycol) (PEG) conjugate fluoresces at 520 nm when it is cleaved off from nanoparticles (NPs). When the NPs were targeted to cancer cell lines, the reducing redox of the endosomal compartment ...
    • Polymeric nanoparticle drug delivery technologies for oral delivery applications 

      Pridgen, Eric M; Alexis, Frank; Farokhzad, Omid Cameron (Informa Healthcare, 2015)
      Introduction: Many therapeutics are limited to parenteral administration. Oral administration is a desirable alternative because of the convenience and increased compliance by patients, especially for chronic diseases ...
    • A Solvent-Free Thermosponge Nanoparticle Platform for Efficient Delivery of Labile Proteins 

      Choi, Won Il; Kamaly, Nazila; Riol-Blanco, Lorena; Lee, In-Hyun; Wu, Jun; Swami, Archana; Vilos, Cristian; Yameen, Basit; Yu, Mikyung; Shi, Jinjun; Tabas, Ira; von Andrian, Ulrich H.; Jon, Sangyong; Farokhzad, Omid C. (American Chemical Society, 2014)
      Protein therapeutics have gained attention recently for treatment of a myriad of human diseases due to their high potency and unique mechanisms of action. We present the development of a novel polymeric thermosponge ...
    • Spontaneous Formation of Heterogeneous Patches on Polymer-Lipid Core-Shell Particle Surfaces during Self-Assembly 

      Salvador-Morales, Carolina; Valencia, Pedro M.; Gao, Weiwei; Karnik, Rohit; Farokhzad, Omid Cameron (Wiley-Blackwell, 2012)
      Spontaneous formation of heterogeneous patches on the surface of lipid-based nanoparticles (NPs) and microparticles (MPs) due to the segregation of two different functional groups. Patch formation is observed when tracing ...
    • Superparamagnetic Iron Oxide Nanoparticle-Aptamer Bioconjugates for Combined Prostate Cancer Imaging and Therapy 

      Wang, Andrew Z.; Bagalkot, Vaishali; Vasilliou, Christophoros C.; Gu, Frank; Alexis, Frank; Zhang, Liangfang; Shaikh, Mariam; Yuet, Kai; Cima, Michael J.; Langer, Robert S.; Kantoff, Philip Wayne; Bander, Neil H.; Jon, Sangyong; Farokhzad, Omid Cameron (Wiley-Blackwell, 2008)
    • Surface Charge-Switching Polymeric Nanoparticles for Bacterial Cell Wall-Targeted Delivery of Antibiotics 

      Radovic-Moreno, Aleksandar F.; Lu, Timothy K.; Puscasu, Vlad A.; Yoon, Christopher J.; Langer, Robert S.; Farokhzad, Omid Cameron (American Chemical Society (ACS), 2012)
      Bacteria have shown a remarkable ability to overcome drug therapy if there is a failure to achieve sustained bactericidal concentration or if there is a reduction in activity in situ. The latter can be caused by localized ...
    • Synergistic cytotoxicity of irinotecan and cisplatin in dual-drug targeted polymeric nanoparticles 

      Valencia, Pedro M; Pridgen, Eric M; Perea, Brian; Gadde, Suresh; Sweeney, Christopher; Kantoff, Philip Wayne; Bander, Neil H; Lippard, Stephen J; Langer, Robert S.; Karnik, Rohit; Farokhzad, Omid Cameron (Future Medicine Ltd, 2013)
      Aim: Two unexplored aspects for irinotecan and cisplatin (I&C) combination chemotherapy are (1) actively targeting both drugs to a specific diseased cell type and (2) delivering both drugs on the same vehicle to ensure ...
    • Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform 

      Gianella, Anita; Mieszawska, Aneta J.; Hoeben, Freek J. M.; Janssen, Henk M.; Jarzyna, Peter A.; Cormode, David P.; Costa, Kevin D.; Rao, Satish; Farokhzad, Omid Cameron; Langer, Robert S.; Fayad, Zahi A.; Mulder, Willem J. M. (Royal Society of Chemistry (RSC), 2013)
      We present a multifunctional nanoparticle platform that has targeting moieties shielded by a matrix metalloproteinase-2 (MMP2) cleavable PEG coating. Upon incubation with MMP2 this surface-switchable coating is removed and ...
    • Synthesis of Polymer–Lipid Nanoparticles for Image-Guided Delivery of Dual Modality Therapy 

      Mieszawska, Aneta J.; Kim, YongTae; Gianella, Anita; van Rooy, Inge; Priem, Bram; Labarre, Matthew P.; Ozcan, Canturk; Cormode, David P.; Petrov, Artiom; Langer, Robert S.; Farokhzad, Omid Cameron; Fayad, Zahi A.; Mulder, Willem J. M. (American Chemical Society (ACS), 2013)
      For advanced treatment of diseases such as cancer, multi component, multi functional nanoparticles hold great promise. In the current study we report the synthesis of a complex nanoparticle (NP) system with dual drug loading ...
    • Synthesis of Size-Tunable Polymeric Nanoparticles Enabled by 3D Hydrodynamic Flow Focusing in Single-Layer Microchannels 

      Rhee, Minsoung; Valencia, Pedro M.; Rodriguez, Maria I.; Langer, Robert S.; Farokhzad, Omid Cameron; Karnik, Rohit (Wiley-Blackwell, 2011)
      A versatile microfluidic platform to synthesize NPs by nanoprecipitation using 3D hydrodynamic flow focusing isolates the precipitating precursors from channel walls, eliminating fouling of the channels. It is shown that ...
    • Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice 

      Fredman, G.; Kamaly, N; Spolitu, S.; Milton, J.; Ghorpade, D.; Chiasson, R.; Kuriakose, G.; Perretti, M.; Farokhzad, Omid Cameron; Tabas, I. (American Association for the Advancement of Science (AAAS), 2015)
      Chronic, nonresolving inflammation is a critical factor in the clinical progression of advanced atherosclerotic lesions. In the normal inflammatory response, resolution is mediated by several agonists, among which is the ...
    • Targeted polymeric therapeutic nanoparticles: design, development and clinical translation 

      Kamaly, Nazila; Xiao, Zeyu; Valencia, Pedro M.; Radovic-Moreno, Aleksandar F.; Farokhzad, Omid Cameron (Royal Society of Chemistry (RSC), 2012)
      Polymeric materials have been used in a range of pharmaceutical and biotechnology products for more than 40 years. These materials have evolved from their earlier use as biodegradable products such as resorbable sutures, ...
    • Transepithelial Transport of Fc-Targeted Nanoparticles by the Neonatal Fc Receptor for Oral Delivery 

      Pridgen, E. M.; Alexis, F.; Kuo, T; Levy-Nissenbaum, E.; Karnik, R.; Blumberg, Richard Steven; Langer, Robert S.; Farokhzad, Omid Cameron (American Association for the Advancement of Science (AAAS), 2013)
      Nanoparticles are poised to have a tremendous impact on the treatment of many diseases, but their broad application is limited because currently they can only be administered by parenteral methods. Oral administration of ...
    • Tumor associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug 

      Miller, Miles A.; Zheng, Yao-Rong; Gadde, Suresh; Pfirschke, Christina; Zope, Harshal; Engblom, Camilla; Kohler, Rainer H.; Iwamoto, Yoshiko; Yang, Katherine S.; Askevold, Bjorn; Kolishetti, Nagesh; Pittet, Mikael; Lippard, Stephen J.; Farokhzad, Omid C.; Weissleder, Ralph (2015)
      Therapeutic nanoparticles (TNPs) aim to deliver drugs more safely and effectively to cancers, yet clinical results have been unpredictable owing to limited in vivo understanding. Here we use single-cell imaging of intratumoral ...
    • Ultra-High Throughput Synthesis of Nanoparticles with Homogeneous Size Distribution Using a Coaxial Turbulent Jet Mixer 

      Lim, Jong-Min; Swami, Archana; Gilson, Laura M.; Chopra, Sunandini; Choi, Sungyoung; Wu, Jun; Langer, Robert; Karnik, Rohit; Farokhzad, Omid C. (American Chemical Society, 2014)
      High-throughput production of nanoparticles (NPs) with controlled quality is critical for their clinical translation into effective nanomedicines for diagnostics and therapeutics. Here we report a simple and versatile ...