Now showing items 21-36 of 36

    • LOng-term follow-up after liVE kidney donation (LOVE) study: a longitudinal comparison study protocol 

      Janki, Shiromani; Klop, Karel W. J.; Kimenai, Hendrikus J. A. N.; van de Wetering, Jacqueline; Weimar, Willem; Massey, Emma K.; Dehghan, Abbas; Rizopoulos, Dimitris; Völzke, Henry; Hofman, Albert; Ijzermans, Jan N. M. (BioMed Central, 2016)
      Background: The benefits of live donor kidney transplantation must be balanced against the potential harm to the donor. Well-designed prospective studies are needed to study the long-term consequences of kidney donation. ...
    • Meta-analysis of rare and common exome chip variants identifies S1PR4 and other loci influencing blood cell traits 

      Pankratz, Nathan; Schick, Ursula M; Zhou, Yi; Zhou, Wei; Ahluwalia, Tarunveer Singh; Allende, Maria Laura; Auer, Paul L; Bork-Jensen, Jette; Brody, Jennifer A; Chen, Ming-Huei; Clavo, Vinna; Eicher, John D; Grarup, Niels; Hagedorn, Elliott J; Hu, Bella; Hunker, Kristina; Johnson, Andrew D; Leusink, Maarten; Lu, Yingchang; Lyytikäinen, Leo-Pekka; Manichaikul, Ani; Marioni, Riccardo E; Nalls, Mike A; Pazoki, Raha; Smith, Albert Vernon; van Rooij, Frank J A; Yang, Min-Lee; Zhang, Xiaoling; Zhang, Yan; Asselbergs, Folkert W; Boerwinkle, Eric; Borecki, Ingrid B; Bottinger, Erwin P; Cushman, Mary; de Bakker, Paul I W; Deary, Ian J; Dong, Liguang; Feitosa, Mary F; Floyd, James S; Franceschini, Nora; Franco, Oscar H; Garcia, Melissa E; Grove, Megan L; Gudnason, Vilmundur; Hansen, Torben; Harris, Tamara B; Hofman, Albert; Jackson, Rebecca D; Jia, Jia; Kähönen, Mika; Launer, Lenore J; Lehtimäki, Terho; Liewald, David C; Linneberg, Allan; Liu, Yongmei; Loos, Ruth J F; Nguyen, Vy M; Numans, Mattijs E; Pedersen, Oluf; Psaty, Bruce M; Raitakari, Olli T; Rich, Stephen S; Rivadeneira, Fernando; Di Sant, Amanda M Rosa; Rotter, Jerome I; Starr, John M; Taylor, Kent D; Thuesen, Betina Heinsbæk; Tracy, Russell P; Uitterlinden, Andre G; Wang, Jiansong; Wang, Judy; Dehghan, Abbas; Huo, Yong; Cupples, L Adrienne; Wilson, James G; Proia, Richard L; Zon, Leonard I; O’Donnell, Christopher J; Reiner, Alex P; Ganesh, Santhi K (2016)
      Hematologic measures such as hematocrit and white blood cell (WBC) count are heritable and clinically relevant. Erythrocyte and WBC phenotypes were analyzed with Illumina HumanExome BeadChip genotypes in 52,531 individuals ...
    • Metabolically Healthy Obesity and the Risk of Cardiovascular Disease in the Elderly Population 

      Dhana, Klodian; Koolhaas, Chantal M.; van Rossum, Elisabeth F. C.; Ikram, M. Arfan; Hofman, Albert; Kavousi, Maryam; Franco, Oscar H. (Public Library of Science, 2016)
      Background: Whether being metabolically healthy obese (MHO)—defined by the presence of obesity in the absence of metabolic syndrome—is associated with subsequent cardiovascular disease (CVD) remains unclear and may depend ...
    • Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis 

      Castaño-Betancourt, Martha C.; Evans, Dan S.; Ramos, Yolande F. M.; Boer, Cindy G.; Metrustry, Sarah; Liu, Youfang; den Hollander, Wouter; van Rooij, Jeroen; Kraus, Virginia B.; Yau, Michelle S.; Mitchell, Braxton D.; Muir, Kenneth; Hofman, Albert; Doherty, Michael; Doherty, Sally; Zhang, Weiya; Kraaij, Robert; Rivadeneira, Fernando; Barrett-Connor, Elizabeth; Maciewicz, Rose A.; Arden, Nigel; Nelissen, Rob G. H. H.; Kloppenburg, Margreet; Jordan, Joanne M.; Nevitt, Michael C.; Slagboom, Eline P.; Hart, Deborah J.; Lafeber, Floris; Styrkarsdottir, Unnur; Zeggini, Eleftheria; Evangelou, Evangelos; Spector, Tim D.; Uitterlinden, Andre G.; Lane, Nancy E.; Meulenbelt, Ingrid; Valdes, Ana M.; van Meurs, Joyce B. J. (Public Library of Science, 2016)
      Osteoarthritis is one of the most frequent and disabling diseases of the elderly. Only few genetic variants have been identified for osteoarthritis, which is partly due to large phenotype heterogeneity. To reduce heterogeneity, ...
    • Obesity and Life Expectancy with and without Diabetes in Adults Aged 55 Years and Older in the Netherlands: A Prospective Cohort Study 

      Dhana, Klodian; Nano, Jana; Ligthart, Symen; Peeters, Anna; Hofman, Albert; Nusselder, Wilma; Dehghan, Abbas; Franco, Oscar H. (Public Library of Science, 2016)
      Background: Overweight and obesity are associated with increased risk of type 2 diabetes. Limited evidence exists regarding the effect of excess weight on years lived with and without diabetes. We aimed to determine the ...
    • Orthostatic hypotension and novel blood pressure-associated gene variants: Genetics of Postural Hemodynamics (GPH) Consortium 

      Fedorowski, Artur; Franceschini, Nora; Brody, Jennifer Karen; Liu, Chunyu; Verwoert, Germaine C.; Boerwinkle, Eric; Couper, David; Rice, Kenneth M.; Rotter, Jerome I.; Mattace-Raso, Francesco; Uitterlinden, Andre; Hofman, Albert; Almgren, Peter; Sjögren, Marketa; Hedblad, Bo; Larson, Martin G.; Newton-Cheh, Christopher Holmes; Wang, Thomas Jue-Fuu; Rose, Kathryn L.; Psaty, Bruce M.; Levy, Daniel; Witteman, Jacqueline; Melander, Olle (Oxford University Press, 2012)
      Aims: Orthostatic hypotension (OH), an independent predictor of mortality and cardiovascular events, strongly correlates with hypertension. Recent genome-wide studies have identified new loci influencing blood pressure ...
    • Orthostatic Hypotension and the Long-Term Risk of Dementia: A Population-Based Study 

      Wolters, Frank J.; Mattace-Raso, Francesco U. S.; Koudstaal, Peter J.; Hofman, Albert; Ikram, M. Arfan (Public Library of Science, 2016)
      Background: Orthostatic hypotension (OH) is a common cause of transient cerebral hypoperfusion in the population. Cerebral hypoperfusion is widely implicated in cognitive impairment, but whether OH contributes to cognitive ...
    • Personalized Prediction of Lifetime Benefits with Statin Therapy for Asymptomatic Individuals: A Modeling Study 

      Ferket, Bart S.; van Kempen, Bob J. H.; Heeringa, Jan; Spronk, Sandra; Fleischmann, Kirsten E.; Nijhuis, Rogier L. G.; Hofman, Albert; Steyerberg, Ewout W.; Hunink, Maria G M (Public Library of Science, 2012)
      Background: Physicians need to inform asymptomatic individuals about personalized outcomes of statin therapy for primary prevention of cardiovascular disease (CVD). However, current prediction models focus on short-term ...
    • Reproductive aging-associated common genetic variants and the risk of breast cancer 

      He, Chunyan; Chasman, Daniel Ian; Dreyfus, Jill; Hwang, Shih-Jen; Ruiter, Rikje; Sanna, Sanna; Buring, Julie Elizabeth; Fernández-Rhodes, Lindsay; Franceschini, Nora; Hankinson, Susan Elizabeth; Hofman, Albert; Lunetta, Kathryn L.; Palmieri, Giuseppe; Porcu, Eleonora; Rivadeneira, Fernando; Rose, Lynda M.; Splansky, Greta L.; Stolk, Lisette; Uitterlinden, André G.; Chanock, Stephen J.; Crisponi, Laura; Demerath, Ellen W.; Murabito, Joanne M.; Ridker, Paul M.; Stricker, Bruno H.; Hunter, David J. (BioMed Central, 2011)
      Introduction: A younger age at menarche and an older age at menopause are well established risk factors for breast cancer. Recent genome-wide association studies have identified several novel genetic loci associated with ...
    • Serum Magnesium and the Risk of Death From Coronary Heart Disease and Sudden Cardiac Death 

      Kieboom, Brenda C. T.; Niemeijer, Maartje N.; Leening, Maarten J. G.; van den Berg, Marten E.; Franco, Oscar H.; Deckers, Jaap W.; Hofman, Albert; Zietse, Robert; Stricker, Bruno H.; Hoorn, Ewout J. (John Wiley and Sons Inc., 2016)
      Background: Low serum magnesium has been implicated in cardiovascular mortality, but results are conflicting and the pathway is unclear. We studied the association of serum magnesium with coronary heart disease (CHD) ...
    • Sex differences in lifetime risk and first manifestation of cardiovascular disease: prospective population based cohort study 

      Leening, Maarten J G; Ferket, Bart S; Steyerberg, Ewout W; Kavousi, Maryam; Deckers, Jaap W; Nieboer, Daan; Heeringa, Jan; Portegies, Marileen L P; Hofman, Albert; Ikram, M Arfan; Hunink, M G Myriam; Franco, Oscar H; Stricker, Bruno H; Witteman, Jacqueline C M; Roos-Hesselink, Jolien W (BMJ Publishing Group Ltd., 2014)
      Objective: To evaluate differences in first manifestations of cardiovascular disease between men and women in a competing risks framework. Design: Prospective population based cohort study. Setting: People living in the ...
    • Stratifying Type 2 Diabetes Cases by BMI Identifies Genetic Risk Variants in LAMA1 and Enrichment for Risk Variants in Lean Compared to Obese Cases 

      Perry, John R. B.; Voight, Benjamin F.; Yengo, Loïc; Amin, Najaf; Dupuis, Josée; Ganser, Martha; Grallert, Harald; Navarro, Pau; Li, Man; Steinthorsdottir, Valgerdur; Almgren, Peter; Arking, Dan E.; Aulchenko, Yurii; Balkau, Beverley; Benediktsson, Rafn; Bergman, Richard N.; Boerwinkle, Eric; Bonnycastle, Lori; Burtt, Noël P.; Campbell, Harry; Charpentier, Guillaume; Collins, Francis S.; Gieger, Christian; Green, Todd; Hadjadj, Samy; Hattersley, Andrew T.; Herder, Christian; Kottgen, Anna; Labrune, Yann; Langenberg, Claudia; Mohlke, Karen L.; Morris, Andrew P.; Oostra, Ben; Pankow, James; Petersen, Ann-Kristin; Pramstaller, Peter P.; Prokopenko, Inga; Rathmann, Wolfgang; Rayner, William; Roden, Michael; Rudan, Igor; Rybin, Denis; Sigurdsson, Gunnar; Sladek, Rob; Thorleifsson, Gudmar; Thorsteinsdottir, Unnur; Tuomilehto, Jaakko; Uitterlinden, Andre G.; Vivequin, Sidonie; Weedon, Michael N.; Wright, Alan F.; Illig, Thomas; Kao, Linda; Wilson, James F.; Stefansson, Kari; van Duijn, Cornelia; Altschuler, David; Morris, Andrew D.; Boehnke, Michael; McCarthy, Mark I.; Froguel, Philippe; Palmer, Colin N. A.; Wareham, Nicholas J.; Groop, Leif; Frayling, Timothy M.; Cauchi, Stéphane; Qi, Lu; Scott, Robert A.; Hofman, Albert; Johnson, Andrew D.; Kraft, Peter; Manning, Alisa K.; Scott, Laura J.; Hu, Frank B.; Meigs, James Benjamin (Public Library of Science, 2012)
      Common diseases such as type 2 diabetes are phenotypically heterogeneous. Obesity is a major risk factor for type 2 diabetes, but patients vary appreciably in body mass index. We hypothesized that the genetic predisposition ...
    • Thyroid function and risk of type 2 diabetes: a population-based prospective cohort study 

      Chaker, Layal; Ligthart, Symen; Korevaar, Tim I. M.; Hofman, Albert; Franco, Oscar H.; Peeters, Robin P.; Dehghan, Abbas (BioMed Central, 2016)
      Background: The association of thyroid function with risk of type 2 diabetes remains elusive. We aimed to investigate the association of thyroid function with incident diabetes and progression from prediabetes to diabetes ...
    • Total Zinc Intake May Modify the Glucose-Raising Effect of a Zinc Transporter (SLC30A8) Variant 

      Kanoni, Stavroula; Nettleton, Jennifer A.; Hivert, Marie-France; Ye, Zheng; van Rooij, Frank J.A.; Shungin, Dmitry; Sonestedt, Emily; Ngwa, Julius S.; Wojczynski, Mary K.; Lemaitre, Rozenn N.; Gustafsson, Stefan; Tanaka, Toshiko; Hindy, George; Saylor, Georgia; Renstrom, Frida; Bennett, Amanda J.; van Duijn, Cornelia M.; Hoogeveen, Ron C.; Houston, Denise K.; Jacques, Paul F.; Johansson, Ingegerd; Lind, Lars; Liu, Yongmei; McKeown, Nicola; Ordovas, Jose; Pankow, James S.; Sijbrands, Eric J.G.; Syvänen, Ann-Christine; Uitterlinden, André G.; Yannakoulia, Mary; Zillikens, M. Carola; Wareham, Nick J.; Prokopenko, Inga; Bandinelli, Stefania; Forouhi, Nita G.; Cupples, L. Adrienne; Loos, Ruth J.; Hallmans, Goran; Dupuis, Josée; Langenberg, Claudia; Ferrucci, Luigi; Kritchevsky, Stephen B.; McCarthy, Mark I.; Ingelsson, Erik; Borecki, Ingrid B.; Witteman, Jacqueline C.M.; Orho-Melander, Marju; Siscovick, David S.; Franks, Paul W.; Dedoussis, George V.; Anderson, Jennifer S.; Florez, Jose Carlos; Fox, Caroline; Hofman, Albert; Hu, Frank B.; Meigs, James Benjamin (American Diabetes Association, 2011)
      Objective: Many genetic variants have been associated with glucose homeostasis and type 2 diabetes in genome-wide association studies. Zinc is an essential micronutrient that is important for β-cell function and glucose ...
    • Trajectories of body mass index before the diagnosis of cardiovascular disease: a latent class trajectory analysis 

      Dhana, Klodian; van Rosmalen, Joost; Vistisen, Dorte; Ikram, M. Arfan; Hofman, Albert; Franco, Oscar H.; Kavousi, Maryam (Springer Netherlands, 2016)
      Patients with cardiovascular disease (CVD) are a heterogeneous group regarding their body mass index (BMI) levels at the time of diagnosis. To address the heterogeneity of CVD, we examined the trajectories of change in ...
    • Validation of a model to investigate the effects of modifying cardiovascular disease (CVD) risk factors on the burden of CVD: the rotterdam ischemic heart disease and stroke computer simulation (RISC) model 

      van Kempen, Bob JH; Ferket, Bart S; Hofman, Albert; Steyerberg, Ewout W; Colkesen, Ersen B; Boekholdt, S Matthijs; Wareham, Nicholas J; Khaw, Kay-Tee; Hunink, MG Myriam (BioMed Central, 2012)
      Background: We developed a Monte Carlo Markov model designed to investigate the effects of modifying cardiovascular disease (CVD) risk factors on the burden of CVD. Internal, predictive, and external validity of the model ...